Zeus_Hunt Posted May 23, 2007 Share Posted May 23, 2007 Quitting marijuana can be extremely difficult. But now better therapies against this addiction in humans could be based on a recently discovered chemical that decreases the desire for marijuana and impedes its brain effects. Rats that received the chemical extracted from larkspur, a plant in the buttercup family, lose their desire for a synthetic molecule of tetrahydrocannabinol (THC), the active chemical found in cannabis. The chemical also stopped a reward response in the rats' brains for the synthetic THC. The team lead by Steven Goldberg at the National Institute on Drug Abuse in Maryland, US, put rats in a cage with a lever the animals could press to get shot with a dose of the synthetic THC. During the three weeks administration, the rats got addicted to the synthetic THC and frequently self-administered the drug while animals that got saline solution did not press the lever too much. When the team injected the rats with methyllycaconitine (MLA), a chemical extracted from the seeds of larkspur (Delphinium brownii), the effects on the rats' behavior were powerful. Just one shot of MLA made the rats administer themselves synthetic THC 70% less than before. MLA also did not seem to affect the rats' movement and coordination or to induce other side effects. The researchers also made microdialysis to fluid samples from the brain's reward-signalling nucleus accumbens.When synthetic THC was administered, dopamine ("pleasure hormone") levels normally boomed in the nucleus accumbens, but MLA impeded the dopamine boost in accumbens."The increases in dopamine are virtually non-existent because of MLA. MLA did not lower dopamine levels below normal amounts. This is important because it suggests that a similar therapy for humans would not interfere with normal reward signalling in the brain. The drug Rimonobant, which makes monkeys less likely to self-administer THC, has been linked to depression in humans." said Goldberg. MLA could attach to certain cell receptors in the brain named alpha-7 nicotinic receptors, but its precise effects are still not known. "There is a genuine need for medications to help cannabis addicts overcome their drug problem. About 10% of the people who experiment with it go on to heavy use and have trouble voluntarily giving it up. I think there is a proportion of the population who need ways to make them stop." said Goldberg. View: Original Article Link to comment Share on other sites More sharing options...
nsane Posted May 24, 2007 Share Posted May 24, 2007 i think the rats weren't addicted to THC, i think they were bored as fuck after sitting in a cage for 3 weeks straight and wanted to party :sui:that 'MLA' only made them more acceptable to brainwashing... Link to comment Share on other sites More sharing options...
toyo Posted May 24, 2007 Share Posted May 24, 2007 wanna quit? do it my way: quit ur smoking friends... :sui:guaranteed way...:eek: Link to comment Share on other sites More sharing options...
Bolt_Gundam510 Posted May 24, 2007 Share Posted May 24, 2007 why stop smokeing pot it does make you smarter in a way by relaxing the nerves and the brain. how much is pot over in India or amsterdam or england any ways? Link to comment Share on other sites More sharing options...
Zeus_Hunt Posted May 25, 2007 Author Share Posted May 25, 2007 I am weed fan.. ;) Its quite cheap in India.6$ is more than enough for a month (1 joint a day) Link to comment Share on other sites More sharing options...
dMog Posted May 26, 2007 Share Posted May 26, 2007 pot...the biggest cash crop in British Columbia Canada....a few years back some plant geneticist did some work and got hybrid pot plants...the result the highest concentrations of thc...now they grow tons of it in the mountains...just like the moonshiners did in Tennessee way back when ;) just one ore reason why Canada rocks.... Link to comment Share on other sites More sharing options...
nsane Posted May 26, 2007 Share Posted May 26, 2007 the US govt. created it's own genetically altered strain way back in the '70s too. it's just that only 1 male plant was every stolen from one of their Mississippi farms and taken back to Switzerland, or something, where it was used to pollinate a female hash plant ;)you may have heard of it as "G13", or G followed by the 13th letter of the alphabet (M) for Government Marijuana :Donly smoked it once myself, got it from an MP i know at the local naval station...https://www.seedboutique.com/store/index.ph...facturers_id=34 - strains made from that 1 stolen plant... Link to comment Share on other sites More sharing options...
lynnig Posted May 26, 2007 Share Posted May 26, 2007 Love the cronic man :D £120-140 per oz in the UK generally. It should be legal and cheaper BTW! ;) Link to comment Share on other sites More sharing options...
nsane Posted May 26, 2007 Share Posted May 26, 2007 jesus man, i can get an oz for $50 (£25) here! ;) Link to comment Share on other sites More sharing options...
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