Treating sleep apnea may reduce dementia risk

[aum]

Illustration of obstruction of ventilation. Credit: Habib M’henni / public domain

 

A new study finds older adults who received positive airway pressure therapy prescribed for obstructive sleep apnea may be less likely to develop Alzheimer's disease and other kinds of dementia.

 

Researchers from Michigan Medicine's Sleep Disorders Centers analyzed Medicare claims of more than 50,000 Medicare beneficiaries ages 65 and older who had been diagnosed with OSA. In this nationally representative study, they examined if those people who used positive airway pressure therapy were less likely to receive a new diagnosis of dementia or mild cognitive impairment over the next 3 years, compared to people who did not use positive airway pressure.

 

"We found a significant association between positive airway pressure use and lower risk of Alzheimer's and other types of dementia over three years, suggesting that positive airway pressure may be protective against dementia risk in people with OSA," says lead author Galit Levi Dunietz, Ph.D., M.P.H., an assistant professor of neurology and a sleep epidemiologist.

 

The findings stress the impact of sleep on cognitive function. "If a causal pathway exists between OSA treatment and dementia risk, as our findings suggest, diagnosis and effective treatment of OSA could play a key role in the cognitive health of older adults," says study principal investigator Tiffany J. Braley, M.D., M.S., an associate professor of neurology.

 

Obstructive sleep apnea is a condition in which the upper airway collapses repeatedly throughout the night, preventing normal breathing during sleep. OSA is associated with a variety of other neurological and cardiovascular conditions, and many older adults are at high risk for OSA.

 

And dementia is also prevalent, with approximately 5.8 million Americans currently living with it, Braley says.

 

Source

[Karlston]

It's starting to look like a link between sleep issues and dementia.

 

A system in the brain called the Glymphatic system was only discovered in 2013. It's role is similar to the body's lymphatic system, except it's to flush out waste from the Central Nervous System (brain & spine), including waste whose build-up has been implicated in various neurodegenerative diseases.

 

This system runs 24/7, but most importantly increases by a factor of 20 during non-REM sleep. Insufficent non-REM sleep could lead to an ongoing build-up of waste and possibly these horrid diseases.