humble3d Posted November 28, 2014 Share Posted November 28, 2014 'Off switch' for pain discovered: Activating the adenosine A3 receptor subtype is key to powerful pain reliefDate:November 26, 2014Source:Saint Louis University Medical CenterSummary:A way to block a pain pathway in animal models of chronic neuropathic pain has been discovered by researchers, suggesting a promising new approach to pain relief... Read some more.... Pain is an enormous problem. As an unmet medical need, pain causes suffering and comes with a multi-billion dollar societal cost. Current treatments are problematic because they cause intolerable side effects, diminish quality of life and do not sufficiently quell pain. In research published in the medical journal Brain, Saint Louis University researcher Daniela Salvemini, Ph.D. and colleagues within SLU, the National Institutes of Health (NIH) and other academic institutions have discovered a way to block a pain pathway in animal models of chronic neuropathic pain including pain caused by chemotherapeutic agents and bone cancer pain suggesting a promising new approach to pain relief. The scientific efforts led by Salvemini, who is professor of pharmacological and physiological sciences at SLU, demonstrated that turning on a receptor in the brain and spinal cord counteracts chronic nerve pain in male and female rodents. Activating the A3 receptor -- either by its native chemical stimulator, the small molecule adenosine, or by powerful synthetic small molecule drugs invented at the NIH -- prevents or reverses pain that develops slowly from nerve damage without causing analgesic tolerance or intrinsic reward (unlike opioids).An Unmet Medical Need Pain is an enormous problem. As an unmet medical need, pain causes suffering and comes with a multi-billion dollar societal cost. Current treatments are problematic because they cause intolerable side effects, diminish quality of life and do not sufficiently quell pain.The most successful pharmacological approaches for the treatment of chronic pain rely on certain "pathways": circuits involving opioid, adrenergic, and calcium channels.For the past decade, scientists have tried to take advantage of these known pathways -- the series of interactions between molecular-level components that lead to pain. While adenosine had shown potential for pain-killing in humans, researchers had not yet successfully leveraged this particular pain pathway because the targeted receptors engaged many side effects.A Key to Pain Relief In this research, Salvemini and colleagues have demonstrated that activation of the A3 adenosine receptor subtype is key in mediating the pain relieving effects of adenosine."It has long been appreciated that harnessing the potent pain-killing effects of adenosine could provide a breakthrough step towards an effective treatment for chronic pain," Salvemini said. "Our findings suggest that this goal may be achieved by focusing future work on the A3AR pathway, in particular, as its activation provides robust pain reduction across several types of pain."Researchers are excited to note that A3AR agonists are already in advanced clinical trials as anti-inflammatory and anticancer agents and show good safety profiles. "These studies suggest that A3AR activation by highly selective small molecular weight A3AR agonists such as MRS5698 activates a pain-reducing pathway supporting the idea that we could develop A3AR agonists as possible new therapeutics to treat chronic pain," Salvemini said.Story Source:The above story is based on materials provided by Saint Louis University Medical Center. Note: Materials may be edited for content and length.Journal Reference: J. W. Little, A. Ford, A. M. Symons-Liguori, Z. Chen, K. Janes, T. Doyle, J. Xie, L. Luongo, D. K. Tosh, S. Maione, K. Bannister, A. H. Dickenson, T. W. Vanderah, F. Porreca, K. A. Jacobson, D. Salvemini. Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states. Brain, 2014; DOI: 10.1093/brain/awu330Cite This Page:MLAAPAChicagoSaint Louis University Medical Center. "'Off switch' for pain discovered: Activating the adenosine A3 receptor subtype is key to powerful pain relief." ScienceDaily. ScienceDaily, 26 November 2014. <www.sciencedaily.com/releases/2014/11/141126132639.htm>. http://www.sciencedaily.com/releases/2014/11/141126132639.htmhttp://www.sciencedaily.com/releases/2014/11/141126132639.htm Link to comment Share on other sites More sharing options...
RobrPatty Posted November 29, 2014 Share Posted November 29, 2014 This is amazing. Will it work on the wife because she is a real pain in the arse! :s :s Link to comment Share on other sites More sharing options...
gws Posted November 29, 2014 Share Posted November 29, 2014 This is amazing. Will it work on the wife because she is a real pain in the arse! :s :s Hahahahaha Link to comment Share on other sites More sharing options...
rasbridge Posted November 30, 2014 Share Posted November 30, 2014 I hope they can fast-track it because I am recovering from knee surgery now. I have been told that I will need knee replacement when I can no longer tolerate the pain. Hopefully, by then, they can turn off my knee pain (cartilage is gone). If so, that means that I will never need knee replacement surgery. That would truly be wonderful... Link to comment Share on other sites More sharing options...
VileTouch Posted November 30, 2014 Share Posted November 30, 2014 that's OLD news, buddy. Tramadol have been in the market for YEARS and it does exactly as described.in some places it's even sold over the counter :) Link to comment Share on other sites More sharing options...
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