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Foot cream kills HIV by tricking cells to commit suicide


DKT27
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Though the research has yet to be performed on people, Ciclopirox completely eradicates HIV from cell cultures -- and the virus doesn't bounce back when the drug is stopped.

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Ciclopirox is currently approved by the FDA as a topical antifungal cream.

A common drug that dermatologists prescribe to treat nail fungus appears to come with a not-so-tiny side effect: eradicating HIV.

In a study performed at Rutgers New Jersey Medical School, not only does the drug Ciclopirox completely eradicate infectious HIV from cell cultures, but unlike today's most cutting-edge antiviral treatments, the virus doesn't bounce back when the drug is withheld. This means it may not require a lifetime of use to keep HIV at bay.

The same group of researchers had previously shown that Ciclopirox -- approved by the FDA and Europe's EMA as safe for human use to treat foot fungus -- inhibits the expression of HIV genes in culture. Now they have found that it also blocks the essential function of the mitochondria, which results in the reactivation of the cell's suicide pathway, all while sparing the healthy cells.

The researchers said that one aspect of HIV that makes it particularly persistent, even in the face of strong antiviral treatments, is its ability to disable a cell's altruistic suicide pathway -- which is typically activated when a cell is damaged or infected. In other words, infected cells that would normally commit suicide to spare healthy cells no longer pull any altruistic kamikaze missions. Ciclopirox tricks these cells back into their old ways with a double negative, disabling the disabling of the suicide pathway.

It's obviously still going to take clinical trials on humans to study the safety and efficacy of Ciclopirox as a potential topical HIV treatment, but the fact that it's already deemed safe for one type of human use could make the regulatory process faster than usual.

In fact, the researchers note that another FDA-approved drug now thought to help subdue HIV, called Deferiprone, skipped studies in animals and went straight from tests in culture to a phase I human trial in South Africa, possibly paving the way for other FDA-approved drugs to move faster through the study phases. (Unlike Ciclopirox, which is approved for topical treatment, Deferiprone is FDA- and EMA-approved for systemic use, meaning it effects more than just one part of the body.)

The new findings on Ciclopirox appear in the current issue of the journal PLOS ONE.

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Since HIV is internal, it would make sense to ingest this....but this warning comes from a Ciclopirox page:

http://www.healthwarehouse.com/ciclopirox-8-topical-solution-6-6ml-bottle.html

This medication may be harmful if swallowed. If overdose or swallowing is suspected, contact a poison control center or emergency room immediately. US residents should call the US National Poison Hotline at 1-800-222-1222. Canada residents should call a provincial poison control center.

So after I get my foot all creamed up where do I stick it to stop the HIV?

Well...good question. This might seem like a strange suggestion as to how we can get this inside us but...inside the anus MIGHT be a very impractical way of delivery...not the most pleasant however. The anatomy of inside the anus is vulnerable to foreign contaminates easily due to the amount of blood vessels inside which will absorb much of the medicine, but safety is once again the question here. Is that method safe? Preperation H works fine inside but Im not sure about this. If I had HIV, I would test it.

Edited by Ambrocious
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This, is just a new finding, which is not so easy to implement on humans. I'm reading on the comments on the original article that such anti-fungals are never made for inside the body, and if one cures HIV with it, one might face other complications if this cream is taken or injected. We, can, however try to understand how this drug is doing this and hence, improve the drug further so that it isn't harmful or, make another drug based on this idea.

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This, is just a new finding, which is not so easy to implement on humans. I'm reading on the comments on the original article that such anti-fungals are never made for inside the body, and if one cures HIV with it, one might face other complications if this cream is taken or injected. We, can, however try to understand how this drug is doing this and hence, improve the drug further so that it isn't harmful or, make another drug based on this idea.

now this is what critical thinking is...

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