Hydroxychloroquine should not be hastily dismissed as Covid-19 treatment, researchers say

[dufus]

 

Researchers behind a global study into whether hydroxychloroquine can prevent coronavirus have warned against dismissing the dug prematurely, saying it could still save lives.

 

The Oxford University-led study, known as Copcov, is aiming to enrol 40,000 healthcare workers from across the world to determine whether the drug is effective at fighting Covid-19.

 

Hydroxychloroquine has been regularly discredited as an acceptable treatment for the virus, with multiple scientific studies suggesting the anti-malaria drug can actually do more harm than good.

 

Donald Trump, who has touted the medicine’s potential benefits throughout the pandemic, told a news briefing on Monday that it has become “politically toxic” only because “I supported it”.

 

He told reporters: “If I had said 'do not use hydroxychloroquine under any circumstances,' they (health officials) would have come out and said it's a great thing.”

 

The US president took a two-week course of the medication in May, even as the country’s top infectious disease expert, Dr Anthony Fauci, dismissed the drug.

 

Meanwhile, the researchers behind Copcov have stressed that, while the drug has been ruled out as a method to treat infections, it may still be able to prevent them.

 

One of the trial’s lead investigators Dr Will Schilling said: “We really don’t know if hydroxychloroquine works or not in prevention or very early treatment. That question remains unanswered.

 

“The benefits found in small post-exposure treatment trials, although modest, could be very valuable if they were confirmed.”

 

Professor Nick Day, director of the Mahidol Oxford Tropical Medicine Research Unit which is also guiding the study, said the Copcov trial will be able to find a definitive answer to the drug’s effectiveness.

 

He said: “By the time patients are admitted to hospital virus multiplication is well past its peak and inflammation in the lungs and other complications may prove lethal.

 

“At this stage the steroid dexamethasone, which reduces inflammation, saves lives but the antivirals hydroxychloroquine and chloroquine do not.

 

“However, that does not rule out that they could be effective much earlier in the illness. Prevention is much easier than cure.

 

"The Copcov study will find out if these drugs can prevent Covid-19 or not.”

source

 

interesting info on hydroxychloroquine , chloroquine ... google has a patent .....

 

Treatment of radiation disorders

Abstract
The present invention provides methods and compositions for the treatment of DNA damage related disorders. One embodiment is a method for the inhibition of side effects associated with chemotherapeutic and radiotherapeutic agents using chloroquine compounds. Another embodiment is a method for treatment and/or prevention of lethal or sub-lethal radiation toxicities associated with terrorist acts or war.

 

Chloroquine improves survival and hematopoietic recovery after lethal low-dose-rate radiation.

New Study Shows Promise for Repurposing Anti-Malarial Drug for Cancer Treatment

[dMog]

not working and proved a million times over for covid...end of story

 

make that a Billion times over😀

[dufus]

might be worth keeping just in case one of the old nuclear power stations  has an accidental leak ...  google,s got the terrorist angle covered  so that,s ok .... one other option would be  to donate the us uk stockpiles to japan .....Fukushima’s Contaminated Wastewater Could Be Too Risky to Dump in the Ocean 

 

UK spent £20m buying up stocks of HIV and malaria drugs

US stockpile stuck with 63 million doses of hydroxychloroquine

Palmer buys 32,900,000 doses of Hydroxychloroquine for Australians

[mp68terr]

Quote

... interesting info on hydroxychloroquine , chloroquine ... google has a patent ...

The patent is from early 2000, chloroquine was discovered in 1934 by Hans Andersag. It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication. https://en.wikipedia.org/wiki/Chloroquine

Google found out that the chloroquine-like molecules can be used outside of the treatment of malaria. How can one say that google 'invented' it? Would the patent work if the drugs are used outside of the treatment of DNA damage associated with chemotherapeutic and radiotherapeutic agents, e.g. for the covid-19?

[dufus]

Abstract

The present invention provides methods and compositions for the treatment of DNA damage related disorders. One embodiment is a method for the inhibition of side effects associated with chemotherapeutic and radiotherapeutic agents using chloroquine compounds. Another embodiment is a method for treatment and/or prevention of lethal or sub-lethal radiation toxicities associated with terrorist acts or war.

 

that ,s what i find interesting ...... especially the final sentence ....

[mp68terr]

Interesting indeed, also using already existing compounds more widely than first thought. Don't know if there are effective ways to treat/prevent lethal or sub-lethal radiation toxicities associated with terrorist acts or war, as noted.

Wondering if someone here knows well about how patents work. (And how they are attributed considering that there is neither invention nor discovery of a new compound.) The above abstract does not seem to cover the case of covid-19.

[dufus]

Abstract

The present invention provides methods and compositions for the treatment of DNA damage related disorders. One embodiment is a method for the inhibition of side effects associated with chemotherapeutic and radiotherapeutic agents using chloroquine compounds. Another embodiment is a method for treatment and/or prevention of lethal or sub-lethal radiation toxicities associated with terrorist acts or war.

 

no it does not ....