World’s first baby born with new “3 parent” technique

[Batu69]

John Zhang holds the baby

 

It’s a boy! A five-month-old boy is the first baby to be born using a new technique that incorporates DNA from three people, New Scientist can reveal. “This is great news and a huge deal,” says Dusko Ilic at King’s College London, who wasn’t involved in the work. “It’s revolutionary.”

 

The controversial technique, which allows parents with rare genetic mutations to have healthy babies, has only been legally approved in the UK. But the birth of the child, whose Jordanian parents were treated by a US-based team in Mexico, should fast-forward progress around the world, say embryologists.

 

The boy’s mother carries genes for Leigh syndrome, a fatal disorder that affects the developing nervous system. Genes for the disease reside in DNA in the mitochondria, which provide energy for our cells and carry just 37 genes that are passed down to us from our mothers. This is separate from the majority of our DNA, which is housed in each cell’s nucleus.

 

Around a quarter of her mitochondria have the disease-causing mutation. While she is healthy, Leigh syndrome was responsible for the deaths of her first two children. The couple sought out the help of John Zhang and his team at the New Hope Fertility Center in New York City.

 

Zhang has been working on a way to avoid mitochondrial disease using a so-called “three-parent” technique. In theory, there are a few ways of doing this. The method approved in the UK is called pronuclear transfer and involves fertilising both the mother’s egg and a donor egg with the father’s sperm. Before the fertilised eggs start dividing into early-stage embryos, each nucleus is removed. The nucleus from the donor’s fertilised egg is discarded and replaced by that from the mother’s fertilised egg.

 

But this technique wasn’t appropriate for the couple – as Muslims, they were opposed to the destruction of two embryos. So Zhang took a different approach, called spindle nuclear transfer. He removed the nucleus from one of the mother’s eggs and inserted it into a donor egg that had had its own nucleus removed. The resulting egg – with nuclear DNA from the mother and mitochondrial DNA from a donor – was then fertilised with the father’s sperm.

 

Zhang’s team used this approach to create five embryos, only one of which developed normally. This embryo was implanted in the mother and the child was born nine months later. “It’s exciting news,” says Bert Smeets at Maastricht University in the Netherlands. The team will describe the findings at the American Society for Reproductive Medicine’s Scientific Congress in Salt Lake City in October.

 

Neither method has been approved in the US, so Zhang went to Mexico instead, where he says “there are no rules”. He is adamant that he made the right choice. “To save lives is the ethical thing to do,” he says.

 

The team seems to have taken an ethical approach with their technique, says Sian Harding, who reviewed the ethics of the UK procedure. The team avoided destroying embryos, and used a male embryo, so that the resulting child wouldn’t pass on any inherited mitochondrial DNA. “It’s as good as or better than what we’ll do in the UK,” says Harding.

 

 

A remaining concern is safety. Last time embryologists tried to create a baby using DNA from three people was in the 1990s, when they injected mitochondrial DNA from a donor into another woman’s egg, along with sperm from her partner. Some of the babies went on to develop genetic disorders, and the technique was banned. The problem may have arisen from the babies having mitochondria from two sources.

 

When Zhang and his colleagues tested the boy’s mitochondria, they found that less than 1 per cent carry the mutation. Hopefully, this is too low to cause any problems; generally it is thought to take around 18 per cent of mitochondria to be affected before problems start. “It’s very good,” says Ilic.

 

Smeets agrees, but cautions that the team should monitor the child to make sure the levels stay low. There’s a chance that faulty mitochondria could be better at replicating, and gradually increase in number, he says. “We need to wait for more births, and to carefully judge them,” says Smeets.

Two women, one man and a baby

A Jordanian couple has been trying to start a family for almost 20 years. Ten years after they married, she became pregnant, but it ended in the first of four miscarriages.

 

In 2005, the couple gave birth to a baby girl. It was then that they discovered the probable cause of their fertility problems: a genetic mutation in the mother’s mitochondria. Their daughter was born with Leigh syndrome, which affects the brain, muscles and nerves of developing infants. Sadly, she died aged six. The couple’s second child had the same disorder, and lived for 8 months.

 

Using a controversial “three-parent baby” technique (see main story), the boy was born on 6 April 2016. He is showing no signs of disease.

 

Article source

[flash48]

Now a days you hear kids saying, "I have two daddies" or, "I have two mommies".  It won't be long before we start hearing  "I have two mommies and one daddy".

 

Also, a while back I read a story where a man and a women got married, and after they had two kids, went for a sex change procedure.  Now those two kids are saying, "She is my father and, "he is my mother".

 

The advancement of technology is a two edged sword.  Yes it can do amazing good things but, somehow the results just do not sound right.

 

[CODYQX4]

.

[calguyhunk]

I'm not entirely sure Cody and Flash read the article and saw the new reports on TV before commenting. This is not a 'two mommies and 1 daddy' sort of debauched modern family situation. The headline is a bit clickbaity and doesn't exactly represent the real scenario. There's only one pair of mom and dad here.

 

This is basically standard IVF procedure that have helped millions of childless couples around the become parents over the past several decades. The only difference in this case was that the scientists changed the mitochondrial DNA (without touching the majority nuclear DNA) of the mother with that of a donor to take away the 37 defective genes that would have otherwise been passed from mother to child, resulting in a kid born with a deadly neurological disease.

 

I don't know whether all medical ethics were followed here, but from whatever I've read, I think this would be great if it actually helps doctors filter out mutated and/or defective genes to help the birth of healthy babies rather than ones with terrible conditions, which would make their and their caregivers' lives miserable in more ways than one. YMMV.

[Batu69]

1 hour ago, calguyhunk said:

I'm not entirely sure Cody and Flash read the article and saw the new reports on TV before commenting.

 

They read but just read title not article contents .

May be they read after see your post and try to understand what article contents is

[nIGHT]

I am lucky I was able to read calguyhunks and batu69's  posts before thinking to comment here.  Lol!

But there is something wrong here, the doctor intended to use something called the "three-parent" technique only to deviate from that technique to something called  "spindle nuclear egg" method that is acceptable for the muslim couple.

 

On 9/28/2016 at 1:28 PM, Batu69 said:

Zhang has been working on a way to avoid mitochondrial disease using a so-called “three-parent” technique. In theory, there are a few ways of doing this. The method approved in the UK is called pronuclear transfer and involves fertilising both the mother’s egg and a donor egg with the father’s sperm. Before the fertilised eggs start dividing into early-stage embryos, each nucleus is removed. The nucleus from the donor’s fertilised egg is discarded and replaced by that from the mother’s fertilised egg.

 

But this technique wasn’t appropriate for the couple – as Muslims, they were opposed to the destruction of two embryos. So Zhang took a different approach, called "spindle nuclear transfer". He removed the nucleus from one of the mother’s eggs and inserted it into a donor egg that had had its own nucleus removed. The resulting egg – with nuclear DNA from the mother and mitochondrial DNA from a donor – was then fertilised with the father’s sperm.

This baby is born with the "spindle nuclear transfer" technique, hence, the title for this topic is wrong.

[Batu69]

5 hours ago, nIGHT said:

This baby is born with the "spindle nuclear transfer" technique, hence, the title for this topic is wrong.

 

Maybe original author not put "spindle nuclear transfer" as article title to make their readers easy to understand.

Choose simple article title is important to pull readers to read the article.

[nIGHT]

@Batu69 I know that you didn't wrote  It.was addressed to the original author. You might be right about the title for the purpose of being a click-bait.