Combining blood pressure medication and ibuprofen may cause harms

Researchers from the University of Waterloo have discovered that people taking both a diuretic and a renin-angiotensin system (RSA) inhibitor for high blood pressure should be careful when also taking ibuprofen, a common over-the-counter painkiller.

Diuretics and RSA inhibitors are often prescribed together to manage hypertension and are known by various brand names.

Ibuprofen, found in popular brands, is readily available at most pharmacies and stores.

In their study, the research team used computer simulations to model how these three drugs interact and affect the kidneys. They found that for some individuals, this combination can lead to acute kidney injury, which may sometimes be permanent.

The researchers emphasize that not everyone taking these drugs will encounter problems. However, the study highlights that the risk exists and people should be cautious.

This finding is especially relevant for those managing high blood pressure, who might not think twice about using ibuprofen for pain relief.

Diuretics help the body expel excess water, and dehydration is a significant risk factor for acute kidney injury. The combination of a diuretic, RSA inhibitor, and ibuprofen creates a “triple whammy” effect on the kidneys.

For those on high blood pressure medication in need of a painkiller, the researchers recommend considering acetaminophen as a safer alternative.

This important study was led by Anita Layton and her team.

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