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<rss version="2.0"><channel><title>News: General News</title><link>https://nsaneforums.com/news/general-news/page/318/?d=2</link><description>News: General News</description><language>en</language><item><title>Physicists have created &#x201C;everlasting bubbles&#x201D;</title><link>https://nsaneforums.com/news/general-news/physicists-have-created-%E2%80%9Ceverlasting-bubbles%E2%80%9D-r3978/</link><description><![CDATA[<header>
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		One gas bubble lasted for a whopping 465 days, a world record for this type of object.
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		<img alt="bubbleGIF.gif" class="ipsImage" data-ratio="53.57" height="300" width="560" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/bubbleGIF.gif">
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					The shell of a water/glycerol gas marble (bubble) remains liquid and spherical even after 101 days, and it reacts as a liquid film when punctured. These human-made bubbles could be used to create stable foams.
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					A. Roux et al., 2022
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			Blowing soap bubbles never fails to delight one's inner child, perhaps because they are intrinsically ephemeral, bursting after just a few minutes. Now, French physicists have succeeded in creating "everlasting bubbles" out of plastic particles, glycerol, and water, according to <a href="https://journals.aps.org/prfluids/abstract/10.1103/PhysRevFluids.7.L011601" rel="external nofollow">a new paper</a> published in the journal Physical Review Fluids. The longest bubble they built survived for a whopping 465 days.
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			Bubbles have long fascinated physicists. For instance, French physicists in 2016 <a href="https://physics.aps.org/articles/v9/21" rel="external nofollow">worked out</a> a theoretical model for the exact mechanism for how soap bubbles form when jets of air hit a soapy film. The researchers found that bubbles only formed above a certain speed, which in turn depends on the width of the jet of air.
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			In 2018, <a href="https://arstechnica.com/science/2018/09/theres-now-an-even-more-precise-recipe-for-blowing-the-perfect-bubble/" rel="external nofollow">we reported</a> on how mathematicians at New York University's Applied Math Lab had fine-tuned the method for blowing the perfect bubble based on a series of experiments with thin, soapy films. The mathematicians concluded that it's best to use a circular wand with a 1.5-inch (3.8 cm) perimeter and gently blow at a consistent 2.7 inches per second (6.9 cm/s). Blow at higher speeds and the bubble will burst. If you use a smaller or larger wand, the same thing will happen.
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			And in 2020, <a href="https://arstechnica.com/science/2020/02/physicists-determine-the-optimal-soap-recipe-for-blowing-gigantic-bubbles/" rel="external nofollow">physicists determined</a> that a key ingredient for creating gigantic bubbles is mixing in polymers of varying strand lengths. That produces a soap film able to <a href="https://journals.aps.org/prfluids/abstract/10.1103/PhysRevFluids.5.013304" rel="external nofollow">stretch sufficiently thin</a> to make a giant bubble without breaking. The polymer strands become entangled, like a hairball, forming longer strands that don't want to break apart. In the right combination, a polymer allows a soap film to reach a 'sweet spot' that's viscous but also stretchy—just not so stretchy that it rips apart. Varying the length of the polymer strands resulted in a sturdier soap film.
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			Scientists are also interested in extending the longevity of bubbles. Bubbles naturally take on the form of a sphere: a volume of air encased in a very thin liquid skin that isolates each bubble in a foam from its neighbors. Bubbles owe their geometry to the phenomenon of surface tension, a force that arises from molecular attraction. The greater the surface area, the more energy that is required to maintain a given shape, which is why the bubbles seek to assume the shape with the least surface area: a sphere.
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			<img alt="bubble1-640x290.jpg" class="ipsImage" data-ratio="45.31" height="290" width="640" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/bubble1-640x290.jpg">
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					Comparison of the lifetime of three types of bubbles. (a) Soap bubble, 1 minute; (b) water gas marble, 6-9 minutes; (c) water/glycerol gas marble, 101+ days.
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					A. Roux et al,. 2022
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			However, most bubbles burst within minutes in a standard atmosphere. Over time, the pull of gravity gradually drains the liquid downward, and at the same time, the liquid component slowly evaporates. As the amount of liquid decreases, the "walls" of the bubbles become very thin, and small bubbles in a foam combine into larger ones. The combination of these two effects is called "coarsening." Adding some kind of surfactant keeps surface tension from collapsing bubbles by strengthening the thin liquid film walls that separate them. But eventually the inevitable always occurs.
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			In 2017, French physicists <a href="https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.118.228001" rel="external nofollow">found that</a> a spherical shell made of plastic microspheres can store pressurized gas in a tiny volume. The physicists dubbed the objects "gas marbles." The objects are related to so-called liquid marbles—droplets of liquid coated with microscopic, liquid-repelling beads, which can roll around on a solid surface without breaking apart. While the mechanical properties of gas marbles have been the subject of several studies, no one had conducted experiments to explore the marbles' longevity.
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			So Aymeric Roux of the University of Lille and several colleagues decided to fill that gap. They experimented with three different kinds of bubbles: standard soap bubbles, gas marbles made using water, and gas marbles made with water and glycerol. To make their gas marbles, Roux et al. spread plastic particles on the surface of a water bath, which jammed together to form a granular raft. Then the researchers injected a bit of air with a syringe just below the raft to form bubbles and used a spoon to push the bubbles over the raft until the entire surface of each bubble was coated with plastic particles.
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			<img alt="bubble2-640x213.jpg" class="ipsImage" data-ratio="33.28" height="213" width="640" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/bubble2-640x213.jpg">
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					Lifetime of liquid films attached to a metallic frame. (L) horizontal frames; (R) pyramidal frame.
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				<div>
					A. Roux et al., 2022
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			The standard soap bubbles burst within a minute or so, as expected. But Roux et al. found that the plastic particle coating significantly neutralized the drainage process for the water-based gas marbles, which collapsed between six and 60 minutes. To extend the lifetime even further, the researchers needed to also neutralize the evaporation.
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			So they added glycerol to the water. According to the authors, glycerol has a high concentration of hydroxyl groups, which in turn have a strong affinity with water molecules, creating strong hydrogen bonds. So glycerol is better able to absorb water from air, thereby compensating for evaporation. The water/glycerol gas marbles lasted significantly longer: from five weeks to 465 days, enabling the researchers to determine the best ratio of water-to-glycerol—the perfect recipe for long-lived gas marbles.
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			The researchers' work even extends beyond bubbles. They were also able to create robust composite liquid films and shape them into different objects by dipping a metallic frame below a liquid surface covered with a layer of jammed plastic particles. The frame captured particle-coated films as it was slowly lifted back up to the surface. Most notably, Roux et al. were able to build a 3D pyramid shape out of a water/glycerol liquid film. The pyramid has lasted for over 378 days (and counting).
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			DOI: Physical Review Fluids, 2022. <a href="http://dx.doi.org/10.1103/PhysRevFluids.7.L011601" rel="external nofollow">10.1103/PhysRevFluids.7.L011601</a>  (<a href="http://arstechnica.com/science/news/2010/03/dois-and-their-discontents-1.ars" rel="external nofollow">About DOIs</a>).
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			Listing image by A. Roux et al, 2022
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<p>
	<a href="https://arstechnica.com/science/2022/01/physicists-have-created-everlasting-bubbles/" rel="external nofollow">Physicists have created “everlasting bubbles”</a>
</p>
]]></description><guid isPermaLink="false">3978</guid><pubDate>Fri, 21 Jan 2022 02:28:35 +0000</pubDate></item><item><title>The genetic engineering behind pig-to-human transplants</title><link>https://nsaneforums.com/news/general-news/the-genetic-engineering-behind-pig-to-human-transplants-r3977/</link><description><![CDATA[<div data-page="1">
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				A paper on a transplant to a brain-dead recipient provides details on the donor.
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					Last week, when we reported on the first <a href="https://arstechnica.com/science/2022/01/pig-heart-transplanted-to-human-for-the-first-time/" rel="external nofollow">pig-to-human heart transplant</a>, we complained that the commercial company behind the operation wasn't more forthcoming about the genetic engineering that converted the pig into a viable donor.
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					We now know much more about porcine genetic engineering thanks to a new paper covering a different, more cautious test procedure. The work described in the paper is a transplant of pig kidneys into a brain-dead recipient and is meant to pave the way for trials in viable humans. The publication that describes the work contains extensive details on the genetic engineering used to ensure that the pig tissue would survive in a human host.
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					A test case
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					According to The New York Times, the recipient was <a href="https://www.nytimes.com/2022/01/20/health/transplants-pig-human-kidney.html" rel="external nofollow">rendered brain-dead by a motorcycle accident</a>. He had signed up as an organ donor and was kept alive while his organs were screened; his next of kin gave informed consent to his body's use in the experimental procedure.
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					By the time the transplant took place, however, the recipient had been kept alive for five days and required blood transfusions and anticoagulants. The transplant team described his body as being in a state of severe "physiologic derangement." Ultimately, three days after the transplant, a severe hemorrhage effectively drained the body of blood and brought an end to the experiment.
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					The transplant was meant to parallel, to the greatest extent possible, a standard human kidney transplant. The intent was to prepare for a small clinical trial at the same facility.
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					The donor pig came from a facility where all animals are regularly screened for viral infections. Prior to transplantation, the recipient's serum was tested to ensure it did not contain antibodies that recognized cells from the donor. To further limit the chance of rejection, the recipient was treated with antibodies that targeted and depleted his T cells. Standard immunosuppressive drugs were then given for the remaining three days.
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					However, those efforts were secondary to work that was done years earlier to engineer the pig's genome so that its cells were less likely to trigger a human immune response.
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					The engineering
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					The pig itself was provided by a company called Revivicor, which also generated the donor for the pig heart transplant. These pigs have had a number of their own genes eliminated and several human genes introduced. The primary focus of these changes is to reduce the likelihood that the human immune system will recognize the pig's tissue as foreign.
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					Three of the pig genes that were deleted encode enzymes that attach carbohydrate molecules to proteins that reside on the surface of cells. These carbohydrate molecules are not typically essential for the function of the proteins they're linked to (more accurately, they're attached to plenty of proteins but are only important for a few). The precise arrangement of the carbohydrate molecules, however, can vary from species to species, so the molecules used by one species might be recognized as foreign by the immune system of another.
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					The deleted pig genes encode enzymes that generate carbohydrate modifications that aren't produced by human cells. Their elimination means the carbohydrates that they normally attach are no longer present and thus can't be recognized as foreign. For similar reasons, genes responsible for blood type were also deleted, allowing the pigs to be universal donors. A gene that encodes the receptor for a growth hormone was also deleted in order to limit the potential for the organ and/or its cells to grow uncontrollably following the transplant.
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					In addition, a number of human genes were added to the pig genome. Two of these genes produce proteins that inhibit something called the complement system. This system consists of a number of proteins that attach to cells that are recognized by antibodies; once there, they form holes in the membranes, killing the cell. The immune system typically uses this process to kill infected cells, but it could also kill foreign cells, such as those in a transplant.
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					Another gene added to the pig genome was the human version of <a href="https://en.wikipedia.org/wiki/CD47" rel="external nofollow">CD47</a>, which helps prevent the immune system from identifying and swallowing abnormal cells. The HO1 gene, which is often activated to limit the inflammatory response, was also added.
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					Two additional genes act as anticoagulants, which should limit the formation of clots in the transplanted organ.
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					The outcome
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					The procedure didn't get off to a great start. The donor kidneys were examined prior to transplantation and appeared to have "reduced structural integrity" compared to the organs they were replacing. There were no reports of this being an issue with the genetically engineered pigs, so the surgical team wasn't entirely sure what caused the problem or whether it altered the kidneys' function. Regardless, the kidneys didn't seem to be ideal candidates for thriving in an environment termed "physiologic derangement."
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					In any case, one of the two kidneys started producing urine almost immediately after the transplant and went on to make over half a liter within the first 24 hours. The other, however, never really started functioning.
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					By the third day, there was clearly increasing damage in the tubules that make up much of the internal structure of the kidney, including many indications of dying cells. However, other signs of the disorders normally associated with this symptom were lacking, so it wasn't clear what was happening.
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					Overall, the researchers interpret this damage as an indication that the complement system, meant to be disabled by the genetic engineering, was likely being activated by an alternative pathway. But they haven't confirmed this is the case or identified the factors that activated the complement system yet. And as noted above, the recipient's system was already going through a lot, which could have produced an abnormal response. Presumably, an uninjured organ recipient would not have as many issues.
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					So it's hard to say where this leaves plans for clinical trials of the procedure. Still, by publishing this paper, the surgeons behind this work have taken a key step toward opening up their methods to input from the wider scientific community. That increases the likelihood that some of the unknowns will have plausible answers soon.
				</p>

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				<p>
					American Journal of Transplantation, 2022. DOI: <a href="http://dx.doi.org/10.1111/ajt.16930" rel="external nofollow">10.1111/ajt.16930</a>  (<a href="http://arstechnica.com/science/news/2010/03/dois-and-their-discontents-1.ars" rel="external nofollow">About DOIs</a>).
				</p>
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<p>
	 
</p>

<p>
	<a href="https://arstechnica.com/science/2022/01/the-genetic-engineering-behind-pig-to-human-transplants/" rel="external nofollow">The genetic engineering behind pig-to-human transplants</a>
</p>
]]></description><guid isPermaLink="false">3977</guid><pubDate>Fri, 21 Jan 2022 02:26:21 +0000</pubDate></item><item><title>Scientists Are Racing to Understand the Fury of Tonga&#x2019;s Volcano</title><link>https://nsaneforums.com/news/general-news/scientists-are-racing-to-understand-the-fury-of-tonga%E2%80%99s-volcano-r3970/</link><description><![CDATA[<div>
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					The Hunga Tonga-Hunga Ha'apai eruption and tsunami are unlike anything volcanologists have seen before.
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								On December 20, Hunga Tonga-Hunga Ha'apai—an underwater volcano in the South Pacific topped with a diminutive and uninhabited island—awoke from a seven-year slumber. The volcano spluttered and crackled, creating a large plume of ash. Ten thousand miles away, in England, Simon Proud, a satellite data researcher at the University of Oxford, began to monitor the twitching volcano using an array of satellites.
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								As 2021 ticked into 2022, what had appeared to be the beginnings of an almighty eruption seemingly calmed down. Then, early in the morning on January 14 local Tongan time, a 12-mile-high plume of ash pierced the sky. The volcano became increasingly turbulent, and hundreds of lightning discharges <a data-event-click='{"element":"ExternalLink","outgoingURL":"https://www.nationalgeographic.com/science/article/the-science-behind-the-tonga-eruption-and-tsunami"}' data-offer-url="https://www.nationalgeographic.com/science/article/the-science-behind-the-tonga-eruption-and-tsunami" href="https://www.nationalgeographic.com/science/article/the-science-behind-the-tonga-eruption-and-tsunami" rel="external nofollow" target="_blank">shot out of the maelstrom</a> every second, bombarding the land and ocean. And one day later, in the <a data-event-click='{"element":"ExternalLink","outgoingURL":"https://www.theguardian.com/world/2022/jan/17/tonga-volcano-a-visual-guide-to-the-eruption-and-its-aftermath"}' data-offer-url="https://www.theguardian.com/world/2022/jan/17/tonga-volcano-a-visual-guide-to-the-eruption-and-its-aftermath" href="https://www.theguardian.com/world/2022/jan/17/tonga-volcano-a-visual-guide-to-the-eruption-and-its-aftermath" rel="external nofollow" target="_blank">late afternoon of January 15</a>, satellites captured a cataclysm in action.
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								Back in England, when Proud woke up that day and checked his computer, he saw a tower of ash unlike anything he, or anyone else, had ever seen. Satellites had captured images of a huge column of ash that billowed out 22 miles above the island into a shadowy, tempestuous canopy 160 miles long. Rising from the canopy’s heart was a thin, transient spike of volcanic debris reaching an altitude of 34 miles—about five times the height of a cruising passenger jet. “What the heck is this?” Proud recalls thinking. “I looked at the data, and I thought, this is so far outside anything I’ve seen before. It’s just unreal.”
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								Jaws dropped across the world. The explosion that produced the ash cloud, one estimated to be equivalent to <a data-event-click='{"element":"ExternalLink","outgoingURL":"https://www.npr.org/2022/01/18/1073800454/nasa-scientists-estimate-tonga-blast-at-10-megatons?t=1642540260451"}' data-offer-url="https://www.npr.org/2022/01/18/1073800454/nasa-scientists-estimate-tonga-blast-at-10-megatons?t=1642540260451" href="https://www.npr.org/2022/01/18/1073800454/nasa-scientists-estimate-tonga-blast-at-10-megatons?t=1642540260451" rel="external nofollow" target="_blank">10 million tons of TNT</a>, unleashed 25,000 times more energy than the lethal <a data-event-click='{"element":"ExternalLink","outgoingURL":"https://graphics.reuters.com/LEBANON-SECURITY/BLAST/yzdpxnmqbpx/"}' data-offer-url="https://graphics.reuters.com/LEBANON-SECURITY/BLAST/yzdpxnmqbpx/" href="https://graphics.reuters.com/LEBANON-SECURITY/BLAST/yzdpxnmqbpx/" rel="external nofollow" target="_blank">blast in the Lebanese capital Beirut in August 2020</a>. The Tonga eruption is easily one of the largest explosions this century. And it didn’t stop there.
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								“Then there was the shockwave,” says Mike Cassidy, a volcanologist at the University of Oxford. It emanated from the volcanic blast at 600 mph and caused pressure spikes on the other side of the planet. “No one’s ever seen that before.” Within 20 minutes of the explosion, four-foot tsunami waves cascaded over Tongatapu, the archipelagic Kingdom of Tonga’s main island. By the time minor tsunami waves hit Japan and the western shorelines of the Americas, ash had already smothered multiple Tongan islands, killing off agriculture, polluting water supplies, disrupting electrical infrastructure, and cutting off roads and runways. The submarine communication cable connecting the archipelago to the rest of the world was damaged, severing the nation’s international phone and internet services. It likely won’t be repaired for several weeks.
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								Volcanologists couldn’t believe what they were witnessing. No matter which metric you picked, this was an astonishing, terrible eruption. And as suddenly as the volcanic violence dwindled, a global detective story began. What series of geologic events created such a devastating eruption? And what research needs to be done to crack the case?
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								The general mechanisms of volcanic eruptions are broadly known. But the catastrophic explosion on January 15 needs a more thorough examination and, ultimately, a novel explanation. When Hunga Tonga-Hunga Ha'apai erupted, <a data-event-click='{"element":"ExternalLink","outgoingURL":"https://unidirectory.auckland.ac.nz/profile/s-cronin"}' data-offer-url="https://unidirectory.auckland.ac.nz/profile/s-cronin" href="https://unidirectory.auckland.ac.nz/profile/s-cronin" rel="external nofollow" target="_blank">Shane Cronin</a>, a volcanologist at the University of Auckland in New Zealand, had the same reaction as everyone else, volcanologist or not: holy shit.
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								“But there was actually a ‘holy shit’ moment on December 30,” he says. On that day, a decently tall plume emerged from the volcano. “That put me on notice because it was very violent.” Then came another skyscraping plume just prior to the main event. Both featured relatively little volcanic material, but did contain a lot of gas. And gloopy magma filled with gas is bad news. Very much like an agitated fizzy drink trapped in a bottle, if you suddenly remove the cap, that gas expands and blasts the drink out of the top with remarkable momentum. In other words, these two volcanic belches indicated that the magma reservoir had a lot of trapped gas, portending the epic blast yet to come. “In 20/20 hindsight, those were a big warning to us,” says Cronin.
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								The two once-conjoined but now segregated islands of Hunga Tonga and Hunga Ha'apai are the small surface expression of a far larger, 12-mile-long cauldron-shaped volcano (known as a caldera) beneath the waves. And it’s long been known that that titan contains a lot of gassy magma. Cronin is the coauthor of a <a data-event-click='{"element":"ExternalLink","outgoingURL":"https://www.researchgate.net/publication/357889614_Post-caldera_volcanism_reveals_shallow_priming_of_an_intra-ocean_arc_andesitic_caldera_Hunga_volcano_Tonga_SW_Pacific"}' data-offer-url="https://www.researchgate.net/publication/357889614_Post-caldera_volcanism_reveals_shallow_priming_of_an_intra-ocean_arc_andesitic_caldera_Hunga_volcano_Tonga_SW_Pacific" href="https://www.researchgate.net/publication/357889614_Post-caldera_volcanism_reveals_shallow_priming_of_an_intra-ocean_arc_andesitic_caldera_Hunga_volcano_Tonga_SW_Pacific" rel="external nofollow" target="_blank">recent study</a> that looked into the caldera’s volcanic past. It found that its magma reservoir takes many centuries to refill, and last weekend’s major paroxysm takes place roughly once a millennium, the result of the violent and sudden emptying of most of that cache of molten rock.
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								Rare though it may have been, this explosion still came from a volcanic bomb, and bombs need triggers—but what kind? Cronin and his colleagues have an idea: Over time, fluids dissolved in the magma, like water, began to bubble out as gases, upping the pressure on the rocky cap above. The volcano inflated, causing cracks to appear in its cap. Eventually, the seawater above infiltrated those fissures and encountered the magma. That’s when all hell broke loose.
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								This water, rapidly heated, was vaporized into a gas. If this happened miles below the sea surface, the intense weight of the ocean would suppress the expansion of the gas into the surrounding magma. But being just a few hundred feet below the waves, the water blasted the magma out of the way like a superpowered pneumatic pump, fragmenting the molten rock into millions of pieces. “And boom,” says Cronin. “Away we go.”
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								That first explosion clears the way for more magma to meet seawater, which creates more explosions that lets even more magma meet seawater, all while the vast reservoir of molten rock dramatically depressurizes and rushes into the sea. “That is going to result in a very violent chain reaction,” says <a data-event-click='{"element":"ExternalLink","outgoingURL":"https://www.smitchellscience.com/"}' data-offer-url="https://www.smitchellscience.com/" href="https://www.smitchellscience.com/" rel="external nofollow" target="_blank">Sam Mitchell</a>, a volcanologist at the University of Bristol. “There is water to spare, heat to spare, and magma to spare.” And in a heartbeat you create a 10-megaton explosion.
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								That’s the hypothesis, anyway. To confirm this requires chemistry. If scientists can collect ash that was produced both prior to and during the paroxysm, the different chemical and textural features of both sets of particles will reveal the explosion’s trigger. If the ash is extremely fine, plentiful, and exhibits tiny fractures, for example, it almost certainly came from magma angrily interacting with seawater.
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								Chemistry will also reveal what turned the magma into a pressurized bomb in the first place. The prevalence of a certain type of microscopic volcanic crystals would reveal the magma sat just below the surface for many years, slowly degassing and pressurizing. But the presence of a specific coating on these crystals would indicate that a recent injection of magma came in from below, adding a critical amount of heat, gas, and pressure to the reservoir. The blast’s ginormous ash plume, too, will provide scientists with vital clues. But it took a few days to properly calculate its dimensions.
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								Plumes happily rise into the troposphere, the lowest layer of the atmosphere and the bit that contains most of the world’s weather. Temperature drops with altitude, so based on how cold the plume is, you can roughly measure how high it goes, says Proud. “In this case, when it’s blasted all the way through into the stratosphere, things get a little bit more challenging,” he adds. The stratosphere warms with altitude, so using temperature in this rarified air produces erroneous plume heights.
							</p>

							<p>
								Instead, Proud and his colleagues used multiple satellites to visually calculate its height. And after marking the plume’s canopy at 22 miles, with a central spike at 34 miles—a spike reaching an even higher atmospheric layer, the <a data-event-click='{"element":"ExternalLink","outgoingURL":"https://climate.nasa.gov/news/2919/earths-atmosphere-a-multi-layered-cake/"}' data-offer-url="https://climate.nasa.gov/news/2919/earths-atmosphere-a-multi-layered-cake/" href="https://climate.nasa.gov/news/2919/earths-atmosphere-a-multi-layered-cake/" rel="external nofollow" target="_blank">mesosphere</a>—Proud only had one way to describe it: “It’s totally nuts,” he says.
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								The staggeringly high-altitude plume gives an indication of how explosive the eruption was, says Cassidy, which in turn will help explain the mechanisms that led to such a major blast. “It must have been a really explosive event,” says Proud. The erupted ash, he adds, must have been going up close to the speed of sound in order to get that high. But working out what caused the blast is just one half of the puzzle. The other is the tsunami’s trigger, and although it is tempting to simply blame the blast, its origin story is not quite as clear cut.
							</p>

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								Submarine volcanoes that quickly build unstable islands above water through eruptions are prone to generating dangerous tsunamis. Prior to this month’s disaster, the most recent lethal volcanic tsunami was the <a data-event-click='{"element":"ExternalLink","outgoingURL":"https://www.bgs.ac.uk/news/child-of-krakatoa-why-the-2018-eruption-caused-a-tsunami/"}' data-offer-url="https://www.bgs.ac.uk/news/child-of-krakatoa-why-the-2018-eruption-caused-a-tsunami/" href="https://www.bgs.ac.uk/news/child-of-krakatoa-why-the-2018-eruption-caused-a-tsunami/" rel="external nofollow" target="_blank">2018 eruption of Indonesia’s Anak Krakatau</a>, which killed hundreds of people. And whether a tsunami is caused by a meteor impact, an earthquake, or a volcano, the number one rule remains unchanged: You need to move a large mass of something into water. But there are various ways a volcano can achieve this: an underwater explosion, the collapse of the volcano’s flank (as <a data-event-click='{"element":"ExternalLink","outgoingURL":"https://www.sciencedirect.com/science/article/abs/pii/S0025322721001481?casa_token=d5jJ1jwaUpYAAAAA:H8WaYbsZFXBXX2D49whpUF63BzvmaWj0NMRs3_vCRMCeiaCTPwODZoi3I4bLMgy1PqLgfK8#f0005"}' data-offer-url="https://www.sciencedirect.com/science/article/abs/pii/S0025322721001481?casa_token=d5jJ1jwaUpYAAAAA:H8WaYbsZFXBXX2D49whpUF63BzvmaWj0NMRs3_vCRMCeiaCTPwODZoi3I4bLMgy1PqLgfK8#f0005" href="https://www.sciencedirect.com/science/article/abs/pii/S0025322721001481?casa_token=d5jJ1jwaUpYAAAAA:H8WaYbsZFXBXX2D49whpUF63BzvmaWj0NMRs3_vCRMCeiaCTPwODZoi3I4bLMgy1PqLgfK8#f0005" rel="external nofollow" target="_blank">happened with Anak Krakatau</a>), the collapse of the entire volcano, or vast amounts of volcanic debris from the eruption plume tumbling into the sea.
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								Shockwaves, too, can generate tsunamis. Not long after the January 15 blast, tsunami waves weren’t just detected around the shorelines of the Pacific, but elsewhere in the world, including the Caribbean Sea. Such waves couldn’t have been caused by the movement of the volcano’s rock, as continental barriers would have blocked them. Instead, it appears that the shockwave—which, at the time of writing, has <a data-event-click='{"element":"ExternalLink","outgoingURL":"https://twitter.com/EIlyinskaya/status/1483891935395950594"}' data-offer-url="https://twitter.com/EIlyinskaya/status/1483891935395950594" href="https://twitter.com/EIlyinskaya/status/1483891935395950594" rel="external nofollow" target="_blank">travelled around the planet three times</a>—didn’t just stay airborne. It interacted with distant seas, causing them to bob up and down, <a data-event-click='{"element":"ExternalLink","outgoingURL":"https://twitter.com/geophysichick/status/1482495062390890496"}' data-offer-url="https://twitter.com/geophysichick/status/1482495062390890496" href="https://twitter.com/geophysichick/status/1482495062390890496" rel="external nofollow" target="_blank">triggering small tsunamis</a> thousands of miles from the explosion’s source.
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								This is a phenomenon known as a <a data-event-click='{"element":"ExternalLink","outgoingURL":"https://oceanservice.noaa.gov/facts/meteotsunami.html"}' data-offer-url="https://oceanservice.noaa.gov/facts/meteotsunami.html" href="https://oceanservice.noaa.gov/facts/meteotsunami.html" rel="external nofollow" target="_blank">meteotsunami</a>. Although previously detected underneath potent storm systems, this may be the <a data-event-click='{"element":"ExternalLink","outgoingURL":"https://twitter.com/DrGregDusek/status/1482430663806660617"}' data-offer-url="https://twitter.com/DrGregDusek/status/1482430663806660617" href="https://twitter.com/DrGregDusek/status/1482430663806660617" rel="external nofollow" target="_blank">first time a volcano has been detected causing one</a> in a different ocean basin altogether. But although it may have played a small role, scientists are not currently eyeing the shockwave, but the redecoration of the volcano itself, as the prime suspect behind the severe Tongan tsunami.
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								But how, precisely, was the tsunami caused? If it was a flank collapse, the rocky debris underwater would fan out in a single direction away from the now-felled sector of the volcano. If the entire volcano collapsed in on itself after its magmatic foundations were rapidly evacuated from its vent, then you might expect a ring of debris radiating out around its perimeter, with perhaps more wreckage in one direction if the collapse was asymmetrical. And an underwater explosion, depending on whether it was directed or more widespread across the volcano, could be represented by either of these two debris patterns.
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								The only way to find out, says Mitchell, is to look. Blasting acoustic waves from boats down to the volcano, perhaps by using <a data-event-click='{"element":"ExternalLink","outgoingURL":"https://www.nytimes.com/2019/12/03/science/axial-volcano-mapping.html?fbclid=IwAR3EfuDOwElO0zqrMAzabfH4KRr4_k-AN8GXZrhjcC-CecNBl92KgCh5GqY"}' data-offer-url="https://www.nytimes.com/2019/12/03/science/axial-volcano-mapping.html?fbclid=IwAR3EfuDOwElO0zqrMAzabfH4KRr4_k-AN8GXZrhjcC-CecNBl92KgCh5GqY" href="https://www.nytimes.com/2019/12/03/science/axial-volcano-mapping.html?fbclid=IwAR3EfuDOwElO0zqrMAzabfH4KRr4_k-AN8GXZrhjcC-CecNBl92KgCh5GqY" rel="external nofollow" target="_blank">small explosives or pneumatic air guns</a>, and subsequently receiving their reflections, can tell scientists about the dimensions and properties of the rocks below. This allows them to make a map of the volcano post-eruption, and comparing it to pre-eruption maps can reveal how the volcano has changed shape or if it’s blown a new hole in its side. Robotic diving vehicles, those controlled remotely by a pilot or <a href="https://www.wired.co.uk/article/nasa-submarines-searching" rel="external nofollow">fully autonomous submersibles</a> requiring no human input, could also be deployed to scour the seafloor.
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								In addition to this submarine sleuthing, the buoys and coastal gauges that measured the tsunami wave heights and arrival times across the Pacific Ocean will be crucial. After this data is collected, it can be plugged into computer models to try and recreate the tsunami. If a simulated tsunami is found to match with the pattern of underwater debris, then researchers can confidently reconstruct the volcanic event that caused the real deal.
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								Preliminary satellite data gives some early hints. “I don’t think a huge caldera drop, maybe, is the answer,” says Cronin. The two islands of Hunga Tonga and Hunga Ha'apai don’t appear to have sunken much post-eruption, suggesting the volcano didn’t fully collapse. There is also plenty of volcanic debris on the seafloor created by similarly explosive but far more ancient events to last weekend’s blast. That implies that, even though there was a massive explosion above water, a significant amount of that blast may have transpired underwater. If so, it could have propelled vast amounts of volcanic debris—comparable to the volume jettisoned skyward—into the sea, triggering a tsunami. But until this fieldwork is conducted, a conclusion is beyond reach. For the time being, “there’s a lot of scratching of heads,” says Cronin.
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								From the blast to the tsunami, the science behind this singular eruption is rife with unanswered questions. In fact, right now, there are only two certainties: The first is that this has been a tragedy for Tonga, but future lives will be saved if this eruption’s deadly features can be decoded; the second is that Tonga, a small nation now scarred by this eruption, cannot achieve this scientific goal alone.
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								The kingdom’s own volcanologists, including those at the Tongan Geological Services, have been monitoring nearby volcanoes, which they know better than anyone. But the agency has very little funding, says Mitchell. “They can’t go out and do huge bathymetric surveys and deploy ocean-bottom seismometers,” he adds. Scientists from around the world, then, must come together to crack the case of Hunga Tonga-Hunga Ha'apai. “If we help, it needs to be in tandem with them, not in lieu of them.” And what helps protect Tonga also protects millions of others around the world. Earth is dotted with similarly gigantic volcanos that will, one day, unleash similarly devastating eruptions. And, when that happens, knowledge gained from the Tonga eruption could prove crucial in giving early warning when another planet-shaking blast is about to occur.
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<p>
	<a href="https://www.wired.com/story/tonga-volcano-eruption-science/" rel="external nofollow">Scientists Are Racing to Understand the Fury of Tonga’s Volcano</a>
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	(May require free registration to view)
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]]></description><guid isPermaLink="false">3970</guid><pubDate>Thu, 20 Jan 2022 19:10:37 +0000</pubDate></item><item><title>Nocebo responses explain up to 76% of COVID vaccine side effects</title><link>https://nsaneforums.com/news/general-news/nocebo-responses-explain-up-to-76-of-covid-vaccine-side-effects-r3965/</link><description><![CDATA[<header>
	<h2 itemprop="description">
		Some vaccine side effects are very real, but many may be anxiety and misattribution.
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			Even before their rollout, a distinct feature of safe and effective COVID-19 vaccines has been their "<a href="https://www.nature.com/articles/s41541-019-0132-6" rel="external nofollow">reactogenicity</a>"—that is, their tendency to cause mild symptoms that signal immune responses firing up after a shot, particularly the second one. As vaccine supplies were unleashed in the US last year, families, friends, and coworkers swapped stories of their harrowing post-jab days, often recalling fevers, chills, fatigue, and general crumminess.
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			Although those experiences are unquestionably real, their connection to the vaccines may not be. As more and more results from randomized-controlled vaccine trials hit science journals, researchers kept noting that, while trial participants often reported mild symptoms after shots, so too did the participants who received placebos—and not at trivial levels.
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			Many people are familiar with "placebo effects," which happen when an inert intervention leads people to report health benefits that couldn't possibly have been caused by the faux treatment. Placebo effects are well-documented and real—in that people can indeed experience a certain extent of psychosomatic benefits. A placebo will not treat serious medical conditions, such as cancer, but it could, for example, lead people to feel they have more energy or less general discomfort.
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			But placebos also have a dark side. The harmless interventions can just as easily lead people to report harmful side effects, particularly when people are expecting such side effects. Researchers have coined these phantom adverse reactions "nocebo responses." Nocebo responses are thought to stem from expectations of side effects, anxiety-induced effects, and the mistaken attribution of common, nonspecific ailments, like headaches, to the placebo.
		</p>

		<h2>
			COVID vaccine nocebos
		</h2>

		<p>
			Nocebo responses were startlingly common in trials of COVID-19 vaccines, and a new study quantified just how big a role they played. <a href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2788172" rel="external nofollow">The meta-analysis, led by Harvard researchers and published Tuesday in JAMA Network Open</a>, looked at side-effect data from 12 high-quality randomized clinical trials testing various COVID-19 vaccines against inert placebo control groups. The analysis concluded that nocebo responses accounted for 76 percent of systemic adverse reactions—like headache, fever, and chills—after the first vaccine dose and 52 percent of systemic reactions after the second vaccine dose.
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			The rates of side effects in the placebo groups were "substantial," the researchers, led by Harvard research scientist Julia Haas, concluded. While common, nonspecific symptoms, like fatigue and headache, are among the most common side effects linked to the vaccines, the study found them "to be particularly associated with nocebo."
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			Of course, the point of this analysis isn't just to make you question your sanity (although, seriously, your mind might be messing with you). The main point is that these nocebo responses are likely making safe, life-saving vaccines seem significantly less pleasant than they actually are—and apprehension about such unpleasant side effects is a known reason why some people choose not to get vaccinated.
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			"Informing the public about the potential for nocebo responses may help reduce worries about COVID-19 vaccination, which might decrease vaccination hesitancy," Haas and her colleagues wrote. In addition, some clinical evidence suggests that making people aware of nocebo responses can also lower their expectation for side effects and thereby actually lead to fewer perceived side effects.
		</p>

		<h2>
			Real effects
		</h2>

		<p>
			Of course, not all side effects are nocebo responses; some are clearly real, particularly local reactions and side effects after the second dose of a COVID-19 vaccine.
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			In the meta-analysis, Haas and her colleagues found that about 35 percent of placebo recipients reported at least one systemic side effect after their first faux dose. Meanwhile, 46 percent of vaccine recipients reported at least one systemic side effect after getting their first real dose. When the researchers looked at the severity levels of all of those systemic side effects, they found similar proportions of severity grades between the placebo and vaccine groups. In other words, the vaccine group wasn't collectively reporting more severe side effects than the placebo group. But there was a clear difference in the local side effects. Only 16 percent of placebo recipients reported local side effects, like pain or swelling at the injection site, while 67 percent of the vaccine group reported such effects.
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			After the second dose, there were even more differences. About 32 percent of the placebo group reported at least one systemic effect, while 61 percent of the vaccine group reported systemic effects. And in this case, the vaccine group tended to report more moderate to severe systemic effects than the placebo group. As in the first shot, the vaccine group had more local side effects, with about 73 percent reporting local effects while only about 12 percent of people in the placebo group reported them.
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			Overall, the nocebo responses clearly seem to be skewing our experience with COVID-19 vaccines, which are being used the world over. As such, the researchers argue that highlighting the potential for nocebo responses could reduce side effects and help improve vaccine uptake.
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</p>

<p>
	<a href="https://arstechnica.com/science/2022/01/up-to-76-of-covid-vaccine-side-effects-are-just-in-peoples-heads-study-finds/" rel="external nofollow">Nocebo responses explain up to 76% of COVID vaccine side effects</a>
</p>
]]></description><guid isPermaLink="false">3965</guid><pubDate>Thu, 20 Jan 2022 03:15:29 +0000</pubDate></item><item><title>GM announces plans to make mobile power generators using hydrogen fuel cells</title><link>https://nsaneforums.com/news/general-news/gm-announces-plans-to-make-mobile-power-generators-using-hydrogen-fuel-cells-r3956/</link><description><![CDATA[<div>
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			<strong>The aim is to replace polluting gas- and diesel-powered generators with zero-emission hydrogen-powered ones</strong>
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<div>
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				<picture data-cdata='{"image_id":70408884,"ratio":"*"}' data-cid="site/picture_element-1642622404_3089_36516"> <source sizes="(min-width: 1221px) 846px, (min-width: 880px) calc(100vw - 334px), 100vw" srcset="https://cdn.vox-cdn.com/thumbor/UeV87TXlQeLL_cOjORZ-NDTX7ow=/0x0:3096x1556/320x213/filters:focal(1301x531:1795x1025):format(webp)/cdn.vox-cdn.com/uploads/chorus_image/image/70408884/EMPOWER_rapid_charger.0.jpg 320w, https://cdn.vox-cdn.com/thumbor/OIpQmAaYa7jzNjVxJ8pcR5uGAhw=/0x0:3096x1556/620x413/filters:focal(1301x531:1795x1025):format(webp)/cdn.vox-cdn.com/uploads/chorus_image/image/70408884/EMPOWER_rapid_charger.0.jpg 620w, https://cdn.vox-cdn.com/thumbor/b9BnMS9vhlGQFC--gUZox1SNaq0=/0x0:3096x1556/920x613/filters:focal(1301x531:1795x1025):format(webp)/cdn.vox-cdn.com/uploads/chorus_image/image/70408884/EMPOWER_rapid_charger.0.jpg 920w, https://cdn.vox-cdn.com/thumbor/yIzbonTL3VIAGqVhqODQ094lBzg=/0x0:3096x1556/1220x813/filters:focal(1301x531:1795x1025):format(webp)/cdn.vox-cdn.com/uploads/chorus_image/image/70408884/EMPOWER_rapid_charger.0.jpg 1220w, https://cdn.vox-cdn.com/thumbor/o6HbfRlct50eeAZWyDLKJbx4E3w=/0x0:3096x1556/1520x1013/filters:focal(1301x531:1795x1025):format(webp)/cdn.vox-cdn.com/uploads/chorus_image/image/70408884/EMPOWER_rapid_charger.0.jpg 1520w, https://cdn.vox-cdn.com/thumbor/pPs6OlIBh3KS0s_3ey3fM95GmOs=/0x0:3096x1556/1820x1213/filters:focal(1301x531:1795x1025):format(webp)/cdn.vox-cdn.com/uploads/chorus_image/image/70408884/EMPOWER_rapid_charger.0.jpg 1820w, https://cdn.vox-cdn.com/thumbor/iKzYIDLtrCRBNqYlli1QY-PuC2M=/0x0:3096x1556/2120x1413/filters:focal(1301x531:1795x1025):format(webp)/cdn.vox-cdn.com/uploads/chorus_image/image/70408884/EMPOWER_rapid_charger.0.jpg 2120w, https://cdn.vox-cdn.com/thumbor/_kATiOJ_POlU4BRqAottjQ9h_FQ=/0x0:3096x1556/2420x1613/filters:focal(1301x531:1795x1025):format(webp)/cdn.vox-cdn.com/uploads/chorus_image/image/70408884/EMPOWER_rapid_charger.0.jpg 2420w" type="image/webp">  </source></picture><img alt="EMPOWER_rapid_charger.0.jpg" class="ipsImage" data-ratio="75.10" height="479" width="720" src="https://cdn.vox-cdn.com/thumbor/b9BnMS9vhlGQFC--gUZox1SNaq0=/0x0:3096x1556/920x613/filters:focal(1301x531:1795x1025):format(webp)/cdn.vox-cdn.com/uploads/chorus_image/image/70408884/EMPOWER_rapid_charger.0.jpg">
			</p>

			<figcaption>
				GM’s EMPOWER rapid charger can help retail fuel stations add more affordable DC fast-charging capabilities
			</figcaption>
			GM
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		<div>
			<p id="KSLxE1">
				General Motors announced plans to manufacture mobile power generators using its Hydrotec-branded hydrogen fuel cells.
			</p>

			<p>
				 
			</p>

			<p id="bQc1QD">
				The aim is to replace polluting gas- and diesel-powered generators with zero-emission hydrogen-powered ones. Hydrogen is the most abundant element in the universe, so its appeal to an industry that’s trying to pivot away from dirty internal combustion engines is obvious. <a href="https://www.theverge.com/2017/4/13/15257576/hydrogen-fuel-cell-honda-clarity-self-driving-ny-auto-show-2017" rel="external nofollow">Some automakers are developing hydrogen-powered cars</a> as a possible alternative to EVs that use lithium-ion batteries. With today’s announcement, GM is staking out a position that looks beyond the car and power generation.
			</p>

			<figure>
				<p>
					<picture data-cdata='{"asset_id":23179673,"ratio":"*"}' data-cid="site/picture_element-1642622405_6219_36517"> <source sizes="(min-width: 1221px) 846px, (min-width: 880px) calc(100vw - 334px), 100vw" srcset="https://cdn.vox-cdn.com/thumbor/RDFdv5NB9_yXbscSjL_MWdjcBFo=/0x0:2113x1390/320x0/filters:focal(0x0:2113x1390):format(webp):no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23179673/GM_MPG.jpg 320w, https://cdn.vox-cdn.com/thumbor/BoLK-tYC7Nlbq0cMpiY_y-cVq28=/0x0:2113x1390/520x0/filters:focal(0x0:2113x1390):format(webp):no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23179673/GM_MPG.jpg 520w, https://cdn.vox-cdn.com/thumbor/PFsFPvi8YaDPaze4Q58xkT0tGKw=/0x0:2113x1390/720x0/filters:focal(0x0:2113x1390):format(webp):no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23179673/GM_MPG.jpg 720w, https://cdn.vox-cdn.com/thumbor/Doz_GWJUmCVMpPXaJDXrGnt9olY=/0x0:2113x1390/920x0/filters:focal(0x0:2113x1390):format(webp):no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23179673/GM_MPG.jpg 920w, https://cdn.vox-cdn.com/thumbor/iQxwT_dA8kYl7DXsaX6GmLhSbPk=/0x0:2113x1390/1120x0/filters:focal(0x0:2113x1390):format(webp):no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23179673/GM_MPG.jpg 1120w, https://cdn.vox-cdn.com/thumbor/7zLz91FIAhuoLYWNibXrD7Dfuzk=/0x0:2113x1390/1320x0/filters:focal(0x0:2113x1390):format(webp):no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23179673/GM_MPG.jpg 1320w, https://cdn.vox-cdn.com/thumbor/RDhwL6w8wgpGKsOtYD-0qgDyc6Y=/0x0:2113x1390/1520x0/filters:focal(0x0:2113x1390):format(webp):no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23179673/GM_MPG.jpg 1520w, https://cdn.vox-cdn.com/thumbor/JadkOfmDeO3rRsLOe5qznStRxzU=/0x0:2113x1390/1720x0/filters:focal(0x0:2113x1390):format(webp):no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23179673/GM_MPG.jpg 1720w, https://cdn.vox-cdn.com/thumbor/xfwinzCX70l8llFM_FgLyqCQcfQ=/0x0:2113x1390/1920x0/filters:focal(0x0:2113x1390):format(webp):no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23179673/GM_MPG.jpg 1920w" type="image/webp">  </source></picture>
				</p>

				<p>
					<img alt="GM_MPG.jpg" class="ipsImage" data-ratio="75.10" height="473" width="720" src="https://cdn.vox-cdn.com/thumbor/Doz_GWJUmCVMpPXaJDXrGnt9olY=/0x0:2113x1390/920x0/filters:focal(0x0:2113x1390):format(webp):no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23179673/GM_MPG.jpg">
				</p>

				<figcaption>
					GM’s Mobile Power Generator can fast-charge EVs without having to expand the grid or install permanent charge points in places where there is only a temporary need for power
				</figcaption>
				GM
			</figure>

			<p id="ci946t">
				Hydrogen fuel cells — which use compressed hydrogen as their fuel and release only water vapor — have been in development for decades. GM has condensed its Hydrotec system into a “power cube” encompassing 300 individual hydrogen fuel cells. The cubes can then be deployed in a variety of applications, including mobile generators and temporary EV chargers.
			</p>

			<p>
				 
			</p>

			<p id="FTbnKG">
				The hydrogen-powered generators will only be sold to commercial and military customers to start out, but the automaker said it plans on offering versions for residential use in the future. GM said the ideal application would be at an outdoor concert venue, thanks to the hydrogen generator’s much lower noise profile as compared to gas-powered power sources. Another use case would involve temporary electric vehicle chargers installed at locations where demand for charging hasn’t yet resulted in a permanent charging station.
			</p>

			<figure>
				<p>
					<picture data-cdata='{"asset_id":23179678,"ratio":"*"}' data-cid="site/picture_element-1642622405_8133_36518"> <source sizes="(min-width: 1221px) 846px, (min-width: 880px) calc(100vw - 334px), 100vw" srcset="https://cdn.vox-cdn.com/thumbor/zOSGFvkWRsymQektJgRVjz8DMh0=/0x0:4000x3000/320x0/filters:focal(0x0:4000x3000):format(webp):no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23179678/Palletized_MPG.jpg 320w, https://cdn.vox-cdn.com/thumbor/j-kobPoAJIKyrUbqqP7ComLzXVY=/0x0:4000x3000/520x0/filters:focal(0x0:4000x3000):format(webp):no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23179678/Palletized_MPG.jpg 520w, https://cdn.vox-cdn.com/thumbor/ZRNgmoQun1jxQyH43jtpGO2rUWw=/0x0:4000x3000/720x0/filters:focal(0x0:4000x3000):format(webp):no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23179678/Palletized_MPG.jpg 720w, https://cdn.vox-cdn.com/thumbor/WN4ZXrHq8Zs6K2u42NuyPj7ORcM=/0x0:4000x3000/920x0/filters:focal(0x0:4000x3000):format(webp):no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23179678/Palletized_MPG.jpg 920w, https://cdn.vox-cdn.com/thumbor/S_-Ps3LgrMEPbUpegitwmqR3ezw=/0x0:4000x3000/1120x0/filters:focal(0x0:4000x3000):format(webp):no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23179678/Palletized_MPG.jpg 1120w, https://cdn.vox-cdn.com/thumbor/EARoK2I7arg4AIwaLbyUtkcG-XQ=/0x0:4000x3000/1320x0/filters:focal(0x0:4000x3000):format(webp):no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23179678/Palletized_MPG.jpg 1320w, https://cdn.vox-cdn.com/thumbor/qw7UO78cIgYl1oQyXxfyuritR2M=/0x0:4000x3000/1520x0/filters:focal(0x0:4000x3000):format(webp):no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23179678/Palletized_MPG.jpg 1520w, https://cdn.vox-cdn.com/thumbor/UYn9xwt_YtLX_CnRfBS6oz8IlKE=/0x0:4000x3000/1720x0/filters:focal(0x0:4000x3000):format(webp):no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23179678/Palletized_MPG.jpg 1720w, https://cdn.vox-cdn.com/thumbor/ixLyScbGOpsrSU9LlEHJVrQib70=/0x0:4000x3000/1920x0/filters:focal(0x0:4000x3000):format(webp):no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23179678/Palletized_MPG.jpg 1920w" type="image/webp">  </source></picture>
				</p>

				<p>
					<img alt="Palletized_MPG.jpg" class="ipsImage" data-ratio="75.10" height="540" width="720" src="https://cdn.vox-cdn.com/thumbor/WN4ZXrHq8Zs6K2u42NuyPj7ORcM=/0x0:4000x3000/920x0/filters:focal(0x0:4000x3000):format(webp):no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23179678/Palletized_MPG.jpg">
				</p>

				<figcaption>
					GM’s prototype palletized Mobile Power Generator converts offboard, bulk-stored hydrogen to electricity to quietly and efficiently power military camps and installations with no emissions in operation.
				</figcaption>
				GM
			</figure>

			<p id="EBQkhb">
				“Hydrotec power generators can quickly be deployed for disaster relief,” said Charlie Freese, executive director of GM’s Hydrotec division, in a call with reporters, “or it can provide backup for the electrical grid in areas that are experiencing rolling blackouts.”
			</p>

			<p>
				 
			</p>

			<p id="u08u64">
				GM is planning on offering these generators in multiple sizes for a variety of uses. Each unit will put out power ranging from 60kW to 600kW, depending on size and use case. They also will use a different number of Hydrotec power cubes. The company’s Mobile Power Generator, for example, relies on one power cube, while the Empower rapid chargers will use eight cubes.
			</p>

			<p>
				 
			</p>

			<p id="RFzXuR">
				One of the biggest challenges, though, is the dearth of hydrogen charging and refueling infrastructure. Despite the technology having been in development for decades, there are only a little more than two dozen fueling stations in California, <a href="http://cafcp.org/stationmap" rel="external nofollow">mostly clustered</a> around Los Angeles and the Bay Area. The East Coast is trying to get in on the action. A <a href="http://chfcc.org/existing-and-planned-hydrogen-fueling-stations-northeast-us/" rel="external nofollow">handful of stations</a> are up and running, and more are in the works in New York, New Jersey, Massachusetts, Connecticut, and Rhode Island.
			</p>

			<div>
				<aside id="d9iT9i">
					<p>
						 
					</p>

					<p>
						One of the biggest challenges, though, is the dearth of hydrogen charging and refueling infrastructure
					</p>
				</aside>
			</div>

			<p>
				 
			</p>

			<p id="gEncfQ">
				Hydrogen’s energy content by volume is low, which makes storing hydrogen a challenge because it requires high pressures, low temperatures, or chemical processes to be stored compactly. Overcoming this challenge is important for light-duty vehicles because they often have limited size and weight capacity for fuel storage.
			</p>

			<p>
				 
			</p>

			<p id="aCnJef">
				However, Freese said he was confident that the infrastructure would improve as demand for hydrogen rises. “Hydrogen infrastructure is something that’s building out now,” he said. “There’s a lot of investment going on there.”
			</p>

			<p>
				 
			</p>

			<p id="yApDqr">
				In addition to producing hydrogen for mobile power generation, GM is also working on applying the technology to trucking, rail transportation, and even aerospace. The automaker is <a href="https://www.theverge.com/2021/1/27/22251582/gm-hydrogen-truck-navistar-oneh2-range-date" rel="external nofollow">working with trucking firm Navistar and OneH2</a>, a North Carolina-based hydrogen fuel cell company, to put more hydrogen-powered long-haul trucks on the road. It also has a deal with Liebherr-Aerospace to develop a hydrogen fuel cell power-generation demonstrator system for aircraft. And it’s working on fuel cell systems for Wabtec locomotives.
			</p>
		</div>
	</div>
</div>

<p>
	 
</p>

<p>
	 
</p>

<p>
	<a href="https://www.theverge.com/2022/1/19/22891368/gm-hydrotec-hydrogen-fuel-cell-mobile-power-generators" rel="external nofollow">GM announces plans to make mobile power generators using hydrogen fuel cells</a>
</p>
]]></description><guid isPermaLink="false">3956</guid><pubDate>Wed, 19 Jan 2022 21:21:49 +0000</pubDate></item><item><title>Autonomous battery-powered rail cars could steal shipments from truckers</title><link>https://nsaneforums.com/news/general-news/autonomous-battery-powered-rail-cars-could-steal-shipments-from-truckers-r3951/</link><description><![CDATA[<div data-page="1">
	<div>
		<header>
			<h2 itemprop="description">
				Advances in batteries, autonomy could extend the reach of freight railroads.
			</h2>

			<p>
				<img alt="Parallel_Landscape_cropped-e164261398093" class="ipsImage" data-ratio="62.50" height="405" width="720" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/Parallel_Landscape_cropped-e1642613980939-800x450.jpg">
			</p>
		</header>

		<section>
			<div itemprop="articleBody">
				<figure>
					<figcaption>
						<div>
							Two Parallel Systems rail vehicles transport a container down a test track in Southern California.
						</div>

						<div>
							Parallel Systems
						</div>
					</figcaption>
				</figure>

				<p>
					For the last 200 years, freight trains haven’t changed much; massive locomotives still move relatively dumb freight cars. Certainly, rail fans could argue that plenty has changed—they’re not wrong!—but from a distance, trains work pretty much the same today as they did in the 1800s.
				</p>

				<p>
					 
				</p>

				<p>
					That may change, though, if three former SpaceX engineers have placed their bets properly. Today, their startup, Parallel Systems, has emerged from stealth mode with a prototype vehicle that promises to bring advances in autonomy and battery technology to the relatively staid world of freight railroads. In the process, they hope to not just electrify existing routes but also bring freight rail service to places that don’t have it today.
				</p>

				<p>
					 
				</p>
				Whether their bet pays off will hinge on whether freight railroads and their customers will buy into a new way of operating. Parallel Systems isn’t just taking an existing freight train and <a href="https://arstechnica.com/science/2021/11/can-we-run-our-trains-using-big-batteries/" rel="external nofollow">swapping its diesel-electric locomotive for a battery version</a>. Instead, it’s taking the traction motors and distributing them to every car on the train. It’s how many electric passenger trains operate, but it's a system that has been slow to migrate to the freight world.

				<p>
					 
				</p>

				<p>
					Parallel Systems is going a step further, though. Each of its rail vehicles consists of a battery pack, electric motors, four wheels, and a package of sensors that allow it to operate autonomously. And since a large portion of the world’s freight is shipped via 20-foot containers, Parallel Systems is using the containers themselves to complete the car, bridging the gap between the sets of wheels at either end of a train car, also known as bogies.
				</p>

				<p>
					 
				</p>

				<p>
					Here’s how it works: two vehicles position themselves far enough apart to support the container, which is lowered by a crane. The vehicles then use their short- and long-range cameras to navigate the rails. Because each rail vehicle has everything it needs, it doesn’t have to be part of a long train. In theory, one container supported by two Parallel Systems vehicles could move from origin to destination by itself. In reality, though, they’ll likely end up traveling in platoons. (Parallel Systems doesn’t call them trains because the individual cars aren’t coupled.)
				</p>

				<p>
					 
				</p>

				<p>
					<img alt="Parallel_Microterminal_Illustrated-small" class="ipsImage" data-ratio="75.10" height="399" width="720" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/Parallel_Microterminal_Illustrated-small-980x544.jpg">
				</p>

				<figure>
					<figcaption>
						<div>
							Parallel Systems envisions a series of "microterminals" that would transfer containers to trucks for last-mile delivery.
						</div>

						<div>
							Parallel Systems
						</div>
					</figcaption>
				</figure>

				<p>
					“We think our platoon sizes are ideally between ten and 50 cars,” Matt Soule, CEO of Parallel Systems, told Ars. “With ten, you’re sharing the aerodynamic load over multiple cars, and the benefits of that kind of asymptote out around ten cars. But on the business case side, in terms of serving the volumes that might be there, we think moving in platoons of up to 50 is the max.” 
				</p>

				<p>
					 
				</p>

				<p>
					By modern standards, a 50-car train is pretty short. “Trains have always been long, but they’ve gotten longer in recent years because you get really good unit economics when you do that,” Soule said. “The problem now is that you have the three-mile-long train. Where do you park a train that big? And the answer is 'not that many places.'”
				</p>

				<p>
					 
				</p>

				<p>
					His hope is that, once trains become smaller, railroads will be able to move cargo that would otherwise be handled by trucking companies. “We’re enabling rail to do more miles because when the terminal becomes smaller, you've got more options to put it closer, where your customer and shipper are,” Soule said.
				</p>

				<p>
					 
				</p>

				<p>
					Parallel Systems' rail vehicles can travel up to 500 miles on a charge, and a two-vehicle team can carry a single or double stack of containers holding 64,000 pounds (29,000 kg) each. Its camera-based vision system helps it watch for other trains and obstacles, and Soule thinks the company's sensor suit will be enough to handle the <a href="https://arstechnica.com/cars/2018/12/mining-company-says-first-autonomous-freight-train-network-is-fully-operational/" rel="external nofollow">relatively simple environment</a>. Remote human operators could help cars decide how to deal with edge cases, he said. The startup has a first-generation prototype running on a test track in Southern California, and the company is currently building a revised version. By the third version, Soule hopes to be ready for production.
				</p>
			</div>
		</section>
	</div>
</div>

<div data-page="2">
	<div>
		<section>
			<div itemprop="articleBody">
				<h2>
					New way of doing business
				</h2>

				<p>
					Will the industry be ready by then? Parallel Systems certainly faces a few challenges. For one, its business case to railroads depends on serving locations that are currently underserved by rail. In many cases, tracks have been torn up. If they still exist, they’re often in dire need of repair. 
				</p>

				<p>
					 
				</p>

				<p>
					“You’re going to be limited by where the tracks are, where the rail yards are. Those have been cut back over the last decades—a lot,” <a href="https://www.mtu.edu/cege/people/faculty-staff/faculty/lautala/" rel="external nofollow">Pasi Lautala</a>, director of the Rail Transportation Program at Michigan Tech, told Ars. “All these little tracks to the little places, either they don’t exist or they’re in such a bad shape.”
				</p>

				<p>
					 
				</p>
				Once the tracks are fixed, companies will have to install new infrastructure to transfer the containers to and from the rail cars. None of these challenges is insurmountable, of course, but they’re still barriers.

				<p>
					 
				</p>

				<p>
					The logistics of it all may prove harder to solve. Railroad traffic is controlled by two basic methods: block signaling and positive train control. With block signaling, lines are divvied up into blocks and controlled by dispatchers, while positive train control monitors where trains are on the track using GPS and other technologies. Block signaling is the way most trains are controlled in the US, but positive train control allows trains to run at higher speeds with less distance between them.
				</p>

				<p>
					 
				</p>

				<p>
					<img alt="Parallel_Vehicle_Loaded2-small-980x653.j" class="ipsImage" data-ratio="75.10" height="479" width="720" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/Parallel_Vehicle_Loaded2-small-980x653.jpg">
				</p>

				<figure>
					<figcaption>
						<div>
							Two prototype vehicles prepare for a test run.
						</div>

						<div>
							Parallel Systems
						</div>
					</figcaption>
				</figure>

				<p>
					US railroads have been lagging behind their international peers when it comes to rolling out positive train control. A 2008 law required it to be implemented on 58,000 of the country’s 140,000 miles of track, a task the railroads only just completed at the end of 2020. That still leaves a significant portion without positive train control. “Eventually, [positive train control] might allow you to run trains closer to each other. But not yet, because we still have block-based signal control,” Lautala said. “Your trains are going to have to run a certain distance away from each other,” he said, typically one every two miles. It’s a system that currently favors large trains.
				</p>

				<p>
					 
				</p>

				<p>
					Because of that, and because today’s container shipments typically run long distances without being redistributed, Lautala is not convinced yet that a Parallel Systems approach solves the problems that freight railroads are facing. But he added that “it’s an interesting, intriguing idea.”
				</p>

				<h2>
					Battle for freight
				</h2>

				<p>
					Whether Parallel Systems has the solution, railroads will have to confront their problems eventually if they’re going to expand. “I do think that if the railroads want to grow market share, they have to get into shorter movements,” Lautala said.
				</p>

				<p>
					 
				</p>

				<p>
					They’ll also be confronting a trucking industry that’s facing its own changing future. Autonomous electric trucks promise to slash costs—autonomy alone could cut costs by <a href="https://journals.sagepub.com/doi/full/10.1177/0361198120930228" rel="external nofollow">almost half</a>, and electrification would lower them further. Plus, the two technologies will help the industry cut its carbon emissions. An autonomous electrified trucking fleet could challenge railroads on both cost and pollution, two places rail usually wins easily.
				</p>

				<p>
					 
				</p>

				<p>
					“The rail industry’s edge is that it is less expensive than trucks. But now trucks are going to reduce their cost of operating—what does that mean for the railroad?” Soule said. “That’s what we’re trying to address.”
				</p>
			</div>
		</section>
	</div>
</div>

<p>
	 
</p>

<p>
	 
</p>

<p>
	<a href="https://arstechnica.com/cars/2022/01/moving-more-with-less-freight-startup-bets-on-autonomous-electric-rail-cars/" rel="external nofollow">Autonomous battery-powered rail cars could steal shipments from truckers</a>
</p>
]]></description><guid isPermaLink="false">3951</guid><pubDate>Wed, 19 Jan 2022 21:07:14 +0000</pubDate></item><item><title>Radian announces plans to build one of the holy grails of spaceflight</title><link>https://nsaneforums.com/news/general-news/radian-announces-plans-to-build-one-of-the-holy-grails-of-spaceflight-r3950/</link><description><![CDATA[<header>
	<h2 itemprop="description">
		"We all understand how difficult this is."
	</h2>

	<p>
		<img alt="radian-one-800x450.jpg" class="ipsImage" data-ratio="62.50" height="405" width="720" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/radian-one-800x450.jpg">
	</p>
</header>

<section>
	<div itemprop="articleBody">
		<figure>
			<figcaption>
				<div>
					A rendering of the single-stage-to-orbit Radian One vehicle.
				</div>

				<div>
					Radian Aerospace
				</div>
			</figcaption>
		</figure>

		<p>
			A Washington-state based aerospace company has exited stealth mode by announcing plans to develop one of the holy grails of spaceflight—a single-stage-to-orbit space plane. Radian Aerospace said it is deep into the design of an airplane-like vehicle that could take off from a runway, ignite its rocket engines, spend time in orbit, and then return to Earth and land on a runway.
		</p>

		<p>
			 
		</p>

		<p>
			"We all understand how difficult this is," said Livingston Holder, Radian’s co-founder, chief technology officer, and former head of the Future Space Transportation and X-33 program at Boeing.
		</p>

		<p>
			 
		</p>

		<p>
			On Wednesday, Radian announced that it had recently closed a $27.5 million round of seed funding, led by Fine Structure Ventures. To date, Radian has raised about $32 million and has 18 full-time employees at its Renton, Washington, headquarters.
		</p>

		<p>
			 
		</p>

		<p>
			During an interview with Ars, Holder and Radian CEO Richard Humphrey explained that they realized it would require significantly more funding to build such an ambitious orbital space plane. Funding will pace their development efforts. For that reason, Humphrey said he was not comfortable putting a date on the company's first test flights but said that Radian was aiming to have an operational capability well before the end of the 2020s.
		</p>

		<p>
			 
		</p>

		<p>
			The current design of Radian One calls for taking up to five people and 5,000 pounds of cargo into orbit. The vehicle would have a down-mass capability of about 10,000 pounds and be powered by three liquid-fueled engines. The idea would be to get as close to airline operations as possible, by flying, landing, re-fueling, and flying again.
		</p>

		<p>
			 
		</p>

		<p>
			Since its founding in 2016, Radian has focused on the propulsion and structure of a vehicle that must withstand a variety of thermal and pressure environments. Humphrey said the company has built and tested its first "full-scale" engine. At full power, this cryogenic-fueled engine will have a thrust of about 200,000 pounds.
		</p>

		<p>
			 
		</p>

		<p>
			"We’re still in the leading edges of that work," Humphrey said. "We understand the fundamentals, we can start it, we can stop it, and we're taking a series of small, progressive steps to get to a full capability."
		</p>

		<p>
			 
		</p>

		<p>
			Humphrey, Holder, and the company's other co-founders, Curtis Gifford and Jeff Feige, have a variety of backgrounds at NASA, the US Department of Defense, and various new space companies. They plan to draw upon earlier work by NASA and contractors who have previously attempted to develop a single-stage-to-orbit spacecraft as well as XCOR, which sought to build a suborbital space plane but had to shut down about five years ago due to a lack of funding.
		</p>

		<p>
			 
		</p>

		<p>
			NASA's last serious attempt at building such a space plane came in the late 1990s, with its "Reusable Launch Vehicle Program," which led to the X-33 program. NASA eventually selected a design by Lockheed Martin for the X-33, but this program fizzled out in 2001 as Lockheed and NASA ran into technical problems, and NASA's priorities changed.
		</p>

		<p>
			 
		</p>

		<p>
			Much has changed in the last two decades to make private development of such a vehicle more feasible, Humphrey said. Lightweight aerospace composites were mostly experimental then but are a well-understood technology now. Space launch companies also now regularly "super chill" their liquid propellants to gain more performance during flight, which Radian plans to do.
		</p>

		<p>
			 
		</p>

		<p>
			And perhaps most importantly, in the wake of SpaceX's success with its launch program, there is ever more private capital flowing into spaceflight operations. This means it should be easier for Radian to raise the substantial amounts of money it will need to bring an orbital space plane on line—more than $1 billion, almost certainly—than it would have even five or 10 years ago.
		</p>

		<p>
			 
		</p>

		<p>
			"A long time has passed since the last true attempt at this," Holder said. "The technology has moved forward, and people are willing to fund projects like this."
		</p>

		<p>
			 
		</p>

		<p>
			If Radian can succeed technologically, large markets would likely open. A vehicle like Radian One would be well suited to fly people to commercial space stations in low Earth orbit, which NASA seeks to foster development of by 2030. These planes could also perform Earth observation work and play a role in bringing back space-manufactured goods. There is also the potential for point-to-point travel on Earth.
		</p>

		<p>
			 
		</p>

		<p>
			There can be no question that this is a hugely challenging endeavor that many people have tried before. Will Radian find the right stuff, at the right moment in time? We'd like to think so.
		</p>
	</div>
</section>

<p>
	 
</p>

<p>
	 
</p>

<p>
	<a href="https://arstechnica.com/science/2022/01/radian-announces-plans-to-build-one-of-the-holy-grails-of-spaceflight/" rel="external nofollow">Radian announces plans to build one of the holy grails of spaceflight</a>
</p>
]]></description><guid isPermaLink="false">3950</guid><pubDate>Wed, 19 Jan 2022 21:03:22 +0000</pubDate></item><item><title>Chemical pollution has passed safe limit for humanity, say scientists</title><link>https://nsaneforums.com/news/general-news/chemical-pollution-has-passed-safe-limit-for-humanity-say-scientists-r3933/</link><description><![CDATA[<p>
	<span style="font-size:18px;"><strong>Study calls for cap on production and release as pollution threatens global ecosystems upon which life depends</strong></span>
</p>

<p>
	 
</p>

<p>
	The cocktail of chemical pollution that pervades the planet now threatens the stability of global ecosystems upon which humanity depends, scientists have said.
</p>

<p>
	 
</p>

<p>
	Plastics are of particularly high concern, they said, along with 350,000 synthetic chemicals including pesticides, industrial compounds and antibiotics. Plastic pollution is now found from the summit of Mount Everest to the deepest oceans, and some toxic chemicals, such as PCBs, are long-lasting and widespread.
</p>

<p>
	 
</p>

<p>
	The study concludes that chemical pollution has crossed a “planetary boundary”, the point at which human-made changes to the Earth push it outside the stable environment of the last 10,000 years.
</p>

<p>
	 
</p>

<p>
	Chemical pollution threatens Earth’s systems by damaging the biological and physical processes that underpin all life. For example, pesticides wipe out many non-target insects, which are fundamental to all ecosystems and, therefore, to the provision of clean air, water and food.
</p>

<p>
	 
</p>

<p>
	“There has been a fiftyfold increase in the production of chemicals since 1950 and this is projected to triple again by 2050,” said Patricia Villarrubia-Gómez, a PhD candidate and research assistant at the Stockholm Resilience Centre (SRC) who was part of the study team. “The pace that societies are producing and releasing new chemicals into the environment is not consistent with staying within a safe operating space for humanity.”
</p>

<p>
	 
</p>

<p>
	Dr Sarah Cornell, an associate professor and principal researcher at SRC, said: “For a long time, people have known that chemical pollution is a bad thing. But they haven’t been thinking about it at the global level. This work brings chemical pollution, especially plastics, into the story of how people are changing the planet.”
</p>

<p>
	 
</p>

<p>
	Some threats have been tackled to a larger extent, the scientists said, such as the CFC chemicals that destroy the ozone layer and its protection from damaging ultraviolet rays.
</p>

<p>
	 
</p>

<p>
	Determining whether chemical pollution has crossed a planetary boundary is complex because there is no pre-human baseline, unlike with the climate crisis and the pre-industrial level of CO2 in the atmosphere. There are also a huge number of chemical compounds registered for use – about 350,000 – and only a tiny fraction of these have been assessed for safety.
</p>

<p>
	 
</p>

<p>
	So the research used a combination of measurements to assess the situation. These included the rate of production of chemicals, which is rising rapidly, and their release into the environment, which is happening much faster than the ability of authorities to track or investigate the impacts.
</p>

<p>
	 
</p>

<p>
	The well-known negative effects of some chemicals, from the extraction of fossil fuels to produce them to their leaking into the environment, were also part of the assessment. The scientists acknowledged the data was limited in many areas, but said the weight of evidence pointed to a breach of the planetary boundary.
</p>

<p>
	 
</p>

<p>
	“There’s evidence that things are pointing in the wrong direction every step of the way,” said Prof Bethanie Carney Almroth at the University of Gothenburg who was part of the team. “For example, the total mass of plastics now exceeds the total mass of all living mammals. That to me is a pretty clear indication that we’ve crossed a boundary. We’re in trouble, but there are things we can do to reverse some of this.”
</p>

<p>
	 
</p>

<p>
	Villarrubia-Gómez said: “Shifting to a circular economy is really important. That means changing materials and products so they can be reused, not wasted.”
</p>

<p>
	 
</p>

<p>
	The researchers said stronger regulation was needed and in the future a fixed cap on chemical production and release, in the same way carbon targets aim to end greenhouse gas emissions. Their study was published in the <em>journal Environmental Science &amp; Technology</em>[.]
</p>

<p>
	 
</p>

<p>
	There are growing calls for international action on chemicals and plastics, including the establishment of a global scientific body for chemical pollution akin to the Intergovernmental Panel on Climate Change.
</p>

<p>
	 
</p>

<p>
	Prof Sir Ian Boyd at the University of St Andrews, who was not part of the study, said: “The rise of the chemical burden in the environment is diffuse and insidious. Even if the toxic effects of individual chemicals can be hard to detect, this does not mean that the aggregate effect is likely to be insignificant.
</p>

<p>
	 
</p>

<p>
	“Regulation is not designed to detect or understand these effects. We are relatively blind to what is going on as a result. In this situation, where we have a low level of scientific certainty about effects, there is a need for a much more precautionary approach to new chemicals and to the amount being emitted to the environment.”
</p>

<p>
	 
</p>

<p>
	Boyd, a former UK government chief scientific adviser, warned in 2017 that assumption by regulators around the world that it was safe to use pesticides at industrial scales across landscapes was false.
</p>

<p>
	 
</p>

<p>
	The chemical pollution planetary boundary is the fifth of nine that scientists say have been crossed, with the others being global heating, the destruction of wild habitats, loss of biodiversity and excessive nitrogen and phosphorus pollution.
</p>

<p>
	 
</p>

<p>
	<strong><a href="https://www.theguardian.com/environment/2022/jan/18/chemical-pollution-has-passed-safe-limit-for-humanity-say-scientists" rel="external nofollow">Source</a></strong>
</p>
]]></description><guid isPermaLink="false">3933</guid><pubDate>Tue, 18 Jan 2022 14:33:25 +0000</pubDate></item><item><title>Pfizer and Moderna expect seasonal booster shots after omicron wave</title><link>https://nsaneforums.com/news/general-news/pfizer-and-moderna-expect-seasonal-booster-shots-after-omicron-wave-r3929/</link><description><![CDATA[<header>
	<h2 itemprop="description">
		Seasonal COVID boosters may be combined with flu shots in the future, Moderna says.
	</h2>
</header>

<section>
	<div itemprop="articleBody">
		<p>
			As the US weathers record COVID-19 cases from the ultra-transmissible omicron variant, vaccine makers are thinking about future waves—and the shots that could help prevent them.
		</p>

		<p>
			 
		</p>

		<p>
			Leading mRNA vaccine makers Moderna and Pfizer/BioNTech are currently working up omicron-specific versions of their vaccines, which could be ready in a matter of months. And according to recent interviews, they expect that such boosters will be used as annual shots, which could be given in the fall for the next several years until global transmission dies down.
		</p>

		<p>
			 
		</p>

		<p>
			"I think the reality is that this is going to become an annual vaccination, at least for a period of time," Scott Gottlieb, former Food and Drug Administration commissioner and Pfizer board member, said Sunday on <a href="https://www.cbsnews.com/news/full-transcript-face-the-nation-01-16-2022/" rel="external nofollow">CBS's Face the Nation</a>. "We don't know what the epidemiology of this infection is going to be over the long run, but certainly over the next couple of years, you can envision boosters becoming an annual affair."
		</p>

		<p>
			 
		</p>

		<p>
			It's still unclear what will occur after the towering omicron wave recedes in the US, which is expected to happen in the coming weeks. Omicron could continue to circulate at lower levels after peaking, or another variant (such as delta or a yet-to-be-identified variant) could take over. "I think most people presume it will be omicron," Gottlieb said. "If you can fashion a vaccine that's specific to the variant that's circulating, you probably have the potential to restore a lot of the original promise of the vaccine."
		</p>

		<h2>
			Fourth shots
		</h2>

		<p>
			Pfizer CEO Albert Bourla <a href="https://www.cnbc.com/2022/01/10/covid-vaccine-pfizer-ceo-says-omicron-vaccine-will-be-ready-in-march.html" rel="external nofollow">said last week</a> that his company's omicron-specific booster will be ready in March. This is after the expected peak of the current wave but in time to prepare for an autumn surge. In an interview today with <a href="https://www.timesofisrael.com/pfizer-ceo-virus-will-be-here-for-years-but-this-may-be-last-wave-with-restrictions/" rel="external nofollow">a French TV outlet</a>, Bourla added that, for now, "it's important that people receive the three-dose regimen of Pfizer's coronavirus vaccine, [but they] will likely then require annual boosters, although the immunocompromised could require them every four months."
		</p>

		<p>
			 
		</p>

		<p>
			Moderna, meanwhile, now has its omicron-specific booster dose in Phase III trials. The company is also expecting that the booster could be used for an annual shot. However, Moderna is setting its sights higher with a seasonal shot that would cover seasonal flu and another seasonal respiratory virus, RSV, in addition to COVID-19.
		</p>

		<p>
			 
		</p>

		<p>
			"Our goal is to be able to have a single annual booster so that we don't have compliance issues where people don't want to get two to three shots a winter," Moderna CEO Stéphane Bancel <a href="https://www.politico.eu/article/moderna-hopes-to-market-combined-covid-and-flu-booster-in-2023/" rel="external nofollow">said Monday during a panel at the World Economic Forum</a>. As for when that combination shot could be ready, Bancel said that "the best-case scenario would be the fall of 2023." The mRNA-based flu and RSV vaccines are <a href="https://arstechnica.com/science/2021/07/mrna-vaccine-technology-moves-to-flu-moderna-says-trial-has-begun/" rel="external nofollow">still under development</a>.
		</p>

		<p>
			 
		</p>

		<p>
			Still, it's not yet clear that annual shots will be required—or even if omicron-specific boosters will be needed after the current wave recedes. Existing vaccines have faltered at protecting double-vaccinated people from infection with omicron. And experts say it's too early to know if people who recover from omicron will be well-protected from getting omicron again in the future. But boosters appear to significantly increase antibody responses, and protection remains strong against severe disease, hospitalizations, and death from omicron and all other variants.
		</p>

		<p>
			 
		</p>

		<p>
			For now, US officials have said it's too early to start talking about fourth vaccine doses and future booster drives. In a January 7 press briefing, Director Rochelle Walensky of the Centers for Disease Control and Prevention noted the difficulty in getting people to take the booster doses that are already available to them. "Right now, I think our strategy has to be to maximize the protection of the tens of millions of people who continue to be eligible for a third shot before we starting thinking about what a fourth shot would look like."
		</p>
	</div>
</section>

<p>
	 
</p>

<p>
	 
</p>

<p>
	<a href="https://arstechnica.com/science/2022/01/vaccine-makers-eye-annual-covid-booster-shots-for-foreseeable-future/" rel="external nofollow">Pfizer and Moderna expect seasonal booster shots after omicron wave</a>
</p>
]]></description><guid isPermaLink="false">3929</guid><pubDate>Tue, 18 Jan 2022 02:51:15 +0000</pubDate></item><item><title>Expect more worrisome variants after omicron, scientists say</title><link>https://nsaneforums.com/news/general-news/expect-more-worrisome-variants-after-omicron-scientists-say-r3915/</link><description><![CDATA[<p>
	Get ready to learn more Greek letters. Scientists warn that omicron's whirlwind advance practically ensures it won't be the last version of the coronavirus to worry the world.
</p>

<p>
	 
</p>

<p>
	Every infection provides a chance for the virus to mutate, and omicron has an edge over its predecessors: It spreads way faster despite emerging on a planet with a stronger patchwork of immunity from vaccines and prior illness.
</p>

<p>
	 
</p>

<p>
	That means more people in whom the virus can further evolve. Experts don't know what the next variants will look like or how they might shape the pandemic, but they say there's no guarantee the sequels of omicron will cause milder illness or that existing vaccines will work against them.
</p>

<p>
	 
</p>

<p>
	They urge wider vaccination now, while today's shots still work.
</p>

<p>
	 
</p>

<p>
	"The faster omicron spreads, the more opportunities there are for mutation, potentially leading to more variants," Leonardo Martinez, an infectious disease epidemiologist at Boston University, said.
</p>

<p>
	 
</p>

<p>
	Since it emerged in mid-November, omicron has raced across the globe like fire through dry grass. Research shows the variant is at least twice as contagious as delta and at least four times as contagious as the original version of the virus.
</p>

<p>
	 
</p>

<p>
	Omicron is more likely than delta to reinfect individuals who previously had COVID-19 and to cause "breakthrough infections" in vaccinated people while also attacking the unvaccinated. The World Health Organization reported a record 15 million new COVID-19 cases for the week of Jan. 3-9, a 55% increase from the previous week.
</p>

<p>
	 
</p>

<p>
	Along with keeping comparatively healthy people out of work and school, the ease with which the variant spreads increases the odds the virus will infect and linger inside people with weakened immune systems - giving it more time to develop potent mutations.
</p>

<p>
	 
</p>

<p>
	"It's the longer, persistent infections that seem to be the most likely breeding grounds for new variants," said Dr. Stuart Campbell Ray, an infectious disease expert at Johns Hopkins University. "It's only when you have very widespread infection that you're going to provide the opportunity for that to occur."
</p>

<p>
	 
</p>

<p>
	Because omicron appears to cause less severe disease than delta, its behavior has kindled hope that it could be the start of a trend that eventually makes the virus milder like a common cold.
</p>

<p>
	 
</p>

<p>
	It's a possibility, experts say, given that viruses don't spread well if they kill their hosts very quickly. But viruses don't always get less deadly over time.
</p>

<p>
	 
</p>

<p>
	A variant could also achieve its main goal - replicating - if infected people developed mild symptoms initially, spread the virus by interacting with others, then got very sick later, Ray explained by way of example.
</p>

<p>
	 
</p>

<p>
	"People have wondered whether the virus will evolve to mildness. But there's no particular reason for it to do so," he said. "I don't think we can be confident that the virus will become less lethal over time."
</p>

<p>
	 
</p>

<p style="text-align:center;">
	<img alt="expect-more-worrisome-1.jpg" class="ipsImage" data-ratio="66.67" height="432" width="720" src="https://scx1.b-cdn.net/csz/news/800/2022/expect-more-worrisome-1.jpg" />
</p>

<p style="text-align:center;">
	<span style="font-size:12px;"><em>Steven Grimmett, a microbiologist on the COVID-19 team at the Washington State Department of Health's Public Health Laboratory, is seen through a window of a machine that identifies positive and negative COVID-19 cases, Dec. 7, 2021, in Shoreline, Wash. Scientists are warning that omicron's lightning-fast spread across the globe practically ensures it won't be the last worrisome coronavirus variant. And there's no guarantee the next ones will cause milder illness or that vaccines will work against them. Credit: AP Photo/Ted S. Warren</em></span>
</p>

<p style="text-align:center;">
	 
</p>

<p>
	Getting progressively better at evading immunity helps a virus to survive over the long term. When SARS-CoV-2 first struck, no one was immune. But infections and vaccines have conferred at least some immunity to much of the world, so the virus must adapt.
</p>

<p>
	 
</p>

<p>
	There are many possible avenues for evolution. Animals could potentially incubate and unleash new variants. Pet dogs and cats, deer and farm-raised mink are only a few of the animals vulnerable to the virus, which can potentially mutate within them and leap back to people.
</p>

<p>
	 
</p>

<p>
	Another potential route: With both omicron and delta circulating, people may get double infections that could spawn what Ray calls "Frankenvariants," hybrids with characteristics of both types.
</p>

<p>
	 
</p>

<p>
	When new variants do develop, scientists said it's still very difficult to know from genetic features which ones might take off. For example, omicron has many more mutations than previous variants, around 30 in the spike protein that lets it attach to human cells. But the so-called IHU variant identified in France and being monitored by the WHO has 46 mutations and doesn't seem to have spread much at all.
</p>

<p>
	 
</p>

<p>
	To curb the emergence of variants, scientists stress continuing with public health measures such as masking and getting vaccinated. While omicron is better able to evade immunity than delta, experts said, vaccines still offer protection and booster shots greatly reduce serious illness, hospitalizations and deaths.
</p>

<p>
	 
</p>

<p>
	Anne Thomas, a 64-year-old IT analyst in Westerly, Rhode Island, said she's fully vaccinated and boosted and also tries to stay safe by mostly staying home while her state has one of the highest COVID-19 case rates in the U.S.
</p>

<p>
	 
</p>

<p>
	"I have no doubt at all that these viruses are going to continue to mutate and we're going to be dealing with this for a very long time," she said.
</p>

<p>
	 
</p>

<p>
	Ray likened vaccines to armor for humanity that greatly hinders viral spread even if it doesn't completely stop it. For a virus that spreads exponentially, he said, "anything that curbs transmission can have a great effect." Also, when vaccinated people get sick, Ray said their illness is usually milder and clears more quickly, leaving less time to spawn dangerous variants.
</p>

<p>
	 
</p>

<p>
	Experts say the virus won't become endemic like the flu as long as global vaccination rates are so low. During a recent press conference, WHO Director-General Tedros Adhanom Ghebreyesus said that protecting people from future variants—including those that may be fully resistant to today's shots—depends on ending global vaccine inequity.
</p>

<p>
	 
</p>

<p>
	Tedros said he'd like to see 70% of people in every country vaccinated by mid-year. Currently, there are dozens of countries where less than a quarter of the population is fully vaccinated, according to Johns Hopkins University statistics. And in the United States, many people continue to resist available vaccines.
</p>

<p>
	 
</p>

<p>
	"These huge unvaccinated swaths in the U.S., Africa, Asia, Latin America and elsewhere are basically variant factories," said Dr. Prabhat Jha of the Centre for Global Health Research at St. Michael's Hospital in Toronto. "It's been a colossal failure in global leadership that we have not been able to do this."
</p>

<p>
	 
</p>

<p>
	In the meantime, new variants are inevitable, said Louis Mansky, director of the Institute for Molecular Virology at the University of Minnesota.
</p>

<p>
	 
</p>

<p>
	With so many unvaccinated people, he said, "the virus is still kind of in control of what's going on."
</p>

<p>
	 
</p>

<p>
	<strong><a href="https://medicalxpress.com/news/2022-01-worrisome-variants-omicron-scientists.html" rel="external nofollow">Source</a></strong>
</p>

<p>
	 
</p>
]]></description><guid isPermaLink="false">3915</guid><pubDate>Sun, 16 Jan 2022 14:22:28 +0000</pubDate></item><item><title>A very common virus may be the trigger for multiple sclerosis</title><link>https://nsaneforums.com/news/general-news/a-very-common-virus-may-be-the-trigger-for-multiple-sclerosis-r3882/</link><description><![CDATA[<div data-page="1">
	<div>
		<header>
			<h2 itemprop="description">
				Scientists have long linked virus that causes mono to MS.
			</h2>

			<p>
				<img alt="GettyImages-579216576-800x541.jpeg" class="ipsImage" data-ratio="75.10" height="486" width="720" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/GettyImages-579216576-800x541.jpeg">
			</p>
		</header>

		<section>
			<div itemprop="articleBody">
				<figure>
					<figcaption>
						<div>
							This photomicrograph depicts leukemia cells that contain Epstein Barr virus using an FA staining technique, 1972. Epstein-Barr virus, EBV, is a member of the Herpesvirus family and is one of the most common human viruses.
						</div>

						<div>
							<a href="https://www.gettyimages.com/detail/news-photo/this-photomicrograph-depicts-leukemia-cells-that-contain-news-photo/579216576?adppopup=true" rel="external nofollow">Getty | CDC</a>
						</div>
					</figcaption>
				</figure>

				<p>
					Evidence is mounting that a garden-variety virus that sometimes causes mono in teens is the underlying cause of multiple sclerosis, a rare neurological disease in which the immune system attacks the brain and spinal cord, stripping away protective insulation around nerve cells, called myelin.
				</p>

				<p>
					 
				</p>

				<p>
					It's still unclear how exactly the virus—the Epstein-Barr virus (EBV)—may trigger MS and why MS develops in a tiny fraction of people. About 95 percent of adults have been infected with EBV, which often strikes in childhood. MS, meanwhile, often develops between the ages of 20 and 40 and is estimated to affect <a href="https://www.atlasofms.org/map/global/epidemiology/number-of-people-with-ms" rel="external nofollow">around one million people</a> in the US. Yet, years of evidence have consistently pointed to links between the childhood virus and the chronic demyelinating disease later in life.
				</p>

				<p>
					 
				</p>

				<p>
					With <a href="https://www.science.org/doi/10.1126/science.abj8222?adobe_mc=MCMID%3D36107227026595899443800847584019462033%7CMCORGID%3D242B6472541199F70A4C98A6%2540AdobeOrg%7CTS%3D1642101957&amp;_ga=2.117980748.455214128.1642092864-1788159707.1641828280" rel="external nofollow">a study published today in Science</a>, the link is stronger than ever, and outside experts say the new findings offer further "compelling" evidence that EBV isn't just connected to MS; it's an essential trigger for the disease. The study found, among other things, that people had a 32-fold increase in risk of developing MS following an EBV infection in early adulthood.
				</p>

				<p>
					 
				</p>

				<p>
					"It's a great paper," Dr. Ruth Dobson, a preventive neurology professor and MS expert at Queen Mary University of London, told Ars in an interview. "The evidence just adds up and adds up and adds up… Whilst we don't understand biologically how EBV drives MS and we think about causation theories, really we have the rest of the building blocks in place," said Dobson, who was not involved in the new Science study. "It's another piece of evidence that really solidifies this theory" that EBV triggers MS.
				</p>

				<h2>
					New findings
				</h2>

				<p>
					For the study, researchers led by Harvard neuroepidemiologist Dr. Kjetil Bjornevik mined an exceptionally rich repository of blood serum samples taken from a cohort of more than 10 million active-duty military personnel between 1993 and 2013. The samples were taken from relatively healthy, fit, and young military personnel in the course of standard screenings for infections, particularly HIV.
				</p>

				<p>
					 
				</p>

				<p>
					In the cohort, there were 801 members who developed MS and had banked up to three serum samples prior to their diagnosis. This gave the researchers the unique opportunity to go back in time and examine serum samples from MS patients years before they developed the disease. The researchers could also compare samples from the 801 MS patients to samples from 1,566 cohort members who did not develop MS and could serve as controls.
				</p>

				<p>
					 
				</p>

				<p>
					Of the 801 people who developed MS, all but one had antibodies indicating an EBV infection by the time of their MS diagnosis. And most of those EBV infections occurred earlier in their lives. At the start of the 20-year period, only 35 of the 801 MS patients started out as negative for EBV. By the end of the period, 34 of those 35 developed anti-EBV antibodies—aka seroconverted—prior to their diagnosis.
				</p>

				<p>
					 
				</p>

				<p>
					Bjornevik and colleagues compared those 35 initially EBV-negative personnel with 107 control-group members who also initially tested negative. They found that the rate of seroconversion in the 35 who would go on to develop MS was significantly higher than the rate in the control group—97 percent of the 35 seroconverted prior to diagnosis while only 57 percent of the control group seroconverted during the 20-year period. From that data, the researchers calculated that those who seroconverted had a 32-fold increased risk of developing MS.
				</p>

				<p>
					 
				</p>

				<p>
					It's unclear why the one MS patient did not appear to seroconvert during the study. The authors speculate that, given gaps in sampling, it's possible the person did seroconvert between the last sample and the diagnosis. It's also possible that the person was misdiagnosed with MS or was infected with EBV but for some reason didn't seroconvert. It's also possible that the person had a rare type of MS that was triggered by something besides EBV. Regardless, the authors reasoned that the one outlying case didn't weaken the strong connection between MS and EBV.
				</p>

				<p>
					 
				</p>

				<p>
					But EBV wasn't the only virus the researchers scrutinized. In fact, they screened serum samples for antibodies targeting more than 200 viruses. The screening indicated that the risk of MS did not increase following infection with any other virus besides EBV. Moreover, when the researchers compared the overall antiviral antibody responses in MS patients to those in controls, they found the overall antibody responses were similar. This suggests that there wasn't some sort of underlying immune dysregulation that spurred the development of MS after an EBV infection.
				</p>
			</div>
		</section>
	</div>
</div>

<div data-page="2">
	<div>
		<section>
			<div itemprop="articleBody">
				<h2>
					Past connections
				</h2>

				<p>
					Overall, the study adds to a mound of other data connecting EBV to MS. Similar to the new study, other research has found a two- to three-fold increase in the risk of developing MS after a bout of infectious mononucleosis ("mono"), which is caused by EBV. The virus specifically attacks a type of immune cell called B cells, and after the initial infection the virus remains dormant in those cells for the rest of a person's life. Multiple studies have found EBV-infected B cells in the brains and demyelinated lesions of MS patients. MS patients also sometimes have elevated levels of specific anti-EBV antibodies that target proteins called EBV nuclear antigens. And, currently, one of the most effective treatments for MS is an antibody therapy that targets circulating memory B cells, which happen to harbor dormant EBV.
				</p>

				<p>
					 
				</p>

				<p>
					"There's been a lot of pieces suggesting EBV plays a role in MS," Bjornevik told Ars. "We feel that with this study, we provide compelling evidence that there's actually a causal relationship between EBV and MS… We feel that it's a definite big step forward and it's the most compelling evidence to date."
				</p>

				<p>
					 
				</p>

				<p>
					Dobson and other experts agreed. In an email to Ars, Dr. Helen Tremlett, a neuroepidemiologist and MS expert at the University of British Columbia, called it "an important study" that "provides credible evidence of the relationship between EBV exposure and MS risk." Tremlett was not involved with the new study but noted that she had collaborated with some of the co-authors in the past.
				</p>

				<p>
					 
				</p>

				<p>
					In <a href="https://www.science.org/doi/10.1126/science.abm7930" rel="external nofollow">an accompanying perspective article</a> in Science, Stanford MS expert William Robinson and neurologist Lawrence Steinman wrote that the findings "provide compelling data that implicate EBV as the trigger for the development of MS."
				</p>

				<h2>
					Essential piece of the jigsaw
				</h2>

				<p>
					Robinson and Steinman go on to discuss some of the hypotheses of how EBV may be triggering MS. One hypothesis is that components of EBV—particularly EBV nuclear antigen proteins—may mimic parts of myelin proteins and other proteins in the central nervous system. This could spur the immune system to create cross-reactive antibodies that attack the virus and the body, causing damage over time. Other hypotheses involve EBV-infected B cells spurring the creation of pathogenic immune cells or activating other immune cells that end up causing damage.
				</p>

				<p>
					 
				</p>

				<p>
					While the new data suggests EBV may be necessary for developing MS—i.e. you can't develop MS without first being infected with EBV—it's clearly not the sole factor. It's not sufficient, as scientists like to say. Researchers over the years have identified other factors that are associated with and may contribute to MS development, such as Vitamin D deficiency, smoking, obesity, and UVB exposure. How any of these factors may combine with EBV infection to lead to MS is still under active investigation.
				</p>

				<p>
					 
				</p>

				<p>
					But, as Dobson noted to Ars, finding the initial trigger opens new possibilities for treatments, such as future EBV vaccines and EBV antivirals. "This is a disease we can't cure and even with our best treatments, in the progressive phase people do still get worse," Dobson said. "So, to be able to prevent or have a window into how we might be able to prevent or stop people from getting this disease in the first place would be amazing."
				</p>

				<p>
					 
				</p>

				<p>
					If you talk to MS patients, Dobson added, all they want to do is prevent this disease from affecting their kids. If we could target "that one essential piece of the jigsaw that everybody who develops MS has" and therefore prevent an irreversible neurological disability... "that's really exciting," she said.
				</p>
			</div>
		</section>
	</div>
</div>

<p>
	 
</p>

<p>
	 
</p>

<p>
	<a href="https://arstechnica.com/science/2022/01/a-very-common-virus-may-be-the-trigger-for-multiple-sclerosis/" rel="external nofollow">A very common virus may be the trigger for multiple sclerosis</a>
</p>
]]></description><guid isPermaLink="false">3882</guid><pubDate>Thu, 13 Jan 2022 21:07:37 +0000</pubDate></item><item><title>Ancient Peruvians partied hard, spiked their beer with hallucinogens to win friends</title><link>https://nsaneforums.com/news/general-news/ancient-peruvians-partied-hard-spiked-their-beer-with-hallucinogens-to-win-friends-r3881/</link><description><![CDATA[<div data-page="1">
	<div>
		<header>
			<h2 itemprop="description">
				If you lived in the Central Andes circa 850 CE, you definitely wanted to party with the Wari.
			</h2>

			<p>
				<img alt="wari1-800x529.jpg" class="ipsImage" data-ratio="73.33" height="476" width="720" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/wari1-800x529.jpg">
			</p>
		</header>

		<section>
			<div itemprop="articleBody">
				<figure>
					<figcaption>
						<div>
							A vessel from the Wari site of Conchopata features the tree and its tell-tale seed pods sprouting from the head of the Staff God.
						</div>

						<div>
							J. Ochatoma Paravicino/M.E. Biwer et al., 2022
						</div>
					</figcaption>
				</figure>

				<p>
					Lacing the beer served at their feasts with hallucinogens may have helped an ancient Peruvian people known as the <a href="https://en.wikipedia.org/wiki/Wari_culture" rel="external nofollow">Wari</a> forge political alliances and expand their empire, according to <a href="https://www.cambridge.org/core/journals/antiquity/article/hallucinogens-alcohol-and-shifting-leadership-strategies-in-the-ancient-peruvian-andes/15030A62A428B74805BADF7DB4137298#" rel="external nofollow">a new paper</a> published in the journal Antiquity. Recent excavations at a remote Wari outpost called Quilcapampa unearthed seeds from the vilca tree that can be used to produce a potent hallucinogenic drug. The authors think the Wari held one big final blowout before the site was abandoned.
				</p>

				<p>
					 
				</p>

				<p>
					“This is, to my knowledge, the first finding of vilca at a Wari site where we can get a glimpse of its use,” co-author Matthew Biwer, an archaeobotanist at Dickinson College, <a href="https://gizmodo.com/how-beer-and-drugs-empowered-an-ancient-andean-empire-1848339767" rel="external nofollow">told Gizmodo</a>. “Vilca seeds or residue has been found in burial tombs before, but we could only assume how it was used. These findings point to a more nuanced understanding of Wari feasting and politics and how vilca was implicated in these practices.”
				</p>

				<p>
					 
				</p>

				<p>
					The <a href="https://en.wikipedia.org/wiki/Wari_Empire" rel="external nofollow">Wari empire</a> lasted from around 500 CE to 1100 CE in the central highlands of Peru. There is some debate among scholars as to whether the network of roadways linking various provincial cities constituted a bona fide empire as opposed to a loose economic network. But the Wari's construction of complex, distinctive architecture and the 2013 discovery of an imperial royal tomb lend credence to the Wari's empire status. The culture began to decline around 800 CE, largely due to drought. Many central buildings were blocked up, suggesting people thought they might return if the rains did, and there is archaeological evidence of possible warfare and raiding in the empire's final days as the local infrastructure collapsed and supply chains failed.
				</p>

				<p>
					 
				</p>

				<p>
					Before that, however, the Wari enjoyed a period of relative peace and prosperity, with a capital city (just northeast of today's city of Ayacucho in Peru) that served as the center of the Wari civilization. The use of hallucinogens, particularly a substance derived from the seeds of the vilca tree, was common in the region during the so-called Middle Horizon period, when the Wari empire thrived.
				</p>

				<p>
					 
				</p>

				<p>
					<img alt="wari2-640x430.jpg" class="ipsImage" data-ratio="67.19" height="430" width="640" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/wari2-640x430.jpg">
				</p>

				<figure>
					<figcaption>
						<div>
							Vilca seed recovered from Component II at Quilcapampa (scale in cm).
						</div>

						<div>
							M. Biwer
						</div>
					</figcaption>
				</figure>

				<p>
					<a href="https://en.wikipedia.org/wiki/Anadenanthera_colubrina" rel="external nofollow">Vilca</a> typically grows in the dry tropical forests in the region. The trees produce long legumes filled with thin seeds. The seeds, bark, and other parts of the tree all contain <a href="https://en.wikipedia.org/wiki/N,N-Dimethyltryptamine" rel="external nofollow">DMT</a>, a well-known psychedelic substance that is also found in the <a href="https://en.wikipedia.org/wiki/Ayahuasca" rel="external nofollow">ayahuasca brews</a> of Amazonian tribes. However, the primary active ingredient is <a href="https://en.wikipedia.org/wiki/Bufotenin" rel="external nofollow">bufotenine</a>, the effects of which quickly wear off if the drug is taken orally. So it's usually smoked, ingested in the form of snuff, or used as an enema by those seeking the full hallucinogenic effect. A 4,000-year-old pipe laced with bufotenine residue and related paraphernalia was found in an Incan cave in Argentina in 1999—the oldest archaeological evidence to date for using vilca in South America.
				</p>

				<p>
					 
				</p>

				<p>
					There is also evidence from historical accounts that a juice or tea derived from vilca seeds was sometimes added to <a href="https://en.wikipedia.org/wiki/Chicha" rel="external nofollow">chicha</a>, a fermented beverage made from maize or the fruits of the molle tree native to Peru. This is one way to take vilca orally while still getting a weaker, sustained psychedelic effect, since the beta-carbolines produced during the fermentation of chicha suppress the stomach enzymes that counter the high by deactivating the active compounds. "Collective consumption of vilca-infused beverages is also documented ethnographically, with the more sustained experiences recounted contrasting with the overwhelming hallucinogenic rush produced when consumed in other manners," the authors wrote.
				</p>

				<p>
					 
				</p>

				<p>
					For instance, people of the neighboring state of Tiwanaku were known to mix such hallucinogens with alcohol, specifically maize beer. There are monoliths depicting figures holding a drinking cup in one hand and a snuff tray in another, and smoking or inhaling vilca was part of a long-standing ritual tradition to foster personal spiritual journeys.
				</p>
			</div>
		</section>
	</div>
</div>

<div>
	 
</div>

<div>
	<img alt="wariA-640x420.jpg" class="ipsImage" data-ratio="65.63" height="420" width="640" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/wariA-640x420.jpg">
</div>

<div data-page="2">
	<div>
		<section>
			<div itemprop="articleBody">
				<figure>
					<figcaption>
						<div>
							Molle pit located in Component II at Quilcapampa site (Locus 2707).
						</div>

						<div>
							S. Bautista
						</div>
					</figcaption>
				</figure>

				<p>
					Biwer et al. think the Wari used vilca for a different purpose: to practice statecraft on a smaller, more intimately social scale. The culture was known for hosting elaborate feasts marked by the serving of alcoholic beverages. The remains of maize and molle are common at Wari archaeological sites, and pre-Hispanic serving vessels that were chemically analyzed showed traces of molle beer. Molle was likely the preferred crop for chicha because, unlike maize, it wasn't also grown for food, plus it is drought-tolerant. The drupes are also rich in hydrocarbons that serve as MAO inhibitors. "The hydrocarbons, when combined with the beta-carbolines produced by fermentation, would have heightened the psychotropic effects of vilca," the authors wrote.
				</p>

				<p>
					 
				</p>

				<p>
					There are depictions of vilca seed pods on Wari jars that are about the right size for serving chicha, but until now, there has been a lack of physical evidence supporting the hypothesis. Then archaeologists began excavating a remote Wari outpost called Quilcapampa between 2013 and 2017, likely home to just 100 Wari, even at its peak. They found the expected decorated drinking vessels, ceremonial clothing, stone tablets, and so forth, but no weapons indicating any kind of military presence.
				</p>

				<p>
					 
				</p>

				<p>
					That led the researchers to wonder whether the Wari might have opted for a different political strategy from conquering new regions by force. Perhaps they threw the elaborate feasts as a way of forging strong social ties with the inhabitants of the more remote regions in which they settled. They based this hypothesis on what they discovered in the soil around Quilcapampa. The excavation team collected 51 soil samples from various locations at Quilcapampa and then sifted the soil through a sieve to recover any plant material, which the arid conditions of the valley helped preserve.
				</p>

				<p>
					 
				</p>

				<p>
					The most abundant plant material they found was molle, which isn't surprising given its ubiquity in the region. Hundreds of thousands of molle drupes and stems were collected from all over the site. Fully 99 percent of the drupes didn't have resin and were deformed, strongly suggesting that they had been soaked or boiled to remove sugars—mostly likely to make molle chicha.
				</p>

				<p>
					 
				</p>

				<p>
					<img alt="wari3-640x506.jpg" class="ipsImage" data-ratio="79.06" height="506" width="640" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/wari3-640x506.jpg">
				</p>

				<figure>
					<figcaption>
						<div>
							Carbonized molle drupes presenting evidence for boiling and/or soaking to brew chicha molle (scale in mm).
						</div>

						<div>
							M. Biwer
						</div>
					</figcaption>
				</figure>

				<p>
					The team also recovered 16 vilca seeds, the first ever recovered from a Wari site. Unlike the molle drupes, the seeds were only found in a couple of Wari residential compounds, one of which also included the large pit where the bulk of the molle drupes were recovered. The authors believe molle chicha was likely brewed there. Since there was no snuff paraphernalia recovered from the site, it's most likely that the vilca was added to the chicha. This would be a new method of ingesting vilca, although chemical analysis of any residue still needs to be done to confirm the hypothesis.
				</p>

				<p>
					 
				</p>

				<p>
					“Instead of an abrupt, out-of-body experience, you would have a more elongated high [that] you would be able to enjoy with other people,” co-author Justin Jennings, a Royal Ontario Museum archaeologist who led the excavation, <a href="https://www.science.org/content/article/drug-laced-beer-may-have-forged-ancient-peruvian-empire" rel="external nofollow">told Science</a>. “[The Wari] take something that is an antisocial drug and make it a social one. I see these as boozy family dinners, building social relationships one [feast] at a time. The Wari are telling the locals, ‘Bring the molle, and we’re going to add the special sauce.’”
				</p>

				<p>
					 
				</p>

				<p>
					The trees don't grow naturally near Quilcapampa, so the vilca would have been imported to the Wari site, suggesting that it was a tightly controlled substance. Their guests would have lacked both access to the imported seeds and the knowledge of how to prepare the psychoactive brew.
				</p>

				<p>
					 
				</p>

				<p>
					"By tying their esoteric knowledge of obtaining and using vilca as an additive to molle chicha... Wari leaders were able to legitimatize and maintain their heightened status," the authors concluded. "These individuals were able to offer memorable, collective psychotropic feasts but ensured that they could not be independently replicated."
				</p>

				<p>
					 
				</p>

				<p>
					DOI: Antiquity, 2022. <a href="http://dx.doi.org/10.15184/aqy.2021.177" rel="external nofollow">10.15184/aqy.2021.177</a>  (<a href="http://arstechnica.com/science/news/2010/03/dois-and-their-discontents-1.ars" rel="external nofollow">About DOIs</a>).
				</p>
			</div>
		</section>
	</div>
</div>

<p>
	 
</p>

<p>
	 
</p>

<p>
	<a href="https://arstechnica.com/science/2022/01/ancient-peruvians-partied-hard-spiked-their-beer-with-hallucinogens-to-win-friends/" rel="external nofollow">Ancient Peruvians partied hard, spiked their beer with hallucinogens to win friends</a>
</p>
]]></description><guid isPermaLink="false">3881</guid><pubDate>Thu, 13 Jan 2022 21:01:18 +0000</pubDate></item><item><title>Immune system vs. virus: Why omicron had experts worried from the start</title><link>https://nsaneforums.com/news/general-news/immune-system-vs-virus-why-omicron-had-experts-worried-from-the-start-r3880/</link><description><![CDATA[<div data-page="1">
	<div>
		<header>
			<h2 itemprop="description">
				How the immune system targets viruses and shapes viral evolution.
			</h2>

			<p>
				<img alt="GettyImages-1227506794-800x533.jpg" class="ipsImage" data-ratio="74.03" height="479" width="720" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/GettyImages-1227506794-800x533.jpg">
			</p>
		</header>

		<section>
			<div itemprop="articleBody">
				<figure>
					<figcaption>
						<div>
							Illustration of antibodies responding to an infection of SARS-CoV-2.
						</div>

						<div>
							Getty Images/Kateryna Kon/Science Photo Library
						</div>
					</figcaption>
				</figure>

				<p>
					Right from omicron's first description, researchers were concerned about its variant of the SARS-CoV-2 virus. Looking over the list of mutations it carried, scientists could identify a number that would likely make the variant more infectious. Other mutations were even more worrying, as they would likely interfere with the immune system's ability to recognize the virus, allowing it to pose a risk to those who had been vaccinated or suffered from previous infections.
				</p>

				<p>
					 
				</p>

				<p>
					Buried in the subtext of these worries was a clear implication: scientists could simply look at the sequence of amino acids in the spike protein of a coronavirus and get a sense of how well the immune system would respond to it.
				</p>

				<p>
					 
				</p>

				<p>
					That knowledge is based on years of studying how the immune system operates, combined with a lot of specific information regarding its interactions with SARS-CoV-2. What follows is a description of these interactions, along with their implications for viral evolution and present and future variants.
				</p>

				<h2>
					Ts and Bs
				</h2>

				<p>
					To understand the immune system's function, it's easiest to break its responses into categories. To begin with, there's the innate immune response, which tends to recognize general features of pathogens rather than specific properties of individual bacteria or viruses. The innate response doesn't get fine-tuned by vaccination or prior exposure to a virus, so it's not really relevant to the discussion of variants.
				</p>

				<p>
					 
				</p>

				<p>
					What we're interested in is the adaptive immune response, which recognizes specific features in pathogens and generates a memory that produces a rapid and robust response if the same pathogen is ever seen again. It's the adaptive immune response that we're stimulating with vaccines.
				</p>

				<p>
					 
				</p>

				<p>
					The adaptive response can also be broken into categories. In terms of the relevant immune responses, we care most about those mediated by antibody-producing B cells. The other major part of adaptive immunity, the T cell, uses a completely different mechanism for identifying pathogens. We know a lot less about the T cell response to SARS-CoV-2, but we'll come back to that later. For now, we'll focus on antibodies.
				</p>

				<p>
					 
				</p>

				<p>
					Antibodies are large (in molecular terms) assemblies of four proteins. Most of the proteins are the same in all antibodies, which allows immune cells to interact with them. But each of the four proteins has a variable region that is different in every B cell produced. Many of the variable regions are useless, and others recognize the body's own proteins and get eliminated. But by chance, some antibodies have variable regions that recognize a segment of a protein made by a pathogen.
				</p>

				<p>
					 
				</p>

				<p>
					<img alt="image-980x1015.jpeg" class="ipsImage" data-ratio="75.10" height="540" width="521" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/image-980x1015.jpeg">
				</p>

				<figure>
					<figcaption>
						<div>
							An antibody molecule. Variable areas in the red and blue portions of the molecule combine to form a binding region that can recognize pathogens.
						</div>

						<div>
							<a href="https://www.nist.gov/news-events/news/2018/12/nist-2d-nmr-fingerprinting-study-gives-biopharmaceutical-sector-new-power" rel="external nofollow">NIST</a>
						</div>
					</figcaption>
				</figure>

				<p>
					The portion of the pathogen's protein that the antibody recognizes is called an epitope. Epitopes vary from protein to protein, but they share some features. They have to be on the exterior of the protein, rather than buried in its interior, for the antibody to bump into it in the first place. And they often have amino acids that are polar or have a charge, since these form stronger interactions with the antibody.
				</p>

				<p>
					 
				</p>

				<p>
					You can't simply look at the amino acids in an antibody and tell what it's going to bind to. But if you have sufficient quantities of a specific antibody, it's possible to do what's called "epitope mapping," which involves figuring out precisely where on a protein the antibody is binding. In some cases, this can include a precise list of the amino acids that the antibody recognizes.
				</p>

				<p>
					 
				</p>

				<p>
					In general, having antibodies stuck to a pathogen in the bloodstream makes it easier for the pathogen to be spotted and disposed of by specialized immune cells—for this function, it really doesn't matter where the antibody sticks. But there are also specific interactions that can inactivate a virus in some cases, as we'll see below.
				</p>
			</div>
		</section>
	</div>
</div>

<div data-page="2">
	<div>
		<section>
			<div itemprop="articleBody">
				<h2>
					Antibodies, SARS-CoV-2, and vaccines
				</h2>

				<p>
					Antibodies generated against SARS-CoV-2 recognize proteins that are on the exterior of the virus's coat. In general, that means the spike protein, which allows the virus to latch on to cells and merge with a cell's membrane, depositing the virus's genome inside. There's only one other protein present on the virus's exterior in significant amounts; it simply maintains the virus's structure and doesn't play a specific role in infection. Most vaccines currently in use simply expose the immune system to the spike protein and leave out any additional viral proteins.
				</p>

				<p>
					 
				</p>

				<p>
					The parts of the spike that are commonly recognized by antibodies have been mapped, and they follow a typical pattern. There are hotspots that tend to be targeted by multiple antibodies because they stick out of their surroundings and have lots of charged or polar residues.
				</p>

				<p>
					 
				</p>

				<p>
					<img alt="image.png" class="ipsImage" data-ratio="56.25" height="405" width="720" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/image.png">
				</p>

				<figure>
					<figcaption>
						<div>
							We've mapped epitopes on the spike protein (colored regions) that are recognized by different antibodies.
						</div>

						<div>
							<a href="https://directorsblog.nih.gov/tag/vaccine-design/" rel="external nofollow">University of Texas at Austin</a>
						</div>
					</figcaption>
				</figure>

				<p>
					A number of these hotspots contain epitopes that are recognized by what are called neutralizing antibodies. These antibodies can interfere with the virus's ability to infect new cells. They work because they bind key regions needed for the spike to function—or simply because antibodies are bulky and can get in the way of the spike's interactions with the proteins it attaches to.
				</p>

				<p>
					 
				</p>

				<p>
					These neutralizing antibodies appear to be critical to the immune system's ability to limit the virus. While the immune response has a lot of features beyond the antibody response, a variety of studies have indicated that the levels of neutralizing antibodies present in an individual tend to <a href="https://arstechnica.com/science/2021/05/researchers-show-neutralizing-antibodies-correlate-with-covid-protection/" rel="external nofollow">correlate with protection</a> against infection and severe symptoms. This doesn't mean other antibodies are not important—they can still aid with the clearance of the virus and may limit the severity of the disease. Neutralizing antibodies simply seem to have a more direct relationship with protection.
				</p>

				<p>
					 
				</p>

				<p>
					The immune system does not remain static once it starts producing antibodies. As infections are cleared, the number of antibody-producing cells drops, and many of them get converted to memory cells that can easily be mobilized should the pathogen reappear. This remobilization may not occur quickly enough to prevent reinfection once sufficient time has passed since the initial infection, especially if the immune system is challenged by a different variant of SARS-CoV-2. But it still appears to be enough to prevent serious disease in most cases, and boosters cause a remobilization that is highly effective.
				</p>

				<p>
					 
				</p>

				<p>
					One last note on antibodies before we move on. The genes for a number of neutralizing antibodies have been isolated, and they've been used to create cocktails of neutralizing antibodies that are somewhat helpful to COVID-19 patients if treatment begins early enough. The therapy made by Regeneron is an example of this approach.
				</p>

				<h2>
					Evolution and escape
				</h2>

				<p>
					Mutations in the epitopes that are recognized by anti-spike antibodies have the potential to eliminate their interactions. This can provide an evolutionary pressure that selects for changes specifically in these epitopes. If, because of past infection or vaccination, most people in a population have antibodies that recognize a specific epitope, then a change that alters the epitope and limits that recognition can allow the mutant virus to infect the population.
				</p>

				<p>
					 
				</p>

				<p>
					And there is clearly evidence that this has occurred. Many of the variants we've identified <a href="https://www.science.org/doi/10.1126/science.abl8506" rel="external nofollow">have mutations</a> in the areas known to be recognized by neutralizing antibodies.
				</p>

				<p>
					 
				</p>

				<p>
					<img alt="epitopes-980x636.png" class="ipsImage" data-ratio="75.10" height="467" width="720" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/epitopes-980x636.png">
				</p>

				<figure>
					<figcaption>
						<div>
							Diagram of a portion of the spike protein that antibodies are known to bind to. The items highlighted in red are mutations seen in SARS-CoV-2 variants that interfere with immune recognition.
						</div>

						<div>
							<a href="https://www.science.org/doi/10.1126/science.abl8506#F2" rel="external nofollow">McCallum et. al.</a>
						</div>
					</figcaption>
				</figure>

				<p>
					Fortunately, these mutations generally <a href="https://www.science.org/doi/10.1126/scitranslmed.abm3302" rel="external nofollow">haven't eliminated the immune system's recognition of the virus entirely</a>. The body's antibody response will typically recognize multiple epitopes of the virus. So while an individual mutation may eliminate the recognition of the virus by some antibodies, there are usually others being made that will continue to bind to other epitopes, including antibodies that don't neutralize the virus. The combination of gradually falling levels of antibodies plus reduced epitope recognition has <a href="https://www.nature.com/articles/s41564-021-01041-4" rel="external nofollow">led to breakthrough infections</a>, but the immune response has been sufficient to prevent severe disease, especially when it has been boosted.
				</p>

				<p>
					 
				</p>

				<p>
					These changes, however, can cause problems for a number of therapies that are based on giving COVID-19 patients large numbers of two or three types of antibodies that are known to neutralize the virus. Here, a single change can potentially cut the efficacy of these therapies in half—and antibody therapies have not been especially effective to start with.
				</p>

				<p>
					 
				</p>

				<p>
					A more serious problem is that the virus can continue accumulating mutations in different epitopes. As these accumulate, they gradually reduce the number of antibodies that can effectively recognize the virus. There are potentially limits to this process. Some epitopes may also be essential to the protein's function, and thus difficult to change without damaging the spike protein's ability to mediate new infections. And a very large number of changes can potentially disrupt the basic structure of the protein, eliminating its function entirely.
				</p>

				<p>
					 
				</p>

				<p>
					One of the unfortunate lessons from omicron is that the spike protein can apparently tolerate a large number of mutations and continue to function effectively.
				</p>

				<p>
					 
				</p>

				<p>
					In fact, it was the past work in mapping common epitopes on the spike protein that caused experts to worry about the omicron variant when little more than its genome was understood. It was easy to look for where the mutations in that genome would change the spike protein and see that many mapped to epitope sites, including those recognized by neutralizing antibodies. This was a strong indication that the variant virus was more likely to escape neutralization by antibodies—something that has since <a href="https://www.nature.com/articles/s41586-021-04388-0" rel="external nofollow">been confirmed experimentally</a>.
				</p>
			</div>
		</section>
	</div>
</div>

<div data-page="3">
	<div>
		<section>
			<div itemprop="articleBody">
				<h2>
					The wild card: T cells
				</h2>

				<p>
					Studies of immunity and SARS-CoV-2 have primarily focused on antibodies. This is partly motivated by the fact that levels of neutralizing antibodies correlate well with the degree of protection from severe infections. But it's also because it's relatively simple to measure antibody levels. By contrast, virus-specific T cells are very difficult to characterize. Yet, in part because they recognize the virus through a completely different mechanism, T cells could provide a degree of immunity even if antibody-based protection fails.
				</p>

				<p>
					 
				</p>

				<p>
					Instead of just recognizing only the proteins that are exposed to the blood stream, T cells can potentially recognize every protein made by a cell. That's because cells chop up a small number of the proteins they make and display some of the fragments on their surface. T cells are able to recognize when any of these fragments are unusual, either because the cell has picked up mutations that alter its proteins or because some of the proteins it is making are encoded by a pathogen.
				</p>

				<p>
					 
				</p>

				<p>
					There are several types of T cells that perform different specialized functions. The two major contributors to the immune response to SARS-CoV-2 are what are called helper and killer T cells. When helper T cells recognize a cell that is producing unusual proteins, it starts making lots of signaling molecules that activate other immune cells, including antibody-producing cells.
				</p>

				<p>
					 
				</p>

				<p>
					Killer T cells, by contrast, do exactly what their name implies. When they recognize a cell producing unusual proteins, they kill it. This keeps the cell from producing further pathogens, so it can limit the spread of infections after they start.
				</p>

				<p>
					 
				</p>

				<p>
					A key feature of T cell immunity is that it's much harder for viruses to evolve a way to escape it. Rather than being focused on just the few proteins that are on the surface of a virus, T cells can potentially recognize any protein the virus encodes. So instead of having mutations in just a few key epitopes, evading T cell immunity requires mutations scattered throughout the entire viral genome. It appears that, despite the many mutations in the spike protein of the omicron variant, omicron is still <a href="https://www.nature.com/articles/d41586-022-00063-0" rel="external nofollow">easily recognized by T cells</a>.
				</p>

				<p>
					 
				</p>

				<p>
					The downside is that the most common vaccines only introduce the spike protein, so they don't provide the benefit of this more diversified immunity.
				</p>

				<h2>
					Where things stand
				</h2>

				<p>
					As mentioned above, immunity from severe disease appears to be linked to levels of neutralizing antibodies. Is there any evidence suggesting that immunity based on T cells is also useful? Perhaps the strongest piece of evidence is that some strains of the virus appear to be <a href="https://www.cell.com/iscience/fulltext/S2589-0042(21)01322-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2589004221013225%3Fshowall%3Dtrue" rel="external nofollow">picking up mutations</a> that interfere with T-cell-based immunity. There's also the <a href="https://arstechnica.com/science/2021/12/preliminary-data-suggests-two-doses-of-jj-vaccine-help-with-omicron/" rel="external nofollow">unusual performance of the J&amp;J vaccine</a>, which appears to see a more gradual rise and decay of protection against severe disease. A few studies seem to suggest that this could be the result of a strong T cell response.
				</p>

				<p>
					 
				</p>

				<p>
					Further research is clearly needed to sort out the precise roles of the different arms of the immune system. In the meantime, we know enough about the immune system's response to omicron that we can clearly say a few things. The extensive number of changes in the variant's spike protein reduces the ability of the immune system to recognize it, both in people with <a href="https://www.nature.com/articles/s41586-022-04399-5" rel="external nofollow">prior infections</a> and those who have <a href="https://www.nature.com/articles/s41586-021-04387-1" rel="external nofollow">been vaccinated</a>. But the mutations <a href="https://www.medrxiv.org/content/10.1101/2022.01.02.22268634v1.full.pdf" rel="external nofollow">do not eliminate that ability</a>, and boosters <a href="https://www.researchsquare.com/article/rs-1168453/v1" rel="external nofollow">restore extensive neutralizing activity</a>.
				</p>

				<p>
					 
				</p>

				<p>
					What this has meant in practical terms is that the people who have been vaccinated over six months prior and have since seen their immune system switch over to memory cells are more likely to get a breakthrough infection when a distinct variant such as omicron appears. But they largely remain protected from experiencing a severe case. Booster doses re-establish an active immune response and provide an even greater degree of protection.
				</p>

				<p>
					 
				</p>

				<p>
					That's impressive given the number of relevant differences between omicron and the viral strains that the vaccine was designed to protect against. This suggests that it may take some time before enough mutations end up in a single variant that the effectiveness of the vaccines is severely compromised.
				</p>
			</div>
		</section>
	</div>
</div>

<p>
	 
</p>

<p>
	 
</p>

<p>
	<a href="https://arstechnica.com/science/2022/01/immune-system-vs-virus-why-omicron-had-experts-worried-form-the-start/" rel="external nofollow">Immune system vs. virus: Why omicron had experts worried from the start</a>
</p>
]]></description><guid isPermaLink="false">3880</guid><pubDate>Thu, 13 Jan 2022 20:58:18 +0000</pubDate></item><item><title>High-speed rail construction reveals Roman town in the UK</title><link>https://nsaneforums.com/news/general-news/high-speed-rail-construction-reveals-roman-town-in-the-uk-r3865/</link><description><![CDATA[<header>
	<h2 itemprop="description">
		The town grew from an Iron Age village of about 30 roundhouses alongside a road.
	</h2>

	<p>
		<img alt="site-aerial-view-1-800x533.jpg" class="ipsImage" data-ratio="74.03" height="479" width="720" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/site-aerial-view-1-800x533.jpg">
	</p>
</header>

<section>
	<div itemprop="articleBody">
		<figure>
			<figcaption>
				<div>
					Aerial shots with drone of Blackgrounds Roman archaeological site.
				</div>

				<div>
					HS2
				</div>
			</figcaption>
		</figure>

		<p>
			Archaeologists surveying the planned route of a high-speed railway between London and Birmingham in the UK unearthed the remains of a Roman trading town in what is now South Northamptonshire.
		</p>

		<p>
			 
		</p>

		<p>
			At its height, the town boasted an assortment of workshops and businesses, with long-buried foundations that archaeologists have spent the past year carefully unearthing from the site’s dark—almost black—soil. Artifacts at the site, from jewelry and finely made ceramics to more than 300 Roman coins, hint at ancient affluence. According to archaeologists with the Museum of London Archaeology (MOLA) Headland Infrastructure, most of that wealth probably came from trade along the nearby River Cherwell or the 10-meter-wide stone-paved Roman road running through the middle of the town.
		</p>

		<p>
			 
		</p>

		<p>
			“It indicates that the settlement would have been very busy, with carts simultaneously coming and going to load and unload goods,” said MOLA Headland Infrastructure in a statement.
		</p>

		<h2>
			Life on the Roman frontier
		</h2>

		<p>
			People at the site, now called Blackgrounds for its dark soil, lived on the far-flung western frontier of the Roman Empire, but they lived a distinctly Roman way of life. Rome’s influence here is apparent not just in the Roman coins but in the Roman deities depicted on pottery and on metal weights for scales. Roman-style bronze brooches and the traces of lead-based cosmetics found at the site reveal Roman fashions in daily life. And in the end, at least some of the people who once lived here were cremated and laid to rest in Roman-style urns.
		</p>

		<p>
			 
		</p>

		<p>
			At a larger scale, Roman organization is clear in the layout of the town. Archaeologists noticed a distinct division between a residential district and a more industrial district. There, archaeologists found the remains of workshops, as well as a patch of burned red soil that suggests the presence of a baker, a foundry, or a potter’s kiln.
		</p>

		<p>
			 
		</p>

		<p>
			Other artifacts at Blackgrounds hint at less savory Roman institutions. Half a set of metal shackles may be evidence of either enslaved people or imprisoned criminals. Additional finds include bone dice and gaming pieces, weaving tools, ceramic pots, and pewter dishes.
		</p>

		<div>
			 
		</div>
	</div>
</section>

<div>
	<img alt="excavation-3-1440x959.jpg" class="ipsImage" data-ratio="75.10" height="479" width="720" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/excavation-3-1440x959.jpg">
</div>

<div>
	A team of 80 archaeologists has spent the past year excavating at Blackgrounds.
</div>

<div>
	 
</div>

<div>
	<img alt="excavation-2-1440x958.jpg" class="ipsImage" data-ratio="75.10" height="479" width="720" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/excavation-2-1440x958.jpg">
</div>

<div>
	Archaeologists excavate a Roman-era wall at the site.
</div>

<div>
	 
</div>

<div>
	<img alt="well-4-1440x958.jpg" class="ipsImage" data-ratio="75.10" height="479" width="720" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/well-4-1440x958.jpg">
</div>

<div>
	James West (MOLA Headland), site manager, stands next to a Roman well.
</div>

<div>
	 
</div>

<div>
	<img alt="road-surface-1440x720.jpg" class="ipsImage" data-ratio="75.10" height="360" width="720" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/road-surface-1440x720.jpg">
</div>

<div>
	The paved surface of the Roman road looks much like other Roman roads across the former empire.
</div>

<div>
	 
</div>

<div>
	<img alt="Roman-wall-1440x958.jpg" class="ipsImage" data-ratio="75.10" height="479" width="720" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/Roman-wall-1440x958.jpg">
</div>

<div>
	This Roman-era wall is starting to subside but is in remarkably good shape after at least 1,600 years.
</div>

<div>
	 
</div>

<div>
	<img alt="walls-of-domestic-bldg-1440x958.jpg" class="ipsImage" data-ratio="75.10" height="479" width="720" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/walls-of-domestic-bldg-1440x958.jpg">
</div>

<div>
	This is all that remains of a Roman domestic building.
</div>

<div>
	 
</div>

<div>
	<img alt="red-scorched-earth-1440x810.jpg" class="ipsImage" data-ratio="75.10" height="405" width="720" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/red-scorched-earth-1440x810.jpg">
</div>

<div>
	This red earth suggests that the area was once used for something involving lots of heat, like a foundry, a bakery, or a kiln.
</div>

<div>
	 
</div>

<div>
	<img alt="bone-die-and-gaming-pcs-2-1440x957.jpg" class="ipsImage" data-ratio="75.10" height="478" width="720" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/bone-die-and-gaming-pcs-2-1440x957.jpg">
</div>

<div>
	This lead die and these bone gaming pieces once helped people pass the time and may account for a few of the lost coins found at the site.
</div>

<div>
	 
</div>

<div>
	<img alt="female-deity-scale-weight-1440x958.jpg" class="ipsImage" data-ratio="75.10" height="479" width="720" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/female-deity-scale-weight-1440x958.jpg">
</div>

<div>
	This lead weight would have been used to help weigh items on a scale.
</div>

<div>
	 
</div>

<div>
	<img alt="shackle-1440x958.jpg" class="ipsImage" data-ratio="75.10" height="479" width="720" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/shackle-1440x958.jpg">
</div>

<div>
	This shackle may suggest prisoners or enslaved people at the site.
</div>

<div>
	 
</div>

<div>
	<img alt="cremation-urns-1440x2164.jpg" class="ipsImage" data-ratio="75.10" height="540" width="359" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/cremation-urns-1440x2164.jpg">
</div>

<div>
	Most Romans would be cremated and laid to rest in urns like these, not buried.
</div>

<div>
	 
</div>

<div>
	<img alt="pewter-plate-1440x958.jpg" class="ipsImage" data-ratio="75.10" height="479" width="720" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/pewter-plate-1440x958.jpg">
</div>

<div>
	This pewter plate once held somebody's meal.
</div>

<div>
	 
</div>

<div>
	<img alt="weaving-accessories-1-1440x958.jpg" class="ipsImage" data-ratio="75.10" height="479" width="720" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/weaving-accessories-1-1440x958.jpg">
</div>

<div>
	This comb and pin beater would have been used in weaving.
</div>

<div>
	 
</div>

<div>
	<img alt="decorative-pottery-1440x958.jpg" class="ipsImage" data-ratio="75.10" height="479" width="720" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/decorative-pottery-1440x958.jpg">
</div>

<div>
	These ceramic figurines are some of the decorative pieces found at the site.
</div>

<div>
	 
</div>

<div>
	<img alt="pot-1440x2164.jpg" class="ipsImage" data-ratio="75.10" height="540" width="359" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/pot-1440x2164.jpg">
</div>

<div>
	An archaeologist holds up a Roman pot.
</div>

<h2>
	From Iron Age village to Roman trading town
</h2>

<p>
	Blackgrounds wasn’t always a bustling Roman trading town. Its history stretches back to at least 400 BCE. Archaeologists found the foundations of at least 30 Iron Age roundhouses clustered alongside a road—evidence that people had lived here for centuries before the Romans arrived.
</p>

<p>
	 
</p>

<p>
	There’s no sign that people left the site between the Iron Age and the arrival of the Romans; instead, it’s likely that people lived at Blackgrounds for centuries, generation after generation, and gradually adopted a Romanized way of life. That’s what happened in other communities across Roman Britain and throughout the Roman Empire’s other provinces, after all.
</p>

<p>
	 
</p>

<p>
	Over time, the small Iron Age village expanded into a town, and as trade brought more prosperity, people built stone buildings—and eventually, a stone-paved Roman road “exceptional in its size,” according to the MOLA Headland Infrastructure archaeologists.
</p>

<h2>
	High-speed rail to the past
</h2>

<p>
	It’s not clear exactly what happened at Blackgrounds when Rome pulled out of Britain around 400 CE, but by the 1700s, people living in the nearby villages of Edgcote and Chipping Warden knew the site as an ancient Roman town. Even so, archaeologists were surprised by the scale of what they found.
</p>

<p>
	 
</p>

<p>
	About 80 archaeologists from MOLA Headland Infrastructure have spent the past year excavating and mapping the Blackgrounds site. The majority of the work—careful conservation of the artifacts, along with more detailed study—still lies ahead.
</p>

<p>
	 
</p>

<p>
	Blackgrounds is the largest of more than 100 archaeological sites found and surveyed along the proposed HS2 high-speed railway route since 2018.
</p>

<p>
	 
</p>

<p>
	 
</p>

<p>
	<a href="https://arstechnica.com/science/2022/01/archaeologists-unearth-ancient-roman-town-along-uk-high-speed-rail-route/" rel="external nofollow">High-speed rail construction reveals Roman town in the UK</a>
</p>
]]></description><guid isPermaLink="false">3865</guid><pubDate>Wed, 12 Jan 2022 20:27:07 +0000</pubDate></item><item><title>New images of the International Space Station reveal that it is still a jewel</title><link>https://nsaneforums.com/news/general-news/new-images-of-the-international-space-station-reveal-that-it-is-still-a-jewel-r3864/</link><description><![CDATA[<header>
	<h2 itemprop="description">
		Now that astronauts can fly around the space station again, we can appreciate it anew.
	</h2>

	<p>
		<img alt="51814201646_6dd9839e46_k-800x533.jpg" class="ipsImage" data-ratio="74.03" height="479" width="720" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/51814201646_6dd9839e46_k-800x533.jpg">
	</p>
</header>

<section>
	<div itemprop="articleBody">
		<figure>
			<figcaption>
				<div>
					The International Space Station, as seen in November 2021. Prominent at center in this view are the cymbal-shaped UltraFlex solar arrays of the Northrop Grumman Cygnus space freighter.
				</div>

				<div>
					NASA<a href="https://arstechnica.com/science/2022/01/new-images-of-the-international-space-station-reveal-that-it-is-still-a-jewel/?comments=1" title="68 posters participating" rel="external nofollow"> </a>
				</div>
			</figcaption>
		</figure>

		<p>
			The International Space Station is now more than two decades old. And while primary construction of the orbiting laboratory ended a little more than a decade ago, before the retirement of NASA's space shuttle, the station has continued to evolve with smaller modules and an ever-changing array of visiting spacecraft.
		</p>

		<p>
			 
		</p>

		<p>
			Over this time the station has begun to show its age, being exposed to the extreme hot and cold temperatures of space, a vacuum environment, and micrometeoroid debris. For more than 20 years, these harsh conditions have worn on the station, inducing stress fractures and other damage.
		</p>

		<p>
			 
		</p>

		<p>
			Following the space shuttle's retirement in 2011, NASA lost the ability to fly humans around the station to catalog these changes with highly detailed photographs. But thanks to the emergence of SpaceX's Crew Dragon vehicle, astronauts have started circumnavigating the station once again after undocking and before heading home.
		</p>

		<p>
			 
		</p>

		<p>
			Most recently, the Crew 2 mission led by NASA astronaut Shane Kimbrough undocked from the space station on November 8, and the crew was able to capture multiple views of the space station. NASA's Johnson Space Center recently posted the photos <a href="https://www.flickr.com/photos/nasa2explore/with/51814547213/" rel="external nofollow">on its Flickr page</a>.
		</p>

		<p>
			 
		</p>

		<p>
			<img alt="51814547213_7791e74395_k-1440x960.jpg" class="ipsImage" data-ratio="75.10" height="480" width="720" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/51814547213_7791e74395_k-1440x960.jpg">
		</p>

		<p>
			The orbital complex was flying over 250 miles above the Nile Delta in Egypt when this photograph was taken.
		</p>

		<p>
			 
		</p>

		<p>
			<img alt="51813480592_70b86e5f93_k-1440x960.jpg" class="ipsImage" data-ratio="75.10" height="480" width="720" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/51813480592_70b86e5f93_k-1440x960.jpg">
		</p>

		<p>
			The view of the station from inside Crew Dragon.
		</p>

		<p>
			 
		</p>

		<p>
			<img alt="51814919855_4edd7ddce2_k-1440x960.jpg" class="ipsImage" data-ratio="75.10" height="480" width="720" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/51814919855_4edd7ddce2_k-1440x960.jpg">
		</p>

		<p>
			The station's US segment and portions of the Russian segment are pictured. In addition to the modules where astronauts live and work, several external structures are visible including large white radiators extending from its integrated truss structure and the Alpha Magnetic Spectrometer-2 seen on the far left.
		</p>

		<p>
			 
		</p>

		<p>
			<img alt="51814201756_583e567f2a_k-1440x960.jpg" class="ipsImage" data-ratio="75.10" height="480" width="720" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/51814201756_583e567f2a_k-1440x960.jpg">
		</p>

		<p>
			This view shows the habitable volume of the station (modules arranged vertically through the center) along with white radiators used to dissipate heat and the large solar arrays used to generate electricity.
		</p>

		<p>
			 
		</p>

		<p>
			<img alt="51814543254_732570b111_k-1440x960.jpg" class="ipsImage" data-ratio="75.10" height="480" width="720" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/51814543254_732570b111_k-1440x960.jpg">
		</p>

		<p>
			A good shot showing the scale of the station's new solar arrays.
		</p>

		<p>
			 
		</p>

		<p>
			<img alt="51814542959_424b06b4a8_k-1440x960.jpg" class="ipsImage" data-ratio="75.10" height="480" width="720" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/51814542959_424b06b4a8_k-1440x960.jpg">
		</p>

		<p>
			The Bigelow expandable module can be seen in the middle of this image.
		</p>

		<p>
			 
		</p>

		<p>
			<img alt="51814304398_932812d336_k-1440x960.jpg" class="ipsImage" data-ratio="75.10" height="480" width="720" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/51814304398_932812d336_k-1440x960.jpg">
		</p>

		<p>
			Prominent in this view are the Progress 78 cargo craft, the Soyuz MS-19 crew ship, and the Northrop Grumman Cygnus resupply ship.
		</p>

		<p>
			 
		</p>

		<p>
			<img alt="51814201006_e93b98b15e_k-1440x960.jpg" class="ipsImage" data-ratio="75.10" height="480" width="720" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/51814201006_e93b98b15e_k-1440x960.jpg">
		</p>

		<p>
			The orbital complex was flying 263 miles above the Marshall Islands in the Pacific Ocean when this photograph was taken.
		</p>

		<p>
			 
		</p>
	</div>
</section>

<p>
	Upon spending a few minutes looking at these pictures, one cannot help but be reminded about what an engineering and diplomatic achievement the International Space Station is—a huge and complex machine, living and breathing in low Earth orbit. We are unlikely to see a space vehicle in orbit as large or as capable in our lifetimes.
</p>

<p>
	 
</p>

<p>
	In many ways, the International Space Station offers a hopeful vision for what our future in space could hold. It has brought together the United States and Russia in space, as well as a host of other European nations alongside Japan and Canada. Many of these countries warred in the 20th century. But in this century they have worked together and contributed money and hardware toward the construction of something greater than each nation could have made on its own.
</p>

<p>
	 
</p>

<p>
	With its pioneering experiments on human health and microgravity, too, the space station is providing a template for understanding how humans can live and work and thrive in space for months or even years. Hundreds of people have now lived on the station, providing biological information that will inform future spacecraft and exploration missions.
</p>

<p>
	 
</p>

<p>
	The space station, therefore, offers humanity a pathway toward cooperation and sustainability in spaceflight.
</p>

<p>
	 
</p>

<p>
	Recently, at the urging of NASA Administrator Bill Nelson, the <a href="https://blogs.nasa.gov/spacestation/2021/12/31/biden-harris-administration-extends-space-station-operations-through-2030/" rel="external nofollow">Biden White House agreed</a> to extend the space station to 2030. The United States must still forge agreements with its international partners to keep the station flying for this decade, and there may be some heavy lifting to bring Russia along.
</p>

<p>
	 
</p>

<p>
	But the space station, as these photos show, is definitely worth flying as long as it remains capable of doing so.
</p>

<p>
	 
</p>

<p>
	 
</p>

<p>
	<a href="https://arstechnica.com/science/2022/01/new-images-of-the-international-space-station-reveal-that-it-is-still-a-jewel/" rel="external nofollow">New images of the International Space Station reveal that it is still a jewel</a>
</p>
]]></description><guid isPermaLink="false">3864</guid><pubDate>Wed, 12 Jan 2022 20:18:36 +0000</pubDate></item><item><title>We study ocean temperatures. The Earth just broke a heat increase record</title><link>https://nsaneforums.com/news/general-news/we-study-ocean-temperatures-the-earth-just-broke-a-heat-increase-record-r3861/</link><description><![CDATA[<p>
	<span style="font-size:24px;"><strong>Last year the oceans absorbed heat equivalent to seven Hiroshima atomic bombs detonating each second, 24 hours a day, 365 days a year </strong></span>
</p>

<p>
	 
</p>

<p>
	I was fortunate to play a small part in a new study, just published in the journal Advances in Atmospheric Sciences, which shows that the Earth broke yet another heat record last year. Twenty-three scientists from around the world teamed up to analyze thousands of temperature measurements taken throughout the world’s oceans. The measurements, taken at least 2,000 meters (about 6,500ft) deep and spread across the globe, paint a clear picture: the Earth is warming, humans are the culprit, and the warming will continue indefinitely until we collectively take action to reduce greenhouse gas emissions.
</p>

<p>
	 
</p>

<p>
	We used measurements from the oceans because they are absorbing the vast majority of the heat associated with global warming. In fact, more than 90% of global warming heat ends up in the oceans. I like to say that “global warming is really ocean warming”. If you want to know how fast climate change is happening, the answer is in the oceans.
</p>

<p>
	 
</p>

<p>
	But this paper was not merely an academic exercise. It has tremendous consequences to society and biodiversity on the planet. As oceans warm, they threaten sea life and the many food chains that originate in the sea. Warmer ocean waters make storms more severe. Cyclones and hurricanes become more powerful; rains fall harder, which increases flooding; storms surges are more dangerous; and sea levels rise (one of the major causes of rising sea levels is the expansion of water as it heats).
</p>

<p>
	 
</p>

<p>
	How much did the world’s oceans warm in 2021 compared with the previous year? Well, our data shows that oceans heated by about 14 zettajoules (a zettajoule is 1,000,000,000,000,000,000,000 joules of energy). This is a mind-bending number, so it may help to use analogies. This is the equivalent of 440bn toasters running 24 hours a day, every day of the year. Another way to think about this is that the oceans have absorbed heat equivalent to seven Hiroshima atomic bombs detonating each second, 24 hours a day, 365 days a year. I have plotted the ocean heat, measured since the late 1950s, and the clear, persistent rise over the past three to four decades is unmistakable evidence of an Earth that is out of balance.
</p>

<p>
	 
</p>

<p>
	The oceans are vast, and you need many measurements spread out across the planet to get a good sense of what is happening to the oceans as a whole. This study used hi-tech temperature sensors on autonomous buoys that rise and fall in the ocean waters as they make measurements.
</p>

<p>
	 
</p>

<p>
	These sensors then send the data to laboratories around the world for analysis. In addition, we deployed high-quality temperature sensors from ships, temperatures from stationary buoys, and even strapped sensors to animals so we could measure temperatures from the water they traveled through. Our research was enabled by thousands of in-field researchers who are obtaining and processing the raw data. Without their contribution, studies like this would not be possible.
</p>

<p>
	 
</p>

<p>
	We discovered that the temperatures are not rising uniformly across the planet. We found the fastest warming in the Atlantic, Indian and northern Pacific Oceans. In our work we also explore the question of why this pattern is emerging the way it is. Using climate model simulations, we directly tie various features of the ocean to human emissions of industrial pollution and greenhouse gases. These findings suggest that a similar pattern is likely to persist into the coming decades.
</p>

<p>
	 
</p>

<p>
	The information we used is absolutely crucial for understanding the planet. You could say that we took the Earth’s temperature – and the Earth’s fever is getting worse.
</p>

<p>
	 
</p>

<p>
	I asked my colleague Alexey Mishonov, a research scientist at the University of Maryland, about the implications of these findings. “Our results demonstrated that ocean warming is extensively penetrating deeper layers of the ocean,” Dr Mishonov said. “The resulting increase of the ocean heat content cannot be adequately assessed without real measurements. We need to continue our field missions and collect these data.”
</p>

<p>
	 
</p>

<p>
	My new year’s resolution is to help the planet cool down. It’s getting hot in here and there is no sign things are going to change anytime soon. Collectively, we certainly have the technology to reduce greenhouse gases, but we have never really shown the will.
</p>

<p>
	 
</p>

<p>
	<em>John Abraham is a professor of thermal sciences at the University of St Thomas in Minnesota</em>
</p>

<p>
	 
</p>

<p>
	<strong><a href="https://www.theguardian.com/commentisfree/2022/jan/11/ocean-temperatures-earth-heat-increase-record" rel="external nofollow">Source</a></strong>
</p>
]]></description><guid isPermaLink="false">3861</guid><pubDate>Wed, 12 Jan 2022 14:38:09 +0000</pubDate></item><item><title>Pig heart transplanted to human for the first time</title><link>https://nsaneforums.com/news/general-news/pig-heart-transplanted-to-human-for-the-first-time-r3847/</link><description><![CDATA[<header>
	<h2 itemprop="description">
		Transplant is "compassionate use" rather than part of a clinical trial.
	</h2>

	<section>
		<p itemprop="author creator" itemscope="" itemtype="http://schema.org/Person">
			<img alt="DSC_4194-800x534.jpg" class="ipsImage" data-ratio="74.17" height="480" width="720" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/DSC_4194-800x534.jpg">
		</p>
	</section>
</header>

<section>
	<div itemprop="articleBody">
		<figure>
			<figcaption>
				<div>
					The transplant team with the replacement heart.
				</div>

				<div>
					<a href="https://www.medschool.umaryland.edu/news/2022/University-of-Maryland-School-of-Medicine-Faculty-Scientists-and-Clinicians-Perform-Historic-First-Successful-Transplant-of-Porcine-Heart-into-Adult-Human-with-End-Stage-Heart-Disease.html" rel="external nofollow">The transplant team with the replacement heart.</a>
				</div>
			</figcaption>
		</figure>

		<p>
			On Monday, the University of Maryland School of Medicine <a href="https://www.medschool.umaryland.edu/news/2022/University-of-Maryland-School-of-Medicine-Faculty-Scientists-and-Clinicians-Perform-Historic-First-Successful-Transplant-of-Porcine-Heart-into-Adult-Human-with-End-Stage-Heart-Disease.html" rel="external nofollow">announced</a> that its staff had done the first transplant of a pig's heart into a human. The patient who received it had end-stage heart disease and was too sick to qualify for the standard transplant list. Three days after the procedure, the patient was still alive.
		</p>

		<p>
			 
		</p>

		<p>
			The idea of using non-human organs as replacements for damaged human ones—called xenotransplantation—has a long history, inspired by the fact that there are more people on organ waiting lists than there are donors. And, in recent years, our ability to do targeted gene editing has motivated people to start <a href="https://arstechnica.com/science/2017/08/scientists-de-bug-pig-genome-in-preparation-for-farming-organ-donors/" rel="external nofollow">genetically modifying pigs</a> in order to make them better donors. But the recent surgery wasn't part of a clinical trial, so it shouldn't be viewed as an indication that this approach is ready for widespread safety and efficacy testing.
		</p>

		<p>
			 
		</p>

		<p>
			Instead, the surgery was authorized by the FDA under its "<a href="https://www.fda.gov/news-events/public-health-focus/expanded-access" rel="external nofollow">compassionate use</a>" access program. This allows those faced with life-threatening illnesses to receive investigational treatments that haven't gone through rigorous clinical testing yet.
		</p>

		<p>
			 
		</p>

		<p>
			The heart used for this transplant did come from a genetically modified line that was specifically engineered to reduce the chance of rejection by the human immune system. There are a number of lines that have been engineered with this in mind (there's <a href="https://www.nature.com/articles/s41587-021-00885-9" rel="external nofollow">a review</a> of some of the competing ideas on what to modify). This line was developed by a company called Revivicor (now part of United Therapeutics), but the company doesn't provide any details <a href="https://pipeline.unither.com/product/uheart-xenoheart/description/" rel="external nofollow">on its website</a> of the precise changes made. Searching for Revivicor on ClinicalTrials.gov returns only a single hit that involves a completely different pig line.
		</p>

		<p>
			 
		</p>

		<p>
			So it's difficult to know exactly what genes were modified in these pigs. The University of Maryland's press release indicates that there were three pig genes knocked out to lower its immune profile and avoid rejection, and a fourth knocked out to block "excessive growth" of the porcine cells. In addition, six human genes were inserted into the pigs to enhance the human immune system's tolerance of the foreign cells. While it's easy to speculate on what these genes might be, the potential list of targets is much larger than what has actually been edited.
		</p>

		<p>
			 
		</p>

		<p>
			Given the amount of effort that has gone into generating the pig lines, it was clearly a matter of time before these sorts of transplants were attempted. But the lack of details about the commercially developed heart donor mean that it's difficult to judge this first effort on a scientific level. And the fact that the transplant took place without a transparent plan for assessing the safety of the transplant raises questions of how informative the first effort will be.
		</p>

		<p>
			 
		</p>

		<p>
			From a human standpoint, however, someone who has been in the hospital for months for lack of a properly functioning heart now has one. And its ability to remain functional will likely tell us something.
		</p>
	</div>
</section>

<p>
	 
</p>

<p>
	 
</p>

<p>
	<a href="https://arstechnica.com/science/2022/01/pig-heart-transplanted-to-human-for-the-first-time/" rel="external nofollow">Pig heart transplanted to human for the first time</a>
</p>
]]></description><guid isPermaLink="false">3847</guid><pubDate>Tue, 11 Jan 2022 20:35:32 +0000</pubDate></item><item><title>Did a large impact remix the Moon&#x2019;s interior?</title><link>https://nsaneforums.com/news/general-news/did-a-large-impact-remix-the-moon%E2%80%99s-interior-r3846/</link><description><![CDATA[<header>
	<h2 itemprop="description">
		New model suggests a big impact roiled the Moon's interior, altered its volcanism.
	</h2>

	<p>
		<img alt="SPA-800x450.jpg" class="ipsImage" data-ratio="62.50" height="405" width="720" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/SPA-800x450.jpg">
	</p>
</header>

<section>
	<div itemprop="articleBody">
		<figure>
			<figcaption>
				<div>
					The blue area is the basin formed by the largest impact on the Moon. Additional craters have formed by subsequent impacts.
				</div>

				<div>
					<a href="https://moon.nasa.gov/resources/38/south-pole-aitken-basin/" rel="external nofollow">NASA/GSFC/University of Arizona</a>
				</div>
			</figcaption>
		</figure>

		<p>
			As the Moon coalesced from the debris of an impact early in the Solar System's history, the steady stream of orbital impacts is thought to have formed a magma ocean, leaving the body liquid. That should have allowed its components to mix evenly, creating a roughly uniform body. But with the onset of space exploration, we were finally able to get our first good look at the far side of the Moon.
		</p>

		<p>
			 
		</p>

		<p>
			It turned out to look quite different from the side we were familiar with, with very little in the way of the dark regions, called mare, that dominate the side facing Earth. These differences are also reflected in the chemical composition of the rocks on the different sides. If the whole Moon was once a well-mixed blob of magma, how did it end up with such a major difference between two of its faces? A new study links this difference to the Moon's largest impact crater.
		</p>

		<h2>
			A big crash
		</h2>

		<p>
			The South Pole-Aitken Basin is one of the largest impact craters in the Solar System, but again, we didn't realize it was there until after we put a craft in orbit around the Moon. All we can see from Earth are some of the ridges that are part of the outer crater wall. Most of the 2,500 kilometers of the crater itself extend into the far side of the Moon.
		</p>

		<p>
			 
		</p>

		<p>
			Clearly, the crater formed after the magma ocean period, based on the fact that its features solidified after the impact. But it's also very old, and it could have formed prior to many of the volcanic features we can see on the near side. Intriguingly, the largest concentration of volcanic mare are found in the north of the near side—roughly on the opposite side of the Moon from the impact itself. Could they be related?
		</p>

		<p>
			 
		</p>

		<p>
			It's clear that an impact of this size could have generated a lot of heat within the Moon and potentially influenced or even restarted convection of the materials there. But it's far less clear that this would have produced volcanism so far from the site of impact.
		</p>

		<p>
			 
		</p>

		<p>
			To understand the situation better, a team of Chinese researchers built a model of the Moon's interior. This model combined software that could simulate the impact with models of the Moon's interior that could take into account the heating and additional material of the impact and the gravitational influence of the nearby Earth.
		</p>

		<h2>
			A big churn
		</h2>

		<p>
			As expected, the model shows that the heat derived from the impact does indeed restart convection within the interior of the Moon. But it doesn't restart evenly. That's because the body that created the crater also injects a lot of material into the interior of the Moon, and that material gradually spreads out from the site of impact in all directions. For a large portion of the Moon's interior, this disrupts organized convection.
		</p>

		<p>
			 
		</p>

		<p>
			This organized convection is what allows warmer, deep material to make its way to the surface and draws cooler material from the surface to the interior. The net result is that warm, deep material only makes its way closer to the surface on the side opposite the impact crater. On the Moon, this material also contains higher concentrations of radioactive isotopes, which will keep it warm for much longer, powering the extended period of volcanism that created the mare.
		</p>

		<p>
			 
		</p>

		<p>
			Not every impact will produce this sort of effect. If the angle of an impact is too shallow, the spread of material isn't wide enough to create a large asymmetry. And the details of the asymmetry are sensitive to the size of the impactor and the viscosity of the material it injects into the lunar interior.
		</p>

		<p>
			 
		</p>

		<p>
			Obviously, this sort of complicated mechanism requires a lot of things to go right, so researchers will probably want to recheck this work with independent convection models. And the authors of the study suggest that looking at the rocks near the Chang'e-5 landing site on the northern part of the near side may give us a greater sense of the composition of the materials that erupted there.
		</p>

		<p>
			 
		</p>

		<p>
			But as the authors note, there are several competing models to explain the asymmetry, so we'll have to wait for scientists to compare the models to see if there are any obvious differences in what they produce. And then we'll have to see if we can reasonably expect to get any relevant evidence from the Moon.
		</p>

		<p>
			 
		</p>

		<p>
			Nature Geoscience, 2022. DOI: <a href="http://dx.doi.org/10.1038/s41561-021-00872-4" rel="external nofollow">10.1038/s41561-021-00872-4</a>  (<a href="http://arstechnica.com/science/news/2010/03/dois-and-their-discontents-1.ars" rel="external nofollow">About DOIs</a>).
		</p>
	</div>
</section>

<p>
	 
</p>

<p>
	 
</p>

<p>
	<a href="https://arstechnica.com/science/2022/01/did-a-large-impact-remix-the-moons-interior/" rel="external nofollow">Did a large impact remix the Moon’s interior?</a>
</p>
]]></description><guid isPermaLink="false">3846</guid><pubDate>Tue, 11 Jan 2022 20:31:59 +0000</pubDate></item><item><title>All hail the Ariane 5 rocket, which doubled the Webb telescope&#x2019;s lifetime</title><link>https://nsaneforums.com/news/general-news/all-hail-the-ariane-5-rocket-which-doubled-the-webb-telescope%E2%80%99s-lifetime-r3837/</link><description><![CDATA[<header>
	<h2 itemprop="description">
		"It would have been criminal not to do it."
	</h2>
</header>

<section>
	<div itemprop="articleBody">
		<figure>
			<img alt="The Ariane 5 rocket, with the James Webb Space Telescope, at its launch site in French Guiana. " data-ratio="74.03" src="https://cdn.arstechnica.net/wp-content/uploads/2022/01/53070_A4-800x533.jpg">
			<figcaption>
				<div>
					<a data-height="1000" data-width="1500" href="https://cdn.arstechnica.net/wp-content/uploads/2022/01/53070_A4.jpg" rel="external nofollow">Enlarge</a> / The Ariane 5 rocket, with the James Webb Space Telescope, at its launch site in French Guiana.
				</div>

				<div>
					ESA/S. Corvaja
				</div>
			</figcaption>
		</figure>

		<p>
			There were two stunningly good pieces of news about the James Webb Space Telescope this weekend. One was widely reported—that after an intricate, two-week process, the telescope <a href="https://arstechnica.com/science/2022/01/remarkably-nasa-has-completed-deployment-of-the-webb-space-telescope/" rel="external nofollow">completed its deployment</a> without any difficulties. The next steps toward science operations are more conventional.
		</p>

		<p>
			 
		</p>

		<p>
			The other piece of news, less well-covered but still important, emerged during a news conference on Saturday. NASA's Mission Systems Engineer for the Webb telescope, Mike Menzel, said the agency had completed its analysis of how much "extra" fuel remained on board the telescope. Roughly speaking, Menzel said, Webb has enough propellant on board for 20 years of life.
		</p>

		<p>
			 
		</p>

		<p>
			This is twice the conservative pre-launch estimate for Webb's lifetime of a decade, and it largely comes down to the performance of the European Ariane 5 rocket that launched Webb on a precise trajectory on Christmas Day.
		</p>

		<p>
			 
		</p>

		<p>
			Prior to launch, the telescope was fueled with 240 liters of hydrazine fuel and dinitrogen tetroxide oxidizer. Some of this fuel was needed for course adjustments along the journey to the point in space, about 1.5 million km from Earth, where Webb will conduct science observations. The remainder will be used at Webb's final orbit around the L2 Lagrange point for station-keeping and to maintain its orbit.
		</p>

		<p>
			 
		</p>

		<p>
			So every kilogram of fuel saved on Webb's journey to the Lagrange point could be used to extend its life there. Because ten years seemed like a fairly short operational period for such an expensive and capable space telescope, NASA had already been contemplating a costly and risky robotic refueling mission. But now that should not be necessary, as Webb has at least two decades of life.
		</p>

		<p>
			 
		</p>

		<p>
			A lot of this comes down to the performance of the venerable Ariane 5 rocket. NASA and the European Space Agency reached an agreement more than a decade ago by which Europe would use its reliable Ariane 5 rocket to lift the telescope into space, and in exchange, European scientists would get time to use the telescope.
		</p>

		<p>
			 
		</p>

		<p>
			During an interview with <a href="https://www.interplanetary.org.uk/" rel="external nofollow">The Interplanetary Podcast</a>, Ariane 5 program manager Rudiger Albat explained how European rocket scientists approached the Webb launch. Each Ariane 5 vehicle is interchangeable, but engineers and technicians involved in the production of the rocket know which components are going on which rocket. So when they were building a part of Webb, an engineer might say, "I'll take a second look" to make sure the piece was the best it could be.
		</p>

		<p>
			 
		</p>

		<p>
			The Ariane 5 program also selected the best components for Webb based upon pre-flight testing. For example, for the Webb-designated rocket, the program used a main engine that had been especially precise during testing. "It was one of the best Vulcain engines that we've ever built," Albat said. "It has very precise performance. It would have been criminal not to do it."
		</p>

		<p>
			 
		</p>

		<p>
			A similar attitude was taken toward other components, including the solid rocket motors that were used to build the Ariane 5 that launched two weeks ago.
		</p>

		<p>
			 
		</p>

		<p>
			Albat admitted that the days prior to launch were exhausting and nerve-wracking. But soon after the launch, Albat said he and the entire European space community could take pride as Webb took flight and began to unfurl its wings. Now, he said, "I feel totally relaxed." The same can be said for a lot of scientists who have been watching Webb's development for two decades.
		</p>
	</div>
</section>

<p>
	 
</p>

<p>
	 
</p>

<p>
	<a href="https://arstechnica.com/science/2022/01/all-hail-the-ariane-5-rocket-which-doubled-the-webb-telescopes-lifetime/" rel="external nofollow">All hail the Ariane 5 rocket, which doubled the Webb telescope’s lifetime</a>
</p>
]]></description><guid isPermaLink="false">3837</guid><pubDate>Mon, 10 Jan 2022 20:24:19 +0000</pubDate></item><item><title>Australia's New South Wales sees deadliest day of pandemic</title><link>https://nsaneforums.com/news/general-news/australias-new-south-wales-sees-deadliest-day-of-pandemic-r3835/</link><description><![CDATA[<p>
	Australia's New South Wales state reported 16 deaths on Sunday in its deadliest day of the pandemic, even as it relaxed rules to allow some essential workers in isolation to return to work if they are asymptomatic.
</p>

<p>
	 
</p>

<p>
	Just over 30,000 new cases were reported in Australia's most populous state, forcing those people to join more than 200,000 others in isolation.
</p>

<p>
	 
</p>

<p>
	No statistics are kept to determine how many of those are essential workers in the food and manufacturing sectors. But some employers say up to half of their workers have been furloughed after coming into contact with a positive case.
</p>

<p>
	 
</p>

<p>
	Shoppers have reported empty shelves in many supermarkets because of the omicron outbreak's impact on food processing and supply chains.
</p>

<p>
	 
</p>

<p>
	"Critical workers in the food logistics and manufacturing sectors furloughed as close contacts will be permitted to leave self-isolation to attend work if they have no symptoms of COVID-19, to ensure the state has continued access to essential goods," New South Wales Health said in a statement on Sunday.
</p>

<p>
	 
</p>

<p>
	The workers can only leave self-isolation if their employer decides their absence poses a high risk of disruption to the delivery of critical services and if they are not able to work from home.
</p>

<p>
	 
</p>

<p>
	Returning workers will have to wear masks and comply with risk-management strategies required by their employers, including daily rapid antigen tests. If they test positive, they will have to return to isolation.
</p>

<p>
	 
</p>

<p>
	The rule change applies in agriculture to bio-security and food safety personnel undertaking critical duties; in manufacturing to the production of food, beverages, groceries, cleaning and sanitary products; and in transport to food logistics and delivery.
</p>

<p>
	 
</p>

<p>
	The 16 people who died Sunday included eight women and eight men aged in their 60s, 70s, 80s and 90s, NSW Health said. The figure tops the previous record of 15 deaths, which has been reached twice, on Sept. 29 and Oct. 1 last year.
</p>

<p>
	 
</p>

<p>
	There were 1,927 people in hospitals, including 151 people in intensive care.
</p>

<p>
	 
</p>

<p>
	Victoria state reported 44,155 new cases on Sunday, including 22,051 from rapid antigen tests and 22,104 from PCR tests. Of those cases, 9,000 were from rapid antigen tests conducted on Saturday while more than 13,000 were done on previous days and reported Sunday.
</p>

<p>
	 
</p>

<p>
	The numbers do not necessarily reflect the true spread of the virus as they only count the number of recorded cases.
</p>

<p>
	 
</p>

<p>
	Screening carried out by health authorities showed that around 80% of new cases were the omicron variant.
</p>

<p>
	 
</p>

<p>
	Victoria recorded eight deaths on Sunday, but Australia Health Minister Greg Hunt said cases of severe illness are relatively low amid the spread of omicron.
</p>

<p>
	 
</p>

<p>
	<strong><a href="https://medicalxpress.com/news/2022-01-australia-south-wales-deadliest-day.html" rel="external nofollow">Source</a></strong>
</p>
]]></description><guid isPermaLink="false">3835</guid><pubDate>Mon, 10 Jan 2022 01:45:01 +0000</pubDate></item><item><title>Detailed Footage Finally Reveals What Triggers Lightning</title><link>https://nsaneforums.com/news/general-news/detailed-footage-finally-reveals-what-triggers-lightning-r3833/</link><description><![CDATA[<div>
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				<p>
					During a summer storm in 2018, a momentous lightning bolt flashed above a network of radio telescopes in the Netherlands. The telescopes’ detailed recordings, which were processed only recently, reveal something no one has seen before: lightning actually starting up inside a thundercloud.
				</p>

				<p>
					 
				</p>

				<p>
					In <a data-event-click='{"element":"ExternalLink","outgoingURL":"https://www.essoar.org/doi/10.1002/essoar.10508882.1"}' data-offer-url="https://www.essoar.org/doi/10.1002/essoar.10508882.1" href="https://www.essoar.org/doi/10.1002/essoar.10508882.1" rel="external nofollow" target="_blank">a new paper</a> that will soon be published in the journal Geophysical Research Letters, researchers used the observations to settle a long-standing debate about what triggers lightning—the first step in the mysterious process by which bolts arise, grow and propagate to the ground. “It’s kind of embarrassing. It’s the most energetic process on the planet, we have religions centered around this thing, and we have no idea how it works,” said <a data-event-click='{"element":"ExternalLink","outgoingURL":"https://www.rug.nl/staff/b.h.hare/research"}' data-offer-url="https://www.rug.nl/staff/b.h.hare/research" href="https://www.rug.nl/staff/b.h.hare/research" rel="external nofollow" target="_blank">Brian Hare</a>, a lightning researcher at the University of Groningen and a co-author of the new paper.
				</p>

				<p>
					 
				</p>

				<p>
					The schoolbook picture is that, inside a thundercloud, hail falls as lighter ice crystals rise. The hail rubs off the ice crystals’ negatively charged electrons, leading the top of the cloud to become positively charged while the bottom becomes negatively charged. This creates an electric field that grows until a gigantic spark jumps across the sky.
				</p>

				<div data-event-boundary="click" data-event-click='{"pattern":"CNEInterludeEmbed"}' data-in-view='{"pattern":"CNEInterludeEmbed"}' data-include-experiments="true">
					 
				</div>

				<p>
					Yet the electric fields inside clouds are about 10 times too weak to create sparks. “People have been sending balloons, rockets and airplanes into thunderstorms for decades and never seen electric fields anywhere near large enough,” said <a data-event-click='{"element":"ExternalLink","outgoingURL":"https://ceps.unh.edu/person/joseph-dwyer"}' data-offer-url="https://ceps.unh.edu/person/joseph-dwyer" href="https://ceps.unh.edu/person/joseph-dwyer" rel="external nofollow" target="_blank">Joseph Dwyer</a>, a physicist at the University of New Hampshire and a co-author on the new paper who has puzzled over the origins of lightning for over two decades. “It’s been a real mystery how this gets going.”
				</p>

				<p>
					 
				</p>

				<p>
					A big impediment is that clouds are opaque; even the best cameras can’t peek inside to see the moment of initiation. Until recently, this left scientists little choice but to venture into the storm—something they’ve been trying since Benjamin Franklin’s famous kite experiment of 1752. (According to a contemporaneous account, Franklin attached a key to a kite and flew it beneath a thundercloud, observing that the kite became electrified.) More recently, weather balloons and rockets have offered snapshots of the interior, but their presence tends to interfere with the data by artificially creating sparks that wouldn’t naturally occur. “For a long time we really have not known what the conditions are inside a thunderstorm at the time and location that lightning initiates,” said Dwyer.
				</p>

				<div>
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						<img alt="Quanta-GettyImages-1345009975.jpg" class="ipsImage" data-ratio="75.10" height="480" width="720" src="https://media.wired.com/photos/61d8acfa92c6940d76c1e943/master/w_1600,c_limit/Quanta-GettyImages-1345009975.jpg">
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							<figcaption data-event-boundary="click" data-event-click='{"pattern":"Caption"}' data-in-view='{"pattern":"Caption"}' data-include-experiments="true">
								The opacity of stormclouds has until recently prevented scientists from seeing how lightning initiates.Photograph: George Rose/Getty Images
							</figcaption>
						</figure>
					</div>

					<div data-node-id="xlp17">
						 
					</div>
				</div>
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		</div>
	</div>
</div>

<div>
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				<p>
					So Dwyer and his team turned to the Low Frequency Array (LOFAR), a network of thousands of small radio telescopes mostly in the Netherlands. LOFAR usually gazes at distant galaxies and exploding stars. But according to Dwyer, “it just so happens to work really well for measuring lightning, too.”
				</p>

				<div data-attr-viewport-monitor="inline-recirc" data-event-boundary="click" data-event-click='{"pattern":"InlineRecirc"}' data-in-view='{"pattern":"InlineRecirc"}' data-include-experiments="true">
					 
				</div>

				<p>
					When thunderstorms roll overhead, there’s little useful astronomy that LOFAR can do. So instead, the telescope tunes its antennas to detect a barrage of a million or so radio pulses that emanate from each lightning flash. Unlike visible light, radio pulses can pass through thick clouds.
				</p>

				<p>
					 
				</p>

				<p>
					Using radio detectors to map lightning isn’t new; purpose-built radio antennas have <a data-event-click='{"element":"ExternalLink","outgoingURL":"https://www.nmt.edu/research/organizations/langmuir.php"}' data-offer-url="https://www.nmt.edu/research/organizations/langmuir.php" href="https://www.nmt.edu/research/organizations/langmuir.php" rel="external nofollow" target="_blank">long observed storms in New Mexico</a>. But those images are low-resolution or only in two dimensions. LOFAR, a state-of-the-art astronomical telescope, can map lighting on a meter-by-meter scale in three dimensions, and with a frame rate 200 times faster than previous instruments could achieve. “The LOFAR measurements are giving us the first really clear picture of what’s happening inside the thunderstorm,” said Dwyer.
				</p>

				<p>
					 
				</p>

				<p>
					A materializing lightning bolt produces millions of radio pulses. To reconstruct a 3D lightning image from the jumble of data, the researchers employed an algorithm similar to one used in the Apollo moon landings. The algorithm continuously updates what’s known about an object’s position. Whereas a single radio antenna can only indicate the rough direction of the flash, adding data from a second antenna updates the position. By steadily looping in thousands of LOFAR’s antennas, the algorithm constructs a clear map.
				</p>

				<p>
					 
				</p>

				<p>
					When the researchers analyzed the data from the August 2018 lightning flash, they saw that the radio pulses all emanated from a 70-meter-wide region deep inside the storm cloud. They quickly inferred that the pattern of pulses supports one of the two leading theories about how the most common type of lightning gets started.
				</p>

				<p>
					 
				</p>

				<p>
					<a data-event-click='{"element":"ExternalLink","outgoingURL":"http://www.phy.olemiss.edu/~jgladden/phys510/spring06/Gurevich.pdf"}' data-offer-url="http://www.phy.olemiss.edu/~jgladden/phys510/spring06/Gurevich.pdf" href="http://www.phy.olemiss.edu/~jgladden/phys510/spring06/Gurevich.pdf" rel="external nofollow" target="_blank">One idea</a> holds that cosmic rays—particles from outer space—collide with electrons inside thunderstorms, triggering electron avalanches that strengthen the electric fields.
				</p>

				<p>
					 
				</p>

				<p>
					The new observations point to the <a data-event-click='{"element":"ExternalLink","outgoingURL":"https://agupubs.onlinelibrary.wiley.com/doi/abs/10.1029/JC081i021p03671"}' data-offer-url="https://agupubs.onlinelibrary.wiley.com/doi/abs/10.1029/JC081i021p03671" href="https://agupubs.onlinelibrary.wiley.com/doi/abs/10.1029/JC081i021p03671" rel="external nofollow" target="_blank">rival theory</a>. It starts with clusters of ice crystals inside the cloud. Turbulent collisions between the needle-shaped crystals brush off some of their electrons, leaving one end of each ice crystal positively charged and the other negatively charged. The positive end draws electrons from nearby air molecules. More electrons flow in from air molecules that are farther away, forming ribbons of ionized air that extend from each ice crystal tip. These are called streamers.
				</p>

				<p>
					 
				</p>

				<p>
					Each crystal tip gives rise to hordes of streamers, with individual streamers branching off again and again. The streamers heat the surrounding air, ripping electrons from air molecules en masse so that a larger current flows onto the ice crystals. Eventually a streamer becomes hot and conductive enough to turn into a leader—a channel along which a fully fledged streak of lightning can suddenly travel.
				</p>

				<p>
					 
				</p>

				<p>
					“This is what we’re seeing,” said <a data-event-click='{"element":"ExternalLink","outgoingURL":"https://eos.unh.edu/person/christopher-sterpka"}' data-offer-url="https://eos.unh.edu/person/christopher-sterpka" href="https://eos.unh.edu/person/christopher-sterpka" rel="external nofollow" target="_blank">Christopher Sterpka</a>, first author on the new paper. In a movie showing the initiation of the flash that the researchers made from the data, radio pulses grow exponentially, likely because of the deluge of streamers. “After the avalanche stops, we see a lightning leader nearby,” he said. In recent months, Sterpka has been compiling more lightning initiation movies that look similar to the first.
				</p>
			</div>
		</div>
	</div>

	<div>
		 
	</div>
</div>

<div>
	<div>
		<div data-journey-hook="client-content" data-testid="BodyWrapper">
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				<p>
					The key role of ice crystals dovetails with <a data-event-click='{"element":"ExternalLink","outgoingURL":"https://agu.confex.com/agu/fm21/meetingapp.cgi/Paper/917688"}' data-offer-url="https://agu.confex.com/agu/fm21/meetingapp.cgi/Paper/917688" href="https://agu.confex.com/agu/fm21/meetingapp.cgi/Paper/917688" rel="external nofollow" target="_blank">recent findings</a> that lightning activity dropped by more than 10 percent during the first three months of the Covid-19 pandemic. Researchers attribute this drop to lockdowns, which led to fewer pollutants in the air, and thus fewer nucleation sites for ice crystals.
				</p>

				<div data-attr-viewport-monitor="inline-recirc" data-event-boundary="click" data-event-click='{"pattern":"InlineRecirc"}' data-in-view='{"pattern":"InlineRecirc"}' data-include-experiments="true">
					 
				</div>

				<p>
					“The steps set by LOFAR are certainly very significant,” said <a data-event-click='{"element":"ExternalLink","outgoingURL":"https://homepages.cwi.nl/~ebert/index.shtml"}' data-offer-url="https://homepages.cwi.nl/~ebert/index.shtml" href="https://homepages.cwi.nl/~ebert/index.shtml" rel="external nofollow" target="_blank">Ute Ebert</a>, a physicist at the National Research Institute for Mathematics and Computer Science and Eindhoven University of Technology in the Netherlands who studies lightning initiation but was not involved in the new work. She said LOFAR’s initiation movies offer a framework from which to build accurate lightning models and simulations, which until now have been held back by a lack of high-resolution data.
				</p>

				<p>
					 
				</p>

				<p>
					Ebert notes, however, that despite its resolution, the initiation movie described in the new paper does not directly image ice particles ionizing the air—it only shows what happens immediately afterward. “Where is the first electron coming from? How does the discharge start near to an ice particle?” she asked. Few researchers still favor the rival theory that cosmic rays directly initiate lightning, but cosmic rays could still play a secondary role in creating electrons <a data-event-click='{"element":"ExternalLink","outgoingURL":"https://agupubs.onlinelibrary.wiley.com/doi/10.1029/2018JD029040"}' data-offer-url="https://agupubs.onlinelibrary.wiley.com/doi/10.1029/2018JD029040" href="https://agupubs.onlinelibrary.wiley.com/doi/10.1029/2018JD029040" rel="external nofollow" target="_blank">that trigger the first streamers</a> that connect to ice crystals, said Ebert. Exactly how streamers turn into leaders is also a “matter of great debate,” said Hare.
				</p>

				<p>
					 
				</p>

				<p>
					Dwyer is hopeful that LOFAR will be capable of resolving these millimeter-scale processes. “We’re trying to see those first little sparks that come off [ice crystals] to capture the initiation action right at the very beginning,” he said.
				</p>

				<p>
					 
				</p>

				<p>
					Initiation is just the first of many intricate steps that lightning takes on its way to the ground. “We don’t know how it propagates and grows,” said Hare. “We don’t know how it connects to the ground.” Scientists hope to map the whole sequence with the LOFAR network. “It’s an entirely new capability, and I think it will increase our understanding of lightning in leaps and bounds,” said Julia Tilles, a lightning researcher at Sandia National Laboratories in New Mexico.
				</p>
			</div>
		</div>
	</div>
</div>

<p>
	 
</p>

<p>
	 
</p>

<p>
	<a href="https://www.wired.com/story/detailed-footage-finally-reveals-what-triggers-lightning/" rel="external nofollow">Detailed Footage Finally Reveals What Triggers Lightning</a>
</p>

<p>
	 
</p>

<p>
	(May require free registration to view)
</p>
]]></description><guid isPermaLink="false">3833</guid><pubDate>Sun, 09 Jan 2022 20:11:08 +0000</pubDate></item><item><title>A Giant Telescope Grows in Space</title><link>https://nsaneforums.com/news/general-news/a-giant-telescope-grows-in-space-r3832/</link><description><![CDATA[<p style="text-align:center;">
	<span style="font-size:18px;"><strong>A Giant Telescope Grows in Space</strong></span>
</p>

<p style="text-align:center;">
	 
</p>

<p style="text-align:center;">
	<img alt="08webb-update4-superJumbo.jpg?quality=75" class="ipsImage" data-ratio="75.10" height="479" width="720" src="https://static01.nyt.com/images/2022/01/08/science/08webb-update4/08webb-update4-superJumbo.jpg?quality=75&amp;auto=webp" />
</p>

<p style="text-align:center;">
	<span>An artist’s concept of the fully deployed and unfolded James Webb Space Telescope, which is currently on its way to a spot called L2, where it will orbit the sun. It is now 600,000 miles from Earth.</span><span><span>Credit...</span><span><span>Adriana Manrique Gutierrez/NASA</span></span></span>
</p>

<p>
	 
</p>


	<div style="font-size:16px;line-height:16px;">
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				<p style="font-size:15px;line-height:20px;">
					<span style="font-size:15px;line-height:20px;">By </span><span style="font-size:15px;line-height:20px;"><a href="https://www.nytimes.com/by/dennis-overbye" style="font-size:15px;line-height:20px;" rel="external nofollow">Dennis Overbye</a></span> and <span style="font-size:15px;line-height:20px;"><a href="https://www.nytimes.com/by/joey-roulette" style="font-size:15px;line-height:20px;" rel="external nofollow">Joey Roulette</a></span>
				</p>
			</div>
		</div>
	</div>

	<div style="font-size:16px;line-height:16px;">
		<span style="font-size:13px;line-height:16px;">Jan. 8, 2022</span><span style="font-size:13px;line-height:16px;">Updated <span style="font-size:13px;line-height:16px;">4:14 p.m. ET</span></span>
	</div>



	<div style="font-size:16px;line-height:16px;">
		<div style="font-size:16px;line-height:16px;">
			<p style="font-size:20px;line-height:30px;">
				Astronomers are starting to breathe again.
			</p>

			<p style="font-size:20px;line-height:30px;">
				Two weeks ago, the most powerful space observatory ever built roared into the sky, carrying the hopes and dreams of a generation of astronomers in a tightly wrapped package of mirrors, wires, motors, cables, latches and willowy sheets of thin plastic on a pillar of smoke and fire.
			</p>

			<p style="font-size:20px;line-height:30px;">
				On Saturday, the observatory, the James Webb Space Telescope, completed a final, crucial step around 10:30 a.m. by unfolding the last section of its golden, hexagonal mirrors. Nearly three hours later, engineers sent commands to latch those mirrors into place, a step that amounted to it becoming fully deployed, according to NASA.
			</p>

			<p style="font-size:20px;line-height:30px;">
				It was the most recent of a series of delicate maneuvers with what the space agency called 344 “single points of failure” while speeding far away in space. Now the telescope is almost ready for business, although more tense moments are still in its future.
			</p>
		</div>

		
			 
		
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	<div style="font-size:16px;">
		 
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	<div style="font-size:16px;line-height:16px;">
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			<p style="font-size:20px;line-height:30px;">
				“I’m emotional about it,” Thomas Zurbuchen, NASA’s science chief, said of all the telescope’s mirrors finally clicking into place. “What an amazing milestone — we see that beautiful pattern out there in the sky now almost complete.”
			</p>

			<div style="font-size:16px;line-height:16px;">
				<p style="font-size:20px;line-height:30px;">
					The James Webb Space Telescope, named after a former NASA administrator who oversaw the formative years of the Apollo program, is 25 years and $10 billion in the making. It is three times the size of the Hubble Space Telescope and designed to see further into the past than its celebrated predecessor in order to study the first stars and galaxies to turn on in the dawn of time.
				</p>

				<p style="font-size:20px;line-height:30px;">
					The launch on an Ariane rocket on the morning of Dec. 25 was flawless; so flawless that the engineers said it saved enough maneuvering fuel to extend the mission’s estimated 10-year lifetime, perhaps by as much as an additional 10 years, said Mike Menzel, a mission systems engineer at NASA Goddard. But the telescope must complete a monthlong journey to a spot a million miles up, far beyond the moon’s orbit, called L2, where gravitational fields of the Earth and sun commingle to produce the conditions for a stable orbit around the sun.
				</p>
			</div>

			<p style="font-size:20px;line-height:30px;">
				More at:   <a href="https://www.nytimes.com/2022/01/08/science/james-webb-telescope-nasa-deployment.html" rel="external nofollow">Source</a>
			</p>

			<p style="font-size:20px;line-height:30px;">
				 
			</p>

			<p style="font-size:20px;line-height:30px;">
				Source comes from NYT. You might need a "Paywall Bypass" to access it...
			</p>
		</div>
	</div>

]]></description><guid isPermaLink="false">3832</guid><pubDate>Sat, 08 Jan 2022 22:32:24 +0000</pubDate></item><item><title>Remarkably, NASA has completed deployment of the Webb space telescope</title><link>https://nsaneforums.com/news/general-news/remarkably-nasa-has-completed-deployment-of-the-webb-space-telescope-r3828/</link><description><![CDATA[<header>
	<h2 itemprop="description">
		"This is an amazing milestone."
	</h2>
</header>

<section>
	<div itemprop="articleBody">
		<p>
			For much of the world, Saturday was just another weekend day filled with all of this planet's problems and perils. The Omicron-fueled pandemic raged around the globe. New York emerged from its first snowstorm of the season. Turmoil continued in Kazakhstan and elsewhere
		</p>

		<p>
			 
		</p>

		<p>
			But in space. In space. On Saturday, in space, there was a great triumph.
		</p>

		<p>
			 
		</p>

		<p>
			After a quarter century of effort by tens of thousands of people, more than $10 billion in taxpayer funding, and some 350 deployment mechanisms that had to go just so, the James Webb Space Telescope fully unfurled its wings. The massive spacecraft completed its final deployments and, by God, the process went smoothly.
		</p>

		<p>
			 
		</p>

		<p>
			Thanks to NASA, and space agencies in Europe and Canada, the world has a brilliant new space telescope that will allow humanity to see far further back into the depths of galactic time than ever before, and quite possibly identify the first truly Earth-like worlds around other stars.
		</p>

		<p>
			 
		</p>

		<p>
			I dare say that 99 percent of the world will not know or realize or care to understand the amount of work and engineering and paperwork that went into building, launching, and deploying the James Webb Space Telescope. But those of us who know, we know. And we are in awe.
		</p>

		<p>
			 
		</p>

		<p>
			In something of an understatement after full deployment, NASA's chief of science, Thomas Zurbuchen, said, "This is an amazing milestone."
		</p>

		<p>
			 
		</p>

		<p>
			Serious planning for a successor to the Hubble Space Telescope began in the 1990s, and scientists were keen to see back further, into the early universe. To do this they would need a dark, cold environment far from Earth. This is because to collect light from the most faint, distant objects in the universe requires not just a very large mirror, but also no background interference.
		</p>

		<p>
			 
		</p>

		<p>
			To do this, scientists planned to build a telescope that would make observations in the infrared part of the spectrum, where wavelengths are just a little bit longer than red light. This portion of the spectrum is good both for detecting heat emissions, and such wavelengths are long enough that there's less chance they will be deflected by interstellar dust.
		</p>

		<p>
			 
		</p>

		<p>
			Such a telescope would need to be very cold, however, which is how scientists came to devise a large, tennis-court sized heat shield to block light and heat from the Sun. But because no rocket has a super-large fairing, this heat shield and telescope would necessarily need to be folded like origami to fit within the protective cocoon atop a rocket. Nothing like that had ever been tried before. Building this heat shield, testing it, and ensuring it could be deployed in space required the better part of two decades.
		</p>

		<p>
			 
		</p>

		<p>
			Therefore, while the launch of the Webb telescope on Christmas Day two weeks ago was momentous, it was just the beginning of the end of Webb's journey from concept to science operations. As part of the deployment process, there were 344 actions where a single-point failure could scuttle the telescope. This is a remarkable number of instances without a redundant capability, which is why many of the scientists and engineers I have spoken with in recent years felt that Webb had a pretty good chance of failing once in space.
		</p>

		<p>
			 
		</p>

		<p>
			But now that ultra complex heat shield is working. The temperature on the Sun-facing side of the telescope is 55 degrees Celsius, or a very, very, very hot day in the Sahara desert. And already, the science instruments on the back side of the sunshield have cooled to -199 degrees Celsius, a temperature at which nitrogen is a liquid. They will yet cool further.
		</p>

		<p>
			 
		</p>

		<p>
			Work remains, of course. <a href="https://www.jwst.nasa.gov/content/webbLaunch/whereIsWebb.html?units=metric" rel="external nofollow">Webb still must traverse</a> about 370,000 km to reach an orbit around a stable Lagrange point, L2. Scientists and engineers must check out and align the 18 primary mirror segments. Scientific instruments must be calibrated. But all of this work is somewhat more routine when it comes to science spacecraft. There are risks, to be sure, but these are mostly known risks.
		</p>

		<p>
			 
		</p>

		<p>
			We can therefore be reasonably confident now that Webb will, in fact, begin to make science observations this summer. We should, truly, be in awe.
		</p>
	</div>
</section>

<p>
	 
</p>

<p>
	 
</p>

<p>
	<a href="https://arstechnica.com/science/2022/01/remarkably-nasa-has-completed-deployment-of-the-webb-space-telescope/" rel="external nofollow">Remarkably, NASA has completed deployment of the Webb space telescope</a>
</p>
]]></description><guid isPermaLink="false">3828</guid><pubDate>Sat, 08 Jan 2022 21:40:58 +0000</pubDate></item><item><title>The Physics of the James Webb Space Telescope</title><link>https://nsaneforums.com/news/general-news/the-physics-of-the-james-webb-space-telescope-r3818/</link><description><![CDATA[<div>
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					<strong>Humanity has a new eye in the sky, with infrared sensors that will peer into the farthest reaches of the cosmos. Here’s how it works.</strong>
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								The James Webb Space Telescope, also known as the JWST, <a href="https://www.wired.com/story/the-james-webb-space-telescope-finally-prepares-for-launch/" rel="external nofollow">finally launched</a> on December 25 for its journey 930,000 miles from Earth. This is the next generation that will <a href="https://www.wired.com/story/nasa-tries-to-save-hubble-again/" rel="external nofollow">replace the famous Hubble Space Telescope</a>. Hubble has been <a href="https://www.wired.com/story/space-photos-of-the-week-happy-birthday-hubble-30/" rel="external nofollow">capturing awesome photos for over 30 years</a>, but it's time for something better. The JWST will be tasked with using its infrared sensors to explore some of the most distant and hard-to-see parts of the sky, helping with the search for exoplanets and with exploring the earliest days of the universe. So this seems like a good time to go over the most important scientific concepts that relate to space telescopes.
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								<span style="font-size:18px;"><strong>Why Put a Telescope in Space?</strong></span>
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								You can see all sorts of cool stuff, like nebulae and comets, from Earth with just some binoculars or a consumer telescope. But if you want research-quality images of distant galaxies, you have a problem: air. You might think air is transparent, but that’s only partially correct.
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								Light is an electromagnetic wave, and it can have different wavelengths. People can only see a narrow range of wavelengths, from 380 nanometers (1 nm is 10-9 meter) to about 700. Our brains interpret the longer ones as red and the shorter ones as violet. These wavelengths are able to pass through the atmosphere without much of a decrease in brightness—so we can say the air is transparent to visible light.
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								However, for other wavelengths of light that we can't detect with our eyes, the air is not so transparent. If we consider the infrared region of the electromagnetic spectrum (or wavelengths longer than red), then much of this light can be absorbed by both water vapor and carbon dioxide in the atmosphere. (Yes, this is the same thing that happens with global warming: When visible light hits the Earth’s surface, the temperature increases and it radiates infrared. Carbon dioxide in the air absorbs some of this infrared to further increase the atmosphere’s temperature. This can lead to <a href="https://www.wired.com/story/the-un-climate-report-all-is-not-well-but-all-is-not-lost/" rel="external nofollow">bad</a> <a href="https://www.wired.com/story/did-climate-change-make-that-freak-weather-even-worse/" rel="external nofollow">things</a> <a href="https://www.wired.com/story/2021-was-a-huge-missed-opportunity-on-climate-action/" rel="external nofollow">for humans</a>.)
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								This light absorption is also a particular problem for a ground-based infrared telescope. It would be like trying to look at the skies through clouds—it just wouldn’t work.
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								One solution to this problem is to just put the telescope where there is no air: in space. (Of course, with every solution comes more challenges. In this case, you actually have to put a super-sensitive scientific instrument on a rocket and launch it, which is a bold move.)
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								<span style="font-size:18px;"><strong>Why Does the JWST Look at Infrared Light?</strong></span>
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								The JWST actually looks at two ranges of infrared light: the near infrared and mid-infrared. The near infrared is light with wavelengths very close to visible red light. It's the wavelength that your TV remote uses (if you can find it—it’s probably under the couch cushions).
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								The mid-range infrared is often associated with heat, and that's mostly true. It turns out that everything produces light. Yes, you are sitting there making light. The wavelength of light that an object emits depends on its temperature. The hotter it gets, the shorter the wavelength of light. So, while you can’t see light emitted in the mid-infrared range, sometimes you can feel it.
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								Try this: Turn on the stovetop in your kitchen, and hold your hand over a burner but don’t touch it. As the element warms up, it produces infrared light. You can't see this light, but when it hits your hand, you can feel it as heat.
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								Although you can't see this kind of light, an infrared camera can. Check out this infrared image of me pouring a hot cup of coffee:
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								This is a false-color image. Basically, the camera mapped colors—from yellow to purple—onto different wavelengths of infrared light. The brighter yellow parts (like the pot of coffee) represent hotter things, and the darker purple parts are colder. Of course, reality is more complicated than this (you can also have reflected infrared light), but you get the idea.
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								Great. But why does the JWST look at infrared light? The reason is the Doppler effect.
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								You already know about the Doppler effect. You can hear it when a train or car moves past you at a high speed: The sound changes frequency because the source is first moving toward you, and then later away from you. The vehicle’s sound has a shorter wavelength, and therefore a higher pitch, while coming toward you, and then a longer wavelength and a lower pitch when it is moving away. (Here's an older post <a href="https://www.wired.com/story/physics-doppler-effect-represented-tiny-balls" rel="external nofollow">with more details</a>).)
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								It just so happens that you can also get a Doppler effect with light—but since the speed of light is super fast (3 x 108 m/s), the effect isn't noticeable in many situations. However, because of the expansion of the universe, just about all of the galaxies that we see from Earth are moving away from us. So to us, their light appears to have a longer wavelength. We call this a redshift, meaning the wavelengths are more red because they are longer. For very distant objects, this red shift is so large that the interesting stuff is in the infrared spectrum.
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								There's actually another good reason to use infrared light for the JWST: It's difficult to get an unobstructed view of far-away celestial objects thanks to the gas and dust that are the detritus from old stars. These can scatter visible light more easily than they can infrared wavelengths. Essentially, infrared sensors are able to see through these clouds better than visible light telescopes can.
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								Since the JWST is observing in the infrared spectrum, scientists will need everything to be as dark as possible around the telescope. That means that the telescope itself needs to be extremely cold to avoid emitting its own infrared radiation. This is one reason it has a sunshield. It will block the sunlight from the main instruments so they can stay cold. It will also help blot out excess light so the telescope can <a href="https://www.wired.com/story/to-study-the-next-earth-nasa-may-need-to-throw-some-shade/" rel="external nofollow">pick up the comparatively dim light from exoplanets</a> as they orbit their much brighter host stars. (Otherwise, it would be like trying to see in the dark while someone shines a flashlight in your face.)
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								<span style="font-size:18px;"><strong>How Does the JWST Look Back in Time?</strong></span>
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								Light is a wave that travels really, really fast. In just a second, light could go around the circumference of the Earth more than seven times.
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								When viewing celestial objects, we have to take into account the time it takes for light to travel from the object to our telescope or eyes. For example, light from the nearby Alpha Centauri star system takes 4.37 years to reach the Earth. So if you see it in the sky, you are literally looking 4.37 years into the past.
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								(Actually, everything you see is in the past. You see the moon about 1.3 seconds in the past. When spotted closest to Earth, Mars is three minutes in the past.)
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								The idea is for the JWST to be able to see more than 13 billion years into the past, to the point in the evolution of the universe when the first stars were being formed. That's just awesome, if you think about it.
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								<span style="font-size:18px;"><strong>What Is a Lagrange Point?</strong></span>
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								The Hubble Space Telescope is in <a href="https://www.wired.com/2015/09/whats-special-low-earth-orbit/" rel="external nofollow">low Earth orbit</a>, which is nice because it has been possible for astronauts to service it when needed. But the JWST is going to be much farther away, at the L2 Lagrange point. But what the heck is a Lagrange point?
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								Let's consider Hubble orbiting the Earth. For any object moving in a circle, there needs to be a centripetal force, or a force pulling it towards the circle’s center. If you swing a ball on a string around your head, the force pulling it towards the center is the tension in the string. For Hubble, this centripetal force is the gravitational force due to its interaction with the Earth.
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								As an object moves farther away from Earth, the strength of this gravitational force decreases. So, if the telescope moved into a higher orbit (a larger circular radius), the centripetal force would decrease. In order to stay in a circular orbit, Hubble would have to take longer to orbit. (We would say it has a lower angular velocity.)
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								The JWST orbits the sun instead of the Earth—but the same idea applies. The greater the orbital distance, the more time it takes to complete an orbit. But what if you want the JWST to be both further from the sun and complete a solar orbit in the same amount of time as the Earth? (To make it easier to control, the telescope would also have to remain in the same position relative to the Earth.) In order to get this to happen, you need to use a trick.
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								That trick is a Lagrange point, a location in space where both the Earth and the sun exert a gravitational force in the same direction. An object at this point has two gravitational forces pulling on it to make it move in a circle. This allows it to orbit the sun with a higher angular velocity. It also keeps it at a fixed point relative to our planet.
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								There are five Lagrange points for the Earth-sun system. (If there is an L2 then there should at least be an L1—right?) <a data-event-click='{"element":"ExternalLink","outgoingURL":"https://www.nasa.gov/topics/universe/features/webb-l2.html"}' data-offer-url="https://www.nasa.gov/topics/universe/features/webb-l2.html" href="https://www.nasa.gov/topics/universe/features/webb-l2.html" rel="external nofollow" target="_blank">The L2 Lagrange point</a> is about 1.5 million kilometers from Earth, which is quite a bit farther than the 400 kilometers of low Earth orbit.
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								Here are the four other Lagrange points for the Earth-sun system (not shown to scale):
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								Actually, the JWST won’t sit right at the L2 point. Instead, it will be in a very slow orbit. I know it seems bizarre that an object can orbit where there's nothing—but remember, the telescope won’t actually be orbiting the L2 point; it will be orbiting the sun. It will only look like it's orbiting L2 from our rotating reference point here on the Earth.
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								<span style="font-size:18px;"><strong>Why Should Humans Spend Billions on the JWST?</strong></span>
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								The telescope has cost around $8.8 billion dollars, plus another billion is planned for its operating costs. Some people might say it's just too much money. In fact, you could convince me that there are a significant number of projects for which so many billions would be better spent.
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								But the JWST is still a good idea. It's an investment in basic science. Science, like art or literature or sports, is one of those things that make us human. Part of human nature is our curiosity about the universe around us. With the telescope, perhaps we will find out what the cosmos was like shortly after the Big Bang. We will be able to <a href="https://www.wired.com/story/how-two-nobel-laureates-spotted-the-first-exoplanet/" rel="external nofollow">find more</a> <a href="https://www.wired.com/story/nasa-wants-to-photograph-the-surface-of-an-exoplanet/" rel="external nofollow">planets</a> <a href="https://www.wired.com/story/scientists-find-water-vapor-on-the-most-habitable-exoplanet-yet/" rel="external nofollow">around</a> <a href="https://www.wired.com/story/this-is-how-aliens-might-search-for-human-life/" rel="external nofollow">other stars</a> and even look for <a href="https://www.wired.com/story/can-alien-smog-lead-us-to-extraterrestrial-civilizations/" rel="external nofollow">signatures</a> <a href="https://www.wired.com/story/will-we-recognize-life-on-mars-when-we-see-it/" rel="external nofollow">of life</a>. We’ll learn what the first galaxies were like, and how they formed. But I think the best thing that we can hope for from the James Webb Space Telescope is answers to the questions that haven't even been asked yet.
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	<a href="https://www.wired.com/story/the-physics-of-the-james-webb-space-telescope/" rel="external nofollow">The Physics of the James Webb Space Telescope</a>
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]]></description><guid isPermaLink="false">3818</guid><pubDate>Fri, 07 Jan 2022 20:39:01 +0000</pubDate></item><item><title>Astronomers Discover a Strange Galaxy Without Dark Matter</title><link>https://nsaneforums.com/news/general-news/astronomers-discover-a-strange-galaxy-without-dark-matter-r3817/</link><description><![CDATA[<div>
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					<strong>New, high-resolution observations of a faint, fluffy galaxy suggest that dark matter’s not as ubiquitous as scientists thought.</strong>
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						Astronomers mapped out the stars (shown here in blue) and gas (green) of the strange galaxy known as AGC 114905.Photograph: Javier Román &amp; Pavel Mancera Piña
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								Three years ago, Filippo Fraternali and his colleagues spotted a half dozen mysteriously diffuse galaxies, which looked like sprawling cities of stars and gas. But unlike almost every other galaxy ever seen—including our own Milky Way—they didn’t seem to be enshrouded in huge masses of dark matter, which would normally hold those stellar metropolises together with their gravity. The scientists picked one to zoom in on, a modest-sized galaxy about 250,000 light-years away, and they pointed the 27 radio telescope antennas of the Very Large Array in New Mexico at it.
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								After gathering 40 hours’ worth of data, they mapped out the stars and gas and confirmed what the earlier snapshots had hinted at: “The dark matter content that we infer in this galaxy is much, much smaller than what you would expect,” says Fraternali, an astronomer at Kapteyn Astronomical Institute of the University of Groningen in the Netherlands. If the team or their competitors find other such galaxies, it could pose a challenge for scientists’ <a href="https://www.wired.com/story/the-search-for-dark-matter-is-dramatically-expanding/" rel="external nofollow">view of</a> <a href="https://www.wired.com/story/wheres-the-dark-matter-look-for-suspiciously-warm-planets/" rel="external nofollow">dark</a> <a href="https://www.wired.com/story/the-great-neutrino-mystery-could-point-to-missing-particles/" rel="external nofollow">matter</a>, the dominant perspective in the field for at least 20 years. Fraternali and his team <a data-event-click='{"element":"ExternalLink","outgoingURL":"https://academic.oup.com/mnras/advance-article/doi/10.1093/mnras/stab3491/6461100"}' data-offer-url="https://academic.oup.com/mnras/advance-article/doi/10.1093/mnras/stab3491/6461100" href="https://academic.oup.com/mnras/advance-article/doi/10.1093/mnras/stab3491/6461100" rel="external nofollow" target="_blank">published their findings</a> in December in the Monthly Notices of the Royal Astronomical Society.
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								Based on decades of telescope observations and computer simulations, scientists have come to think of dark matter as the hidden skeleton of the cosmos; its “joints” are massive clumps of invisible particles which host galaxies large and small. But Fraternali isn’t the first to glimpse an exception to that rule. A few years ago, Pieter van Dokkum, an astronomer at Yale, and his colleagues <a href="https://www.wired.com/story/astronomers-have-found-two-galaxies-with-no-dark-matter/" rel="external nofollow">discovered</a> similar galaxies with the <a href="https://www.wired.com/story/nasa-tries-to-save-hubble-again/" rel="external nofollow">Hubble telescope</a> that also seemed to lack dark matter. “These galaxies that we found in 2018, they created a lot of controversy and discussion and follow-up work because they were unexpected and difficult to explain,” van Dokkum says.
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								Those other galaxies lived in a crowded environment, where bigger, neighboring galaxies frequently fly by, possibly pulling away dark matter with them. In contrast, Fraternali’s galaxy is pretty isolated, with no such bothersome neighbors, so its dearth of dark matter can’t be explained that way. “It could be very significant,” van Dokkum says. “How do you get stars and gas in that location together without the help of dark matter?”
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								These strange objects have come to be called “ultra-diffuse galaxies.” They’re extreme outliers: In terms of their mass, they’re minuscule, but they’re spread out over vast distances. Some are as large as the Milky Way, but with only a hundredth as many stars—or even fewer. They’re so close to being transparent that they’re tough to spy in the night sky. “They’re slightly fainter in the center, so they’re difficult to detect. Now, with better telescopes and deeper observations, they have become more well known,” says Mireia Montes, an astronomer at the Space Telescope Science Institute in Baltimore and an expert on such galaxies.
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								Starting in the 1960s, American astronomer Vera Rubin and others first revealed the likely existence of unseen, or “dark,” matter while measuring how fast stars in galaxies whirl around the center, showing that inner stars orbit at different speeds than outer ones. Based on those stars’ rotation, scientists calculated how much mass the galaxy must have to keep them constantly orbiting, rather than being flung into space. For many galaxies, that mass was many times larger than that of all the stars added up. Scientists resolved the problem by inferring the presence of some kind of dark matter, which doesn’t emit or reflect light, and which must be making up the rest of the mass that’s holding the galaxy together.
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								But the measurements by Fraternali and his team show that, for their extremely diffuse galaxy, there’s no need to invoke dark matter. The rotation speeds they measure totally match up with the mass of the stars and gas clouds they observed, without requiring any extra mass that can’t be seen. Montes and her research group aim to study these galaxies, including in their outskirts, in more detail in case there’s missing matter that Fraternali hasn’t detected. But at least for now, this ghostly galaxy remains a conundrum.
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								Fraternali points out that their galaxy, known as AGC 114905, has a big X factor: It’s tilted. Some galaxies are shaped like flying saucers, and if telescopes on Earth can see them edge-on, that makes observing them easy for astronomers. They can see the orbiting stars on one side of the galactic disc moving toward us, and those on the other side orbiting away from us. If they can measure those stars’ speeds, they can estimate the galaxy’s mass—and figure out if some of the total must be composed of dark matter. But Fraternali calculates that AGC 114905 is inclined by a little more than 30 degrees, so astronomers have to correct their mass measurements to account for that tilt. If they’re wrong about that degree of tilt, their measurements actually could leave plenty of room for dark matter.
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								But assuming the team is right, it’s not yet clear exactly what kind of exception their galaxy may be. Is it a really weird cosmic object that nobody understands? Or is it a harbinger of bigger problems for dark matter theories? 
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								So far, it doesn’t fit any of the proposed explanations for the origins of ultra-diffuse galaxies. Some astronomers speculate that such a low-dark-matter galaxy could be the remnant of a pair of bigger galaxies tugging at each other with their gravitational pull during a close flyby, leaving a puffy blob of stars and gas in their wake. But there’s no giant galaxy next door, so that doesn’t explain it, van Dokkum says.
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								Another theory is that it could be the remnant of past stellar explosions. All stars eventually die, and some go out with a bang, going supernova. Over time, supernovas might spread out parts of a galaxy, expelling matter, including gas clouds. But that’s not the case with AGC 114905, Fraternali says, since it’s still filled with lots of gas, which serves as the building material and fuel for new stars. And if the galaxy used to be much more concentrated eons ago, one would expect lots of compact clusters of stars left over today, indicators of a denser past. But the galaxy lacks many clusters like that, van Dokkum says.
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								In fact, AGC 114905 doesn’t seem to fit any model that includes dark matter. For decades, scientists like Laura Sales, an astrophysicist at UC Riverside, have simulated the cosmos on powerful computers, trying to show how dark matter models can reproduce the myriad galaxies astronomers spot with their telescopes. “We quickly looked into our simulations, and we don’t have something like this galaxy,” she says. 
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								Instead, Fraternali’s galaxy and others like it could point to a need for <a href="https://www.wired.com/2017/01/case-dark-matter/" rel="external nofollow">alternatives to dark matter</a>. When scientists infer the presence of hidden matter lurking about, they’re making assumptions about how gravity works. But what if gravity operates a bit differently than they thought? 
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								In their work, Fraternali and his colleagues tested a leading contender among dark matter alternatives, called MOND, for Modified Newtonian Dynamics, which involves tweaking Isaac Newton’s law of gravity. First proposed by Israeli physicist Mordehai Milgrom in the 1980s, MOND hypothesizes that standard gravitational physics, which accurately explains the motions of objects with high gravitational accelerations, like planets in our solar system, might not apply the same way to slowly orbiting stars at the edge of a galaxy’s disc. So the discrepancy between the expected velocities of the stars in galaxies and how fast they appear to be moving may not indicate missing mass, but rather a math error, if the MOND gravitational law is right. But while the MOND model fares well with more normal galaxies, it too couldn’t explain the rotation of Fraternali’s team’s fluffy galaxy. It fared just as poorly as dark matter models do. 
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								It’s too early to tell whether AGC 114905 indicates a problem with theories of dark matter, Sales says. For now, Fraternali and others will continue to examine these enigmatic and previously overlooked galaxies, including with the newly launched <a href="https://www.wired.com/story/the-james-webb-space-telescope-finally-prepares-for-launch/" rel="external nofollow">James Webb Space Telescope</a>, in the hopes of resolving this riddle. “It’s not like we’re probing the edge of the universe, or <a href="https://www.wired.com/story/to-study-the-next-earth-nasa-may-need-to-throw-some-shade/" rel="external nofollow">trying to see a tiny planet next to a star</a>. It’s actually doable with the tools that we have,” van Dokkum says. “To me, that makes it exciting.”
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	<a href="https://www.wired.com/story/astronomers-discover-a-strange-galaxy-without-dark-matter/" rel="external nofollow">Astronomers Discover a Strange Galaxy Without Dark Matter</a>
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	(May require free registration to view)
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]]></description><guid isPermaLink="false">3817</guid><pubDate>Fri, 07 Jan 2022 20:28:30 +0000</pubDate></item></channel></rss>
